Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high‐fat diet fed mice

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD

(2019) Daniel Garcia et al.   Cell Reports

Tetrahydrocurcumin ameliorates free fatty acid-induced hepatic steatosis and improves insulin resistance in HepG2 cells

(2018) Jin-Wun Chen et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Metformin improves obesity-associated inflammation by altering macrophages polarization

(2018) Yuanyuan Jing et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MCU-knockdown attenuates high glucose-induced inflammation through regulating MAPKs/NF-κB pathways and ROS production in HepG2 cells

(2018) Ghodratollah Panahi et al.   PLoS One

Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis

(2018) Brian N. Finck   DIABETES

A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease

(2017) Zhonge Chen et al.   Lipids in Health and Disease

Non-alcoholic fatty liver disease: A sign of systemic disease

(2017) Isabella Reccia et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome

(2017) Jesús Santana-Gálvez et al.   MOLECULES

Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments

(2017) Hironori Kitade et al.   Nutrients

Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications

(2016) Reza Meshkani et al.   CLINICA CHIMICA ACTA

Current efforts and trends in the treatment of NASH

(2015) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)

(2014) Jia Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chlorogenic Acid Improves High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice

(2014) Yongjie Ma et al.   PHARMACEUTICAL RESEARCH

Metformin Ameliorates Hepatic Steatosis and Inflammation without Altering Adipose Phenotype in Diet-Induced Obesity

(2014) Shih-Lung Woo et al.   PLoS One

Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation

(2013) Khang Wei Ong et al.   BIOCHEMICAL PHARMACOLOGY

Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance

(2013) Mohamed Asrih et al.   JOURNAL OF ENDOCRINOLOGY

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Mechanisms Involved in the Protective Effects of Metformin Against Nonalcoholic Fatty Liver Disease

(2012) V. J. Barbero-Becerra et al.   CURRENT MEDICINAL CHEMISTRY

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

(2012) Rai Ajit K. Srivastava et al.   JOURNAL OF LIPID RESEARCH

Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis

(2012) Yuki Kita et al.   PLoS One

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Metformin Reduces Body Weight Gain and Improves Glucose Intolerance in High-Fat Diet-Fed C57BL/6J Mice

(2010) Yukari Matsui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice

(2010) Ae-Sim Cho et al.   FOOD AND CHEMICAL TOXICOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice

(2010) Yuexin Xu et al.   INFLAMMATION RESEARCH

Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

(2010) Zhenggang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulating Effects of Chlorogenic Acid on Lipids and Glucose Metabolism and Expression of Hepatic Peroxisome Proliferator-activated Receptor-α in Golden Hamsters Fed on High Fat Diet

(2009) Shu-Yuan LI et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade

(2007) Hsiang-Ming Wang et al.   BIOCHEMICAL PHARMACOLOGY