Article
Endocrinology & Metabolism
Charlotte J. Green, Thomas Marjot, John Walsby-Tickle, Catriona Charlton, Thomas Cornfield, Felix Westcott, Katherine E. Pinnick, Ahmad Moolla, Jonathan M. Hazlehurst, James McCullagh, Jeremy W. Tomlinson, Leanne Hodson
Summary: Metformin effectively reduces body weight and improves insulin sensitivity in the treatment of type 2 diabetes, but does not significantly reduce intrahepatic triglyceride content or increase fatty acid oxidation. The treatment does lead to changes in VLDL-triglyceride concentrations and the contribution of de novo lipogenesis-derived fatty acids to VLDL-TG.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Cell Biology
Robert H. Whitson, Shu-Lian Li, Guoxiang Zhang, Garrett P. Larson, Keiichi Itakura
Summary: The research found that Arid5b plays a crucial role in resisting diet-induced obesity, with its absence making mice sensitive to lipid accumulation in specific adipose tissues and reducing inflammatory signaling. This demonstrates the importance of Arid5b in regulating lipid metabolism and accumulation.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Lu Xu, Zhe Huang, Tak-ho Lo, Jimmy Tsz Hang Lee, Ranyao Yang, Xingqun Yan, Dewei Ye, Aimin Xu, Chi-Ming Wong
Summary: The activation of the PRMT1/HNF-4α/PGC-1α signaling pathway may serve as a potential therapeutic strategy for combating non-alcoholic fatty liver disease in obese individuals.
Article
Medicine, Research & Experimental
Lingyan Ma, Yinhua Ni, Luting Hu, Yufeng Zhao, Liujie Zheng, Song Yang, Liyang Ni, Zhengwei Fu
Summary: Spermidine administration can reduce fat mass and plasma lipid profile in HFD-induced obese mice, improve hepatic steatosis, reduce adipose tissue inflammation, and enhance gut barrier function. Additionally, spermidine treatment also enhances thermogenic gene expression in brown adipose tissue.
Article
Nutrition & Dietetics
Shigeru Murakami, Chihiro Hirazawa, Takuma Ohya, Rina Yoshikawa, Toshiki Mizutani, Ning Ma, Mitsuru Moriyama, Takashi Ito, Chiaki Matsuzaki
Summary: The study demonstrated that Sargassum horneri can effectively suppress obesity, diabetes, and other metabolic disorders induced by a high-fat diet, as well as improve insulin resistance. The inhibitory effect of Sargassum horneri on intestinal fat absorption may be one of the key mechanisms for its beneficial effects.
Article
Endocrinology & Metabolism
Bing Liu, Yi Zhong, Dandan Huang, Liuye Yang, Pengchao Wang, Liu Yang, Fengxiao Zhang, Xiaoguang Li, Minglu Liang, Kai Huang, Meng Du
Summary: This study identifies a long non-coding RNA NRON as an important regulator of glucose/lipid metabolism and whole-body energy expenditure. Depletion of Nron in obese mice leads to metabolic benefits, including reduced body weight and fat mass, improved insulin sensitivity and serum lipid parameters, attenuated hepatic steatosis, and enhanced adipose function. The mechanism involves the activation of specific signaling pathways and metabolic networks. Inhibition of Nron may have potential as a therapeutic approach for obesity.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Endocrinology & Metabolism
Tao Tao, Margaret M. Kobelski, Vaibhav Saini, Marie B. Demay
Summary: Risk factors for nonalcoholic hepatic steatosis include obesity and vitamin D deficiency. However, in the absence of obesity or a high-fat diet, the adipocyte vitamin D receptor does not appear to be necessary for the prevention of hepatic inflammation or fibrosis.
Article
Biochemistry & Molecular Biology
Linghuan Li, Guangyao Zhu, Gaohang Fu, Weiwei Zha, Hanbing Li
Summary: This study found that 4-methylesculetin (4-ME) has an improving effect on the adipose microenvironment and hepatic steatosis in mice induced by a high-fat diet. It may be a potential lead compound candidate for preventing obesity and MAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Laxmi Sen Thakuri, Chul Min Park, Hyeon-A Kim, Hyung Jung Kim, Jin Woo Park, Jong Cheol Park, Dong Young Rhyu
Summary: Red seaweed has a long history in traditional Asian medicine and has been used to address various conditions. This study investigated the effects of a specific red seaweed extract on liver injury and lipid and glucose dysregulation, finding promising results.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Endocrinology & Metabolism
Feiyu Cai, Aihemaitijiang Yusufu, Kai Liu, Wenjiao Chen, Ruomei Zhao, Yanshi Liu, Yi Liu
Summary: The study evaluated the difference in bone regeneration between rats under high-fat diets (HFD) and low-fat diets (LFD) by monitoring the process of bone regeneration in distraction osteogenesis (DO) model animals. The results showed that HFD resulted in elevated blood lipids, increased adipose differentiation at the bone marrow level, and delayed bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Nathan L. Price, Xinbo Zhang, Pablo Fernandez-Tussy, Abhishek K. Singh, Sean A. Burnap, Noemi Rotllan, Leigh Goedeke, Jonathan Sun, Alberto Canfran-Duque, Binod Aryal, Manuel Mayr, Yajaira Suarez, Carlos Fernandez-Hernando
Summary: miR-33 is an intronic microRNA that regulates lipid metabolism by targeting ABCA1 to promote cholesterol efflux and improve HDL biogenesis. Liver-specific deficiency of miR-33 enhances glucose homeostasis, reduces fibrosis and inflammation, and increases circulating HDL-C levels. However, these changes are not sufficient to reduce atherosclerotic plaque size under hyperlipidemic conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Stephania Guzman, Magdalena Dragan, Hyokjoon Kwon, Vanessa de Oliveira, Shivani Rao, Vrushank Bhatt, Katarzyna M. Kalemba, Ankit Shah, Vinod K. Rustgi, He Wang, Paul R. Bech, Ali Abbara, Chioma Izzi-Engbeaya, Pinelopi Manousou, Jessie Y. Guo, Grace L. Guo, Sally Radovick, Waljit S. Dhillo, Fredric E. Wondisford, Andy Babwah, Moshmi Bhattacharya
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease associated with obesity, diabetes, and metabolic syndrome. Activation of the kisspeptin 1 receptor (KISS1R) signaling pathway has therapeutic effects in treating NAFLD.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Fernanda Torres Quitete, Giulia Medeiros Almeida Santos, Leilson de Oliveira Ribeiro, Cristiane Aguiar da Costa, Suely Pereira Freitas, Virginia Martins da Matta, Julio Beltrame Daleprane
Summary: Regular consumption of a phenolic-rich smoothie can improve liver antioxidant status, prevent metabolic disorders, and ameliorate non-alcoholic fatty liver disease caused by high-fat diet consumption.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Nutrition & Dietetics
Jianyu Qu, Mengke Ye, Chi Wen, Xianyu Cheng, Lirui Zou, Mengyao Li, Xiangyan Liu, Zhonghua Liu, Lixin Wen, Ji Wang
Summary: By adding green tea, Ilex latifolia Thunb (kuding tea), and Momordica grosvenori (Luo Han Guo) to a new compound dark tea (CDT), the taste and health effects of this beverage can be improved. Under a high-fat diet, low- and high-concentrations of CDT can reduce body weight and body fat by attenuating body weight gain and fat accumulation, improving glucose tolerance, alleviating metabolic endotoxemia, and regulating the mRNA expression levels of lipid metabolism-related genes. Furthermore, low concentrations of CDT can decrease the abundance of Desulfovibrio, which is positively associated with obesity, and increase the abundance of Ruminococcus, which are negatively associated with obesity.
FRONTIERS IN NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Xinbo Zhou, Junjie Zhang, Yutong Sun, Jian Shen, Bo Sun, Qingquan Ma
Summary: This study found that glutamine (Gln) has a positive effect on liver steatosis and promotes hepatic homeostasis by improving glucose metabolism and regulating signaling pathways. Obese mice fed with Gln had higher levels of colonic short-chain fatty acids (SCFAs) and lower levels of inflammation factor proteins, and a decrease in the abundance of Firmicutes bacteria was observed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Y. Xie, Q. Tang, S. Yu, W. Zheng, G. Chen, X. Huang, L. Chen
Summary: BMAL1 in PDLCs plays a crucial role in sensing and transmitting biomechanical signals during orthodontic tooth movement. Upregulation of BMAL1 expression by orthodontic force can enhance secretion of CCL2 and RANKL, ultimately promoting osteoclast recruitment. Inhibition of ERK/AP1/BMAL1 signaling can effectively reduce osteoclastic activity and slow down orthodontic tooth movement.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Surgery
Junyi Zhu, Zirong Tang, Jiangang Ren, Jinhuan Geng, Fengyuan Guo, Zhi Xu, Jun Jia, Lili Chen, Yulin Jia
Summary: This study revealed for the first time the downregulation of miR-21 in venous malformations (VMs), which may contribute to decreased collagen expression through the TGF-beta/Smad3/miR-21 signaling feedback loop. These findings provide new insights into the pathogenesis of VMs and may facilitate the development of new therapeutic approaches.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Jingwei Yan, Anqi Li, Xianglin Chen, Kaixiang Cao, Mingchuan Song, Shuai Guo, Zou Li, Shuqi Huang, Ziling Li, Danghan Xu, Yong Wang, Xiaoyan Dai, Du Feng, Yuqing Huo, Jun He, Yiming Xu
Summary: The study found that MDSCs appear in the blood of stroke patients in the early stage, and similar results were observed in a rat brain model induced by temporary middle cerebral artery occlusion. The research showed that pharmaceutical depletion of MDSCs worsens ischemic brain injury, while adoptive transfer of MDSCs can rescue the damage.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Jiwei Sun, Tiantian Chen, Baoying Zhao, Wenjie Fan, Yufeng Shen, Haojie Wei, Man Zhang, Wenhao Zheng, Jinfeng Peng, Jinyu Wang, Yifan Wang, Lihong Fan, Yingying Chu, Lili Chen, Cheng Yang
Summary: Oral wounds under diabetic conditions exhibit delayed healing due to oxidative stress-induced inflammation and abnormal immune responses. Additionally, the dynamic and wet oral cavity environment complicates stable treatment. To address these challenges, a biomimetic hydrogel adhesive inspired by mussels was developed. This adhesive demonstrates excellent adhesion and mechanical compatibility on oral mucosa in an acidic proinflammatory environment. It also exhibits antioxidative properties by mimicking enzymatic activities to counteract reactive oxygen species-mediated immune disorders. Experimental results on diabetic rat oral wounds showed that this hydrogel adhesive effectively protects against mucosal wounds and accelerates the inflammatory phase, thus promoting wound healing. This study offers a promising therapeutic option to improve the clinical treatment of diabetic oral wounds.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Medicine, General & Internal
Jiwei Sun, Qingming Tang, Shaoling Yu, Mengru Xie, Wenhao Zheng, Guangjin Chen, Ying Yin, Xiaofei Huang, Keqi Wo, Haoqi Lei, Junyuan Zhang, Qian Wan, Lili Chen
Summary: This study reveals that F. nucleatum, a tumor-resident bacterium, accumulates in invasive margins of OSCC tissues and promotes the formation of tumor-associated macrophages (TAMs). Mechanistically, F. nucleatum triggers the GalNAc-Autophagy-TBC1D5 signaling, leading to GLUT1 aggregation in the plasma membrane and the deposition of extracellular lactate. Targeting this process may provide a distinct clinical strategy for patients with advanced OSCC.
Article
Chemistry, Multidisciplinary
Danlei Zhao, Keda Yu, Tingfang Sun, Xirui Jing, Yizhou Wan, Kaifang Chen, Hairui Gao, Yifan Wang, Lili Chen, Xiaodong Guo, Qingsong Wei
Summary: The integration of bio-adaptable performance, elaborate structure, and biological functionality is crucial for degradable bone implants. Innovations in zinc-based bone implants are achieved through material-structure-function integrated additive manufacturing (MSFI-AM), which combines in situ alloying of AM and boundary engineering strategy. These implants demonstrate mechanical self-strengthening and in situ multifunctions, such as augmenting osteogenesis and promoting bone ingrowth and regeneration through sustained release of metal cations and unique structure construction. MSFI-AMed Zn alloy implants show promising clinical translation prospects for load-bearing applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Guangjin Chen, Qingming Tang, Shaoling Yu, Yufeng Shen, Jiwei Sun, Jinfeng Peng, Ying Yin, Guangxia Feng, Xiaofeng Lu, Gang Mei, Yifan Zhang, Qian Wan, Luoying Zhang, Lili Chen
Summary: Excessive exposure to artificial light at night (LAN) can damage the formation of cartilage and impair bone growth. This is due to downregulation of the core circadian clock protein BMAL1, which leads to collagen buildup in the endoplasmic reticulum (ER). Restoring BMAL1 signaling can rescue the dysregulation of cartilage formation caused by LAN exposure, suggesting a potential therapeutic approach for promoting bone growth.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cell Biology
Chenguang Zhang, Yuting Cai, Dang Pengrui, Jiechen Wang, Lu Wang, Jiayun Xu, Yuhan Wu, Wenwen Liu, Lili Chen, Zhengtang Luo, Feilong Deng
Summary: Developing multifunctional nanoparticles for multimodal imaging-guided combination therapy is challenging but highly desirable. In this study, graphene oxide-grafted hollow mesoporous organosilica nanoparticles loaded with doxorubicin and photosensitizers were introduced. Metal oxide nanoparticles grown on the graphene oxide surface served multiple roles in enhancing photothermal efficiency, improving magnetic resonance imaging, increasing photoacoustic imaging sensitivity and specificity, and catalyzing hydrogen peroxide for reactive oxygen species generation. The combination therapy using these nanoparticles successfully suppressed tumors without noticeable side effects, presenting a unique approach to cancer treatment.
CELL PROLIFERATION
(2023)
Article
Cell Biology
Yufeng Shen, Qingming Tang, Jiajia Wang, Zheng Zhou, Ying Yin, Yifan Zhang, Wenhao Zheng, Xinyuan Wang, Guangjin Chen, Jiwei Sun, Lili Chen
Summary: Diabetes mellitus (DM) poses a serious threat to human health and its associated bone regeneration deficiency and nonunion have a significant impact on public health. Activation of retinoic acid-related orphan receptor a (RORa) by SR1078 during early bone defect repair promotes bone regeneration in DM rats. In DM rats, RORa fails to upregulate due to IGF1-AMPK signaling deficiency induced by hyperglycemic inflammatory microenvironment. RORa is crucial for macrophage-induced migration and proliferation of bone mesenchymal stem cells (BMSCs) through CCL3/IL-6 dependent manner.
CELL PROLIFERATION
(2023)
Article
Engineering, Environmental
Zhenhua Wu, Congcan Shi, Yike Li, Aotian Chen, Lili Chen, Bin Su
Summary: This study presents the one-step construction of abrasion-resistant superhydrophilic objects with anisotropic water transport capacities using selective laser sintering. The inserted hydrophilic glass beads and thermoplastic phenol-formaldehyde resin grains form long capillary channels, enabling anisotropic water transport on different surfaces. The superhydrophilic materials also exhibit abrasion resistance and excellent anti-gravity water transport ability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Qian Liu, Irene Lodoso-Torrecilla, Raquel Klein Gunnewiek, Harry R. Harhangi, Antonios G. Mikos, Laura van Niftrik, John A. Jansen, Lili Chen, Jeroen J. J. P. van den Beucken
Summary: In this study, a system was established to achieve different release profiles of the antibiotic drug doxycycline from calcium phosphate cements (CPCs) by adjusting the formulation. The CPC formulations showed appropriate handling properties and released doxycycline with antibacterial activity against Staphylococcus aureus. In vivo implantation experiments demonstrated the effectiveness of the CPC system in local antibacterial therapy.
Review
Biochemistry & Molecular Biology
Xiaofei Huang, Mengru Xie, Xiaofeng Lu, Feng Mei, Wencheng Song, Yang Liu, Lili Chen
Summary: Atherosclerosis is an inflammatory vascular disease that leads to cardiovascular diseases and stroke. Infection, such as periodontitis, has been implicated as a contributing risk factor for atherosclerosis. This review summarizes the prevalent periodontal pathogens found in atherosclerotic plaques, their association with atherosclerosis-related diseases, and the mechanisms by which these pathogens contribute to the progression and destabilization of plaques. Understanding the relationship between periodontal pathogens and atherosclerosis will provide valuable insights and potential therapeutic approaches for its prevention and management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Materials Science, Multidisciplinary
Xian Cheng, Yanping Liu, Ousheng Liu, Yanqin Lu, Zhengwei Liao, Zoya Hadzhieva, Lili Chen, Sander G. C. Leeuwenburgh, Aldo R. Boccaccini, Fang Yang
Summary: Electrophoretic deposition (EPD) is an effective technique for constructing coatings on medical devices, which can be used for local delivery of therapeutic agents. This manuscript provides a comprehensive overview of EPD coatings for drug delivery, with a focus on the mechanism and control over loading and release of therapeutic agents. The different strategies for loading therapeutic agents and factors influencing loading are discussed, as well as the release mechanisms and techniques used to control release kinetics. The applications of therapeutic agent loaded EPD coatings are summarized, and the remaining challenges and future perspectives are reviewed.
PROGRESS IN MATERIALS SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Xinyuan Wang, Qian Liu, Jinfeng Peng, Wencheng Song, Jiajia Zhao, Lili Chen
Summary: Malocclusion, a major disease, affects 56% of oral and systemic health globally. Orthodontics is the primary method, but complications associated with long-term therapy exist. Photobiomodulation (PBM) therapy can shorten orthodontic treatment duration by 26% to 40%. This review evaluates the efficacy, mechanisms, clinical trials, and future developments of PBM therapy in orthodontics, providing evidence-based support for the research and development of light-related orthodontic tooth movement acceleration devices.
Article
Biochemistry & Molecular Biology
Qian Ge, Xinxin Xie, Xiangjun Chen, Rongfeng Huang, Cheng-Xue Rui, Qianna Zhen, Renzhi Hu, Min Wu, Xiaoqiu Xiao, Xi Li
Summary: This study aimed to investigate the role of circulating exosome-like vesicles (ELVs) isolated from individuals with simple obesity in the regulation of beta-cell mass. The results showed that circulating ELVs can act as negative regulators for beta-cell mass in nondiabetic obesity by inhibiting beta-cell proliferation. This effect is associated with downregulated Omentin-1 protein in ELVs.