Assemblages: Functional units formed by cellular phase separation

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1

(2015) Julie S. Barber-Rotenberg et al.   Oncotarget

Pharmacokinetic modeling optimizes inhibition of the ‘undruggable’ EWS-FLI1 transcription factor in Ewing Sarcoma

(2015) Sung-Hyeok Hong et al.   Oncotarget

In Vitro Reconstitution of a Cellular Phase-Transition Process that Involves the mRNA Decapping Machinery

(2014) Simon A. Fromm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Single-molecule spectroscopy reveals polymer effects of disordered proteins in crowded environments

(2014) Andrea Soranno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleolar dysfunction in Huntington's disease

(2013) Junghee Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protein disorder, prion propensities, and self-organizing macromolecular collectives

(2013) Liliana Malinovska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Pleomorphic Ensembles: Formation of Large Clusters Composed of Weakly Interacting Multivalent Molecules

(2013) Cibele V. Falkenberg et al.   BIOPHYSICAL JOURNAL

Conserved Spatial Organization of FG Domains in the Nuclear Pore Complex

(2013) Claire E. Atkinson et al.   BIOPHYSICAL JOURNAL

Uncovering Nuclear Pore Complexity with Innovation

(2013) Rebecca L. Adams et al.   CELL

Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains

(2013) Ilmin Kwon et al.   CELL

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

Recent discoveries and applications involving small-molecule microarrays

(2013) Jiyoung A Hong et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Edgotype: a fundamental link between genotype and phenotype

(2013) Nidhi Sahni et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Multicellular aggregates: a model system for tissue rheology

(2013) Tomita Vasilica Stirbat et al.   EUROPEAN PHYSICAL JOURNAL E

Single-molecule imaging in vivo: the dancing building blocks of the cell

(2013) Miguel Coelho et al.   Integrative Biology

Phase transitions and size scaling of membrane-less organelles

(2013) Clifford P. Brangwynne   JOURNAL OF CELL BIOLOGY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Entry into the nuclear pore complex is controlled by a cytoplasmic exclusion zone containing dynamic GLFG-repeat nucleoporin domains

(2013) J. Fiserova et al.   JOURNAL OF CELL SCIENCE

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells

(2013) Marina Feric et al.   NATURE CELL BIOLOGY

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells

(2013) J Christof M Gebhardt et al.   NATURE METHODS

p53 Aggregates Penetrate Cells and Induce the Co-Aggregation of Intracellular p53

(2013) Karolyn J. Forget et al.   PLoS One

Protein Interactions in Xenopus Germ Plasm RNP Particles

(2013) Sarbjit Nijjar et al.   PLoS One

Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy

(2013) Z. W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation

(2013) S. L. Crick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-to-cell propagation of infectious cytosolic protein aggregates

(2013) J. P. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin

(2013) Nicholas Stephane Caron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

(2013) R. K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Stress granules and cell signaling: more than just a passing phase?

(2013) Nancy Kedersha et al.   TRENDS IN BIOCHEMICAL SCIENCES

Neurofilament sidearms modulate parallel and crossed-filament orientations inducing nematic to isotropic and re-entrant birefringent hydrogels

(2013) Joanna Deek et al.   Nature Communications

Myelin Membrane Assembly Is Driven by a Phase Transition of Myelin Basic Proteins Into a Cohesive Protein Meshwork

(2013) Shweta Aggarwal et al.   PLOS BIOLOGY

Mechanisms of small-molecule binding to intrinsically disordered proteins: Figure 1

(2012) Rémi Cuchillo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

(2012) Oliver D. King et al.   BRAIN RESEARCH

The Permeability of Reconstituted Nuclear Pores Provides Direct Evidence for the Selective Phase Model

(2012) Bastian B. Hülsmann et al.   CELL

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Getting RNA and Protein in Phase

(2012) Stephanie C. Weber et al.   CELL

Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies

(2012) Tina W. Han et al.   CELL

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis

(2012) Julien Couthouis et al.   HUMAN MOLECULAR GENETICS

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Next generation organelles: Structure and role of germ granules in the germline

(2012) Ming Gao et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Dynamic Proteomics of Human Protein Level and Localization across the Cell Cycle

(2012) Shlomit Farkash-Amar et al.   PLoS One

Cellular Strategies for Regulating Functional and Nonfunctional Protein Aggregation

(2012) Jörg Gsponer et al.   Cell Reports

Unbiased binding assays for discovering small-molecule probes and drugs

(2011) Melissa M. Kemp et al.   BIOORGANIC & MEDICINAL CHEMISTRY

P granules extend the nuclear pore complex environment in theC. elegansgerm line

(2011) Dustin L. Updike et al.   JOURNAL OF CELL BIOLOGY

The Ewing Sarcoma Protein Regulates DNA Damage-Induced Alternative Splicing

(2011) Maria Paola Paronetto et al.   MOLECULAR CELL

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

RNA-binding proteins with prion-like domains in ALS and FTLD-U

(2011) Aaron D. Gitler et al.   Prion

RNA Granules in Germ Cells

(2011) E. Voronina et al.   Cold Spring Harbor Perspectives in Biology

Essential Role of Coiled Coils for Aggregation and Activity of Q/N-Rich Prions and PolyQ Proteins

(2010) Ferdinando Fiumara et al.   CELL

Breaking the Diffraction Barrier: Super-Resolution Imaging of Cells

(2010) Bo Huang et al.   CELL

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

Drugs for ‘protein clouds’: targeting intrinsically disordered transcription factors

(2010) A Keith Dunker et al.   CURRENT OPINION IN PHARMACOLOGY

A Bimodal Distribution of Two Distinct Categories of Intrinsically Disordered Structures with Separate Functions in FG Nucleoporins

(2010) Justin Yamada et al.   MOLECULAR & CELLULAR PROTEOMICS

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-like interactions within nucleoporin FG hydrogels

(2010) C. Ader et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge interactions can dominate the dimensions of intrinsically disordered proteins

(2010) S. Muller-Spath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase transitions of folded proteins

(2010) Peter G. Vekilov   Soft Matter

Protein disorder in the human diseasome: unfoldomics of human genetic diseases

(2009) Uros Midic et al.   BMC GENOMICS

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

(2009) Tanya Vavouri et al.   CELL

Bucky Ball Organizes Germ Plasm Assembly in Zebrafish

(2009) Franck Bontems et al.   CURRENT BIOLOGY

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hydrophobicity as a possible reason for gelation of FG-rich nucleoporins

(2009) Philipp M. Diesinger et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Discovery of Novel Myc−Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model

(2009) Gabriela Mustata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of Ewing Sarcoma (EWS)-Binding Proteins: Interaction with hnRNP M, U, and RNA-Helicases p68/72 within Protein−RNA Complexes

(2009) Steffen Pahlich et al.   JOURNAL OF PROTEOME RESEARCH

Edgetic perturbation models of human inherited disorders

(2009) Quan Zhong et al.   Molecular Systems Biology

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

(2009) Hayriye V Erkizan et al.   NATURE MEDICINE

Dynamic Proteomics: a database for dynamics and localizations of endogenous fluorescently-tagged proteins in living human cells

(2009) Milana Frenkel-Morgenstern et al.   NUCLEIC ACIDS RESEARCH

Modularity of intrinsic disorder in the human proteome

(2009) Melissa M. Pentony et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

(2008) Ariele Viacava Follis et al.   CHEMISTRY & BIOLOGY

Bucky ball functions in Balbiani body assembly and animal–vegetal polarity in the oocyte and follicle cell layer in zebrafish

(2008) Florence L. Marlow et al.   DEVELOPMENTAL BIOLOGY

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor

(2008) T. Mittag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiogenic small molecules that enhance myocardial repair by stem cells

(2008) H. Sadek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

(2008) J. Gsponer et al.   SCIENCE

A polymer physics perspective on driving forces and mechanisms for protein aggregation

(2007) Rohit V. Pappu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES