Article
Cell Biology
Jia Ma, Jing Huang, Jinli Sun, Yanfeng Zhou, Xiaoyuan Ji, Daoxia Guo, Chang Liu, Jiyu Li, Jiye Zhang, Haiyun Song
Summary: The organic selenium compound SeMC showed high sensitivity in inhibiting A549 lung adenocarcinoma cells, inducing synergistic lethality when combined with chemotherapeutics. SeMC promoted lipid peroxidation and increased ROS generation in cancer cells. The in vivo efficacy of combination therapy was significantly enhanced by hydrogel-mediated drug delivery.
CELL PROLIFERATION
(2021)
Article
Medicine, Research & Experimental
Zhiting Deng, Jieqiong Wang, Yang Xiao, Fei Li, Lill Niu, Xin Liu, Long Meng, Hairong Zheng
Summary: The study showed that ultrasound stimulation can enhance the release of exosomes from astrocytes, which have neuroprotective effects against Aβ toxicity. When combined with ultrasound-induced blood-brain-barrier opening, it enables the clearance of Aβ plaques in the brain.
Article
Biochemistry & Molecular Biology
Zhong-Hao Zhang, Jia-Ying Peng, Yu-Bin Chen, Chao Wang, Chen Chen, Guo-Li Song
Summary: Due to the antioxidant capacity of selenium in vivo, various selenium compounds have potential for improving Alzheimer's disease. This study found that different selenium compounds have different effects and mechanisms in the treatment of Alzheimer's disease. Se-methylselenocysteine preferentially increases the expression and activity of thioredoxin reductase, selenomethionine affects glutathione peroxidase 1 expression, and sodium selenate improves methionine sulfoxide reductase B1 expression.
Article
Multidisciplinary Sciences
Soo Hyun Cho, Sookyoung Woo, Changsoo Kim, Hee Jin Kim, Hyemin Jang, Byeong C. Kim, Si Eun Kim, Seung Joo Kim, Jun Pyo Kim, Young Hee Jung, Samuel Lockhart, Rik Ossenkoppele, Susan Landau, Duk L. Na, Michael Weiner, Seonwoo Kim, Sang Won Seo
Summary: This study aimed to construct a disease course model from preclinical AD to AD dementia, finding that ADAS-cog 13 scores decreased most rapidly in women APOE epsilon 4 carriers and most slowly in men APOE epsilon 4 non-carriers. The results suggest that both sex and APOE epsilon 4 status have an impact on the progression of AD.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Ting Hu, Huafen Li, Guishen Zhao, Yanbin Guo
Summary: The study revealed that the mushroom Hypsizygus marmoreus has a strong ability to absorb and convert selenium, converting inorganic selenium forms into organic selenium forms, with Se-methylselenocysteine being the most beneficial form. This suggests that selenium-enriched Hypsizygus marmoreus is a novel selenium food source for human beings.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Cell Biology
Lucia Scipioni, Francesca Ciaramellano, Veronica Carnicelli, Alessandro Leuti, Anna Rita Lizzi, Noemi De Dominicis, Sergio Oddi, Mauro Maccarrone
Summary: This article reviews the role of microglial cells in chronic inflammation in Alzheimer's disease (AD) and the involvement of endocannabinoids in regulating their activity.
Article
Pharmacology & Pharmacy
Xianwei Yang, Menghan Wang, Ximeng Kang, Fei Mo, Peiru Si, Jia Ma, Peipei Zhang, Shaohua Zheng, Jiyu Li, Yang Wang, Qingqing Li, Jiye Zhang
Summary: Vulvar candidiasis (VVC) is a common and harmful infection in women caused by Candida species. This study focused on the potential of L-Se-methylselenocysteine (L-SeMC) and a mucoadhesive thermogel (NAC-HA thermogel) for the treatment of VVC. The L-SeMC@NAC-HA thermogel showed sustained release and prolonged retention time in vitro, as well as demonstrated good safety and significant anti-VVC effects in vivo. These findings suggest that this thermogel could be a promising therapy for the clinical treatment of VVC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Xiaojing Zhou, Abdullah Md. Sheikh, Ken-ichi Matsumoto, Shingo Mitaki, Abu Zaffar Shibly, Yuchi Zhang, A. Garu, Shozo Yano, Atsushi Nagai
Summary: Through proteomic analysis of urine exosomes in AD model mice, we identified proteins related to lipid metabolism and A beta metabolism in the early stages of AD, providing new insights into the underlying pathological mechanism of early AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Molly Muleya, Scott D. Young, Saul Vazquez Reina, Ivy S. Ligowe, Martin R. Broadley, Edward J. M. Joy, Prosper Chopera, Elizabeth H. Bailey
Summary: The study revealed that fertiliser-derived selenium accounted for the majority of selenium in the edible portions of crops, and both fertiliser-derived selenium and soil-derived selenium were transformed into similar organic species, with selenomethionine being the main form of fertiliser-derived selenium. Despite variations in selenium species among different crops, the bioaccessibility of fertiliser-derived selenium showed almost no difference.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Review
Genetics & Heredity
Ruonan Gao, Suk Ling Ma
Summary: Alzheimer's Disease (AD) is the most prevalent form of dementia characterized by progressive memory loss and cognitive decline. Recent studies suggest that mitochondrial dysfunction may be related to AD pathogenesis, and changes in mtDNA could potentially serve as a biomarker for early diagnosis.
Review
Medicine, Research & Experimental
Gyeong Yun Lee, Ok-Hyeon Kim, Eun Ran Kim, Hyun Jung Lee
Summary: This article focuses on the study of the pathogenesis of neurodegenerative disorders, particularly Alzheimer's disease. The biomechanical forces and substrate rigidity in the brain microenvironment change with age, affecting the function of glial cells and neurons. However, our understanding of the role of these biomechanical cues on glial cells and neurons is limited.
Article
Immunology
Dongmei Gu, Luchun Wang, Nan Zhang, Huali Wang, Xin Yu
Summary: This study found that the levels of naturally occurring antibodies (NAbs) decrease in individuals with Alzheimer's disease (AD), and a specific antibody, NAb-TREM2, has the highest sensitivity as a potential biomarker. Further analysis showed that AD-related pathological processes were enriched in the protein-protein interaction network. The findings suggest that the levels of circulating NAbs may serve as biomarkers for monitoring the progression of AD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Environmental Sciences
Kitti Thiankhaw, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: PM2.5 is recognized worldwide as a cause of public health problems, particularly associated with respiratory and cardiovascular diseases. Exposure to PM2.5 is increasingly linked to neurological disorders, such as dementia and Alzheimer's disease, through mechanisms including neuroinflammation, increased ROS production, and neuronal apoptosis.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cell Biology
Luming Zhuang, Chenglin Li, Fei Peng, Elleen Xue, Wenzhe Li, Xinyue Sun, Ping Chen, Qian Zhou, Lei Xue
Summary: Through studying fly AD models, it was found that inhibiting ESCRT components can improve AD-like symptoms induced by APP, suggesting the important role of ESCRT in AD pathogenesis and providing clues for alternative therapeutic strategies for AD.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Immunology
Barbara J. H. Verhaar, Heleen M. A. Hendriksen, Francisca A. de Leeuw, Astrid S. Doorduijn, Mardou van Leeuwenstijn, Charlotte E. Teunissen, Frederik Barkhof, Philip Scheltens, Robert Kraaij, Cornelia M. van Duijn, Max Nieuwdorp, Majon Muller, Wiesje M. van der Flier
Summary: This study investigated the relationship between gut microbiota composition and AD biomarkers using machine learning models. The results showed that lower abundances of SCFA-producing microbes were associated with higher odds of positive amyloid and p-tau status. The study extends on previous findings by showing associations between gut microbiota composition and specific AD biomarkers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Liming Shen, Aochu Yang, Xinqian Chen, Shifeng Xiao, Xukun Liu, Jing Lin, Yuxi Zhao, Kaoyuan Zhang, Cuihua Li, Junyan Ke, Huajie Zhang, Naseer Ullah Khan
Summary: Alzheimer's disease is the most common age-associated dementia with complex pathological hallmarks, and proteomics analysis revealed vulnerable subcellular components and differential protein expression between AD and WT mice; these findings suggest that early events of AD involve decreased energy metabolism, impaired neurotransmitter synthesis, and changes in cytoskeletal proteins.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Oncology
Naseer Ullah Khan, Jing Lin, Muhammad Rizwan Younas, Xukun Liu, Liming Shen
Summary: Gold nanorods with unique optical properties have attracted interest in biomedical field for their potential in simultaneous light-mediated imaging and photothermal cancer treatment. Seed-mediated growth method is commonly used for synthesizing gold nanorods with specific shape and properties for biomedical applications.
CANCER NANOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jing Lin, Kaoyuan Zhang, Xueshan Cao, Yuxi Zhao, Naseer Ullah Khan, Xukun Liu, Xiaoxiao Tang, Margy Chen, Huajie Zhang, Liming Shen
Summary: The study identified 79 differentially expressed proteins in the cerebral cortex of VPA rat model, mainly enriched at synapses and involved in energy metabolism, thyroid hormone synthesis pathway, and cytoskeleton. The dysregulation of these proteins may contribute to autism-like behavior in rats, as well as being associated with neuropsychiatric disorders. Increased expression of proteins related to energy metabolism suggests ASD may involve mitochondrial dysfunction that requires further investigation.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Bingyu Ren, Yingtong Wu, Liumei Huang, Zhiguo Zhang, Bingsheng Huang, Huajie Zhang, Jinting Ma, Bing Li, Xukun Liu, Guangyao Wu, Jian Zhang, Liming Shen, Qiong Liu, Jiazuan Ni
Summary: Machine learning models combining brain structural MRI data and blood parameters show promising potential in accurately predicting brain age, with better performance in older age groups. The fusion model achieved a more accurate prediction of brain age by incorporating multiple indicators, showing significant improvements in evaluating brain health based on MRI and blood parameters.
HUMAN BRAIN MAPPING
(2022)
Article
Endocrinology & Metabolism
Huajie Zhang, Yuxi Zhao, Danqing Zhao, Xinqian Chen, Naseer Ullah Khan, Xukun Liu, Qihong Zheng, Yi Liang, Yuhua Zhu, Javed Iqbal, Jing Lin, Liming Shen
Summary: The study aimed to identify plasma metabolites that can be used as potential biomarkers for GDM, and to clarify GDM-related mechanisms. Differential metabolites in the plasma of GDM pregnant women at 12-16 weeks and 24-28 weeks of pregnancy were identified, some of which may serve as potential biomarkers for GDM prediction and diagnosis. Abnormal amino acid metabolism and lipid metabolism in patients with GDM may be related to GDM pathogenesis.
Article
Endocrinology & Metabolism
Qihong Zheng, Liming Shen, Danqing Zhao, Huajie Zhang, Yi Liang, Yuhua Zhu, Naseer Ullah Khan, Xukun Liu, Jun Zhang, Jing Lin, Xiaoxiao Tang
Summary: The study investigated changes in plasma bile acid (BAs) metabolic profile in pregnant women with intrahepatic cholestasis of pregnancy (ICP) to find biomarkers for diagnosis and grading, and explore disease mechanism. Significant differences in plasma BA profiles were found between ICP patients and controls, with potential diagnostic and grading markers identified. A characteristic of ICP patients was an increase in conjugated BAs.
Correction
Chemistry, Multidisciplinary
Naseer Ullah Khan, Zahir Muhammad, Xukun Liu, Jing Lin, Qihong Zheng, Huajie Zhang, Samiullah Malik, Hua He, Liming Shen
Article
Neurosciences
Liming Shen, Huajie Zhang, Jing Lin, Yan Gao, Margy Chen, Naseer Ullah Khan, Xiaoxiao Tang, Qi Hong, Chengyun Feng, Yuxi Zhao, Xueshan Cao
Summary: This study conducted genetic testing and biomarker analysis in children with ASD, finding that the differential expressions of proteins and metabolites in plasma and PBMCs could effectively distinguish autistic children from healthy controls. Mechanistic analysis suggested that glycerophospholipid metabolism and N-glycan biosynthesis might play critical roles in the pathogenesis of ASD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jun Zhang, Ting Hu, Yi Wang, Xinglai Zhang, Huajie Zhang, Jing Lin, Xiaoxiao Tang, Xukun Liu, Margy Chen, Naseer Ullah Khan, Liming Shen, Peng Luo
Summary: Arsenic is an important toxic element in the environment, and its effects on the brain are still limitedly studied. This study used proteomics to reveal the mechanism of arsenic neurotoxicity in rats and the protective effect of dictyophora polysaccharide.
Review
Psychiatry
Xukun Liu, Jing Lin, Huajie Zhang, Naseer Ullah Khan, Jun Zhang, Xiaoxiao Tang, Xueshan Cao, Liming Shen
Summary: Autism spectrum disorder is a neurodevelopmental disorder with increasing diagnoses worldwide. Early diagnosis and intervention can improve outcomes. However, there are no clinical biomarkers for ASD. Recent studies have found a link between ASD and oxidative stress, and identified potential biomarkers to detect oxidative stress.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Liming Shen, Xiaoxiao Tang, Huajie Zhang, Hongbin Zhuang, Jing Lin, Yuxi Zhao, Xukun Liu
Summary: This study analyzed the eye tissues of 2- and 6-month-old triple transgenic AD (3 x Tg-AD) male mice and identified differential metabolites associated with various metabolic pathways. The results showed that the eye tissues of 3 x Tg-AD mice underwent changes in the early stages of the disease, and these changes were more pronounced at 6 months of age. The joint analysis with previous hippocampal study revealed similar differential metabolites and mechanisms, but with tissue specificity.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemical Research Methods
Zhiyuan Liang, Hongbin Zhuang, Xueshan Cao, Guanwei Ma, Liming Shen
Summary: Alzheimer's disease is a neurodegenerative disease characterized by cognitive impairment and decreased judgment function. There is currently no specific and effective therapeutic agent due to incomplete understanding of its molecular mechanisms. Proteomics studies have made advances in understanding the mechanism, diagnostic markers, and drug targets of Alzheimer's disease. These studies provide insights into the pathology of Alzheimer's disease and offer potential new biomarkers and drug targets.
PROTEOMICS CLINICAL APPLICATIONS
(2023)
