A septin GTPase scaffold of dynein–dynactin motors triggers retrograde lysosome transport

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

Dynactin p150 promotes processive motility of DDB complexes by minimizing diffusional behavior of dynein

(2020) Qingzhou Feng et al.   MOLECULAR BIOLOGY OF THE CELL

A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface

(2020) Danielle Karoline Silva do Vale Castro et al.   IUCrJ

Synergistic role of nucleotides and lipids for the self-assembly of Shs1 septin oligomers

(2020) Cyntia Taveneau et al.   BIOCHEMICAL JOURNAL

Septin 7 is a centrosomal protein that ensures S phase entry and microtubule nucleation by maintaining the abundance of p150 glued

(2020) Ting‐Yu Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

Quantifying Protein Copy Number in Super-Resolution Using an Imaging-Invariant Calibration

(2019) Francesca Cella Zanacchi et al.   BIOPHYSICAL JOURNAL

A Septin Double Ring Controls the Spatiotemporal Organization of the ESCRT Machinery in Cytokinetic Abscission

(2019) Eva P. Karasmanis et al.   CURRENT BIOLOGY

Phosphorylated Rho–GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras–GTP to regulate cell migration

(2019) Hiroshi Senoo et al.   NATURE CELL BIOLOGY

Motor–cargo adaptors at the organelle–cytoskeleton interface

(2019) Jessica A Cross et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy in intracellular bacterial infection

(2019) Wei Hu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Septin 2/6/7 complexes tune microtubule plus-end growth and EB1 binding in a concentration- and filament-dependent manner

(2019) Konstantinos Nakos et al.   MOLECULAR BIOLOGY OF THE CELL

Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity

(2019) Marzia Savini et al.   TRENDS IN CELL BIOLOGY

Plasma membrane repair

(2018) Norma W. Andrews et al.   CURRENT BIOLOGY

Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin

(2018) Eva P. Karasmanis et al.   DEVELOPMENTAL CELL

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Motor Proteins

(2018) H. Lee Sweeney et al.   Cold Spring Harbor Perspectives in Biology

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

(2018) In-Gyun Lee et al.   Nature Communications

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Vesicle trafficking pathways that direct cell migration in 3D and in vivo

(2018) Beverley J. Wilson et al.   TRAFFIC

Septins Recognize and Entrap Dividing Bacterial Cells for Delivery to Lysosomes

(2018) Sina Krokowski et al.   Cell Host & Microbe

Detyrosinated microtubules spatially constrain lysosomes facilitating lysosome–autophagosome fusion

(2018) Nitin Mohan et al.   JOURNAL OF CELL BIOLOGY

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

A Rise in ATP, ROS, and Mitochondrial Content upon Glucose Withdrawal Correlates with a Dysregulated Mitochondria Turnover Mediated by the Activation of the Protein Deacetylase SIRT1

(2018) Seon Song et al.   Cells

Lysosomal Ion Channels as Decoders of Cellular Signals

(2018) Ping Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

(2017) José B. Gama et al.   JOURNAL OF CELL BIOLOGY

Disease-associated mutations in human BICD2 hyperactivate motility of dynein–dynactin

(2017) Walter Huynh et al.   JOURNAL OF CELL BIOLOGY

Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization

(2017) Elena Tortosa et al.   NEURON

BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon

(2017) Ginny G. Farías et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

(2017) Rose Willett et al.   Nature Communications

The step-wise pathway of septin hetero-octamer assembly in budding yeast

(2017) Andrew Weems et al.   eLife

The human cytoplasmic dynein interactome reveals novel activators of motility

(2017) William B Redwine et al.   eLife

Septin 9_i2 is downregulated in tumors, impairs cancer cell migration and alters subnuclear actin filaments

(2017) P. Verdier-Pinard et al.   Scientific Reports

Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion

(2016) Antonio Castro-Castro et al.   Annual Review of Cell and Developmental Biology

Review: Structure and mechanism of the dynein motor ATPase

(2016) Helgo Schmidt et al.   BIOPOLYMERS

Dynein Clusters into Lipid Microdomains on Phagosomes to Drive Rapid Transport toward Lysosomes

(2016) Ashim Rai et al.   CELL

Mitochondria mediate septin cage assembly to promote autophagy ofShigella

(2016) Andrea Sirianni et al.   EMBO REPORTS

Folliculin directs the formation of a Rab34–RILP complex to control the nutrient‐dependent dynamic distribution of lysosomes

(2016) Georgina P Starling et al.   EMBO REPORTS

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion

(2016) Lee Dolat et al.   JOURNAL OF CELL BIOLOGY

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport

(2016) Xiaobo Bai et al.   MOLECULAR BIOLOGY OF THE CELL

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV

(2016) Abdellah Akil et al.   Nature Communications

BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks

(2016) Carlos M. Guardia et al.   Cell Reports

Multifunctional Microtubule-Associated Proteins in Plants

(2016) Jana Krtková et al.   Frontiers in Plant Science

Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response

(2016) Randy J. Giedt et al.   Scientific Reports

Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting

(2015) J. Di Giovanni et al.   EMBO JOURNAL

Septin Form and Function at the Cell Cortex

(2015) Andrew A. Bridges et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Septins promote stress fiber–mediated maturation of focal adhesions and renal epithelial motility

(2014) Lee Dolat et al.   JOURNAL OF CELL BIOLOGY

Septin6 and Septin7 GTP Binding Proteins Regulate AP-3- and ESCRT-Dependent Multivesicular Body Biogenesis

(2014) Sofia Traikov et al.   PLoS One

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Dynactin functions as both a dynamic tether and brake during dynein-driven motility

(2014) Swathi Ayloo et al.   Nature Communications

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

(2014) Courtney M Schroeder et al.   eLife

Human septin isoforms and the GDP-GTP cycle

(2013) Eldar Zent et al.   BIOLOGICAL CHEMISTRY

Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules

(2013) Xiaobo Bai et al.   JOURNAL OF CELL BIOLOGY

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1

(2013) Lymarie Maldonado-Báez et al.   JOURNAL OF CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosomal Membrane Proteins and Their Central Role in Physiology

(2013) Michael Schwake et al.   TRAFFIC

Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

(2013) Marvin E Tanenbaum et al.   eLife

Dynein Tethers and Stabilizes Dynamic Microtubule Plus Ends

(2012) Adam G. Hendricks et al.   CURRENT BIOLOGY

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

(2012) Nicholas A Graham et al.   Molecular Systems Biology

Septins: the fourth component of the cytoskeleton

(2012) Serge Mostowy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and biochemical properties of Sept7, a unique septin required for filament formation

(2011) Eldar Zent et al.   BIOLOGICAL CHEMISTRY

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Septin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epithelia

(2011) Jonathan R. Bowen et al.   JOURNAL OF CELL BIOLOGY

Subunit-dependent modulation of septin assembly: Budding yeast septin Shs1 promotes ring and gauze formation

(2011) Galo Garcia et al.   JOURNAL OF CELL BIOLOGY

SEPT9 occupies the terminal positions in septin octamers and mediates polymerization-dependent functions in abscission

(2011) Moshe S. Kim et al.   JOURNAL OF CELL BIOLOGY

Deciphering the rules governing assembly order of mammalian septin complexes

(2011) Mikael E. Sellin et al.   MOLECULAR BIOLOGY OF THE CELL

Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay

(2010) Lukas C. Kapitein et al.   BIOPHYSICAL JOURNAL

Entrapment of Intracytosolic Bacteria by Septin Cage-like Structures

(2010) Serge Mostowy et al.   Cell Host & Microbe

Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission

(2010) Mathew P. Estey et al.   JOURNAL OF CELL BIOLOGY

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

(2010) Serhiy Pankiv et al.   JOURNAL OF CELL BIOLOGY

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Septins and the Lateral Compartmentalization of Eukaryotic Membranes

(2009) Fabrice Caudron et al.   DEVELOPMENTAL CELL

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GTP-induced conformational changes in septins and implications for function

(2009) M. Sirajuddin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulation of SEPT9_v1 stabilizes c-Jun-N-Terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells

(2008) Maria E. Gonzalez et al.   CELLULAR SIGNALLING