c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer’s Diseases

Anxiety in rats with bile duct ligation is associated with activation of JNK3 mitogen-activated protein kinase in the hippocampus

(2020) Shamseddin Ahmadi et al.   METABOLIC BRAIN DISEASE

The multiplex model of the genetics of Alzheimer’s disease

(2020) Rebecca Sims et al.   NATURE NEUROSCIENCE

Understanding MAPK Signaling Pathways in Apoptosis

(2020) Jicheng Yue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The JNK inhibitor AS602801 Synergizes with Enzalutamide to Kill Prostate Cancer Cells In Vitro and In Vivo and Inhibit Androgen Receptor Expression

(2020) Zhenghong Li et al.   Translational Oncology

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

(2020) Shorena Janelidze et al.   Nature Communications

A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse

(2020) Min Sung Gee et al.   Alzheimers Research & Therapy

Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

(2020) Forugh S. Dafsari et al.   Translational Psychiatry

Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement

(2020) Seokhwi Kim et al.   Science Advances

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

(2020) Sebastian Palmqvist et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia

(2020) Jose Henrique Ledo et al.   MOLECULAR PSYCHIATRY

Synergy between amyloid-β and tau in Alzheimer’s disease

(2020) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Tau species has potential for Alzheimer disease blood test

(2020) Ian Fyfe   Nature Reviews Neurology

Human fetal microglia acquire homeostatic immune-sensing properties early in development

(2020) L. Kracht et al.   SCIENCE

In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons

(2020) Ramsey Najm et al.   Cell Reports

Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer’s disease

(2020) Jagan A. Pillai et al.   Annals of Clinical and Translational Neurology

Microglia: Agents of the CNS Pro-Inflammatory Response

(2020) José A. Rodríguez-Gómez et al.   Cells

Biological Properties of JNK3 and Its Function in Neurons, Astrocytes, Pancreatic β-Cells and Cardiovascular Cells

(2020) Rei Nakano et al.   Cells

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

(2020) Devika Agarwal et al.   Nature Communications

Efficacy and Safety of AM-111 in the Treatment of Acute Unilateral Sudden Deafness—A Double-blind, Randomized, Placebo-controlled Phase 3 Study

(2019) Hinrich Staecker et al.   OTOLOGY & NEUROTOLOGY

Biomarkers for Alzheimer’s disease beyond amyloid and tau

(2019) Henrik Zetterberg et al.   NATURE MEDICINE

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

(2019) Antoine Daina et al.   NUCLEIC ACIDS RESEARCH

Microglia-mediated neuroinflammation in neurodegenerative diseases

(2019) Charannya Sozheesvari Subhramanyam et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy

(2019) Nicholas C Firth et al.   BRAIN

Alzheimer’s Disease Research Using Human Microglia

(2019) Lue et al.   Cells

A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains

(2019) Vivek Modi et al.   Scientific Reports

Update on biomarkers for amyloid pathology in Alzheimer's disease

(2018) Nicholas J Ashton et al.   Biomarkers in Medicine

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Brimapitide Reduced Neuronal Stress Markers and Cognitive Deficits in 5XFAD Transgenic Mice

(2018) Sarah Gourmaud et al.   JOURNAL OF ALZHEIMERS DISEASE

JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory

(2018) Caroline Morel et al.   JOURNAL OF NEUROSCIENCE

Role of p38/MAPKs in Alzheimer’s disease: implications for amyloid beta toxicity targeted therapy

(2018) Ghazaleh Kheiri et al.   REVIEWS IN THE NEUROSCIENCES

New insights into the structural dynamics of the kinase JNK3

(2018) Pankaj Mishra et al.   Scientific Reports

JNK3 as a Therapeutic Target for Neurodegenerative Diseases

(2018) Xanthi Antoniou et al.   JOURNAL OF ALZHEIMERS DISEASE

Prevalence of Depression in the Community from 30 Countries between 1994 and 2014

(2018) Grace Y. Lim et al.   Scientific Reports

Neuronal MAP kinase p38α inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour

(2018) Kristie Stefanoska et al.   Scientific Reports

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

A Novel and Selective p38 Mitogen-Activated Protein Kinase Inhibitor Attenuates LPS-Induced Neuroinflammation in BV2 Microglia and a Mouse Model

(2018) Min Sung Gee et al.   NEUROCHEMICAL RESEARCH

The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

(2017) Fatima Ardito et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3

(2017) Felix Muth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

(2017) Reisuke H. Takahashi et al.   PATHOLOGY INTERNATIONAL

Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents

(2017) Zdzislaw Chilmonczyk et al.   Pharmacological Reports

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

c-Jun NH 2 -terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study

(2016) Mostafa Hussein et al.   FERTILITY AND STERILITY

A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development

(2016) Feng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis

(2016) Dan Ploug Christensen et al.   Journal of Neuroinflammation

Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease

(2016) Zhe-Min Shi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

(2016) Elise Cuyvers et al.   LANCET NEUROLOGY

TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells

(2016) Michala Prause et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to the Emergence of Oscillatory Behaviour and to Ultrasensitivity

(2016) Aban Shuaib et al.   PLoS One

Mechanism of neurodegeneration through tau and therapy for Alzheimer's disease

(2016) Akihiko Takashima   Journal of Sport and Health Science

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease

(2016) Ramon Yarza et al.   Frontiers in Pharmacology

Longitudinal Association of Dementia and Depression

(2015) Mark B. Snowden et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Role of computer-aided drug design in modern drug discovery

(2015) Stephani Joy Y. Macalino et al.   ARCHIVES OF PHARMACAL RESEARCH

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death

(2015) Rumana Akhter et al.   JOURNAL OF NEUROCHEMISTRY

Subconjunctival Injection of XG-102, a JNK Inhibitor Peptide, in Patients with Intraocular Inflammation: A Safety and Tolerability Study

(2015) Talal Beydoun et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline

(2015) Sarah Gourmaud et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

A historical overview of protein kinases and their targeted small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models

(2015) Stephen S. Palmer et al.   Reproductive Sciences

Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles

(2015) HaJeung Park et al.   Scientific Reports

Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

(2014) Zheng Zhao et al.   ACS Chemical Biology

The Molecular and Systems Biology of Memory

(2014) Eric R. Kandel et al.   CELL

How MAP kinase modules function as robust, yet adaptable, circuits

(2014) Tianhai Tian et al.   CELL CYCLE

Bivalent inhibitors of protein kinases

(2014) Carrie M. Gower et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

(2014) Ramona Rudalska et al.   NATURE MEDICINE

Nuclear and cytosolic JNK signalling in neurons

(2014) Eleanor T. Coffey   NATURE REVIEWS NEUROSCIENCE

Efficacy and Safety of AM-111 in the Treatment of Acute Sensorineural Hearing Loss

(2014) Markus Suckfuell et al.   OTOLOGY & NEUROTOLOGY

Modeling Test and Treatment Strategies for Presymptomatic Alzheimer Disease

(2014) James F. Burke et al.   PLoS One

Dynamic architecture of a protein kinase

(2014) C. L. McClendon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolism and disposition of a potent and selective JNK inhibitor [14C]tanzisertib following oral administration to rats, dogs and humans

(2014) Christian Atsriku et al.   XENOBIOTICA

Kinase Drug Discovery – What’s Next in the Field?

(2013) Philip Cohen et al.   ACS Chemical Biology

On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis

(2013) Michael A. Castello et al.   AGEING RESEARCH REVIEWS

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Ins and Outs of Kinase DFG Motifs

(2013) Daniel K. Treiber et al.   CHEMISTRY & BIOLOGY

Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production

(2013) Alessio Vagnoni et al.   HUMAN MOLECULAR GENETICS

Examination of the Clinicopathologic Continuum of Alzheimer Disease in the Autopsy Cohort of the National Alzheimer Coordinating Center

(2013) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches

(2013) Almudena Fuster-Matanzo et al.   MEDIATORS OF INFLAMMATION

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress

(2012) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

(2012) Timothy Revett et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

(2012) R Killick et al.   MOLECULAR PSYCHIATRY

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

(2012) Sung Ok Yoon et al.   NEURON

The JNK Inhibitor XG-102 Protects against TNBS-Induced Colitis

(2012) Kirstin Reinecke et al.   PLoS One

Stressor-Like Effects of c-Jun N-Terminal Kinase (JNK) Inhibition

(2012) Melanie Clarke et al.   PLoS One

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

(2012) Eric R Kandel   Molecular Brain

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation

(2011) Nicoletta Galeotti et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Moonlighting characteristics of G protein-coupled receptors: Focus on receptor heteromers and relevance for neurodegeneration

(2011) Dasiel O. Borroto-Escuela et al.   IUBMB LIFE

The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria

(2011) Yi Zhao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Protection Against Ischemic Cochlear Damage by Intratympanic Administration of AM-111

(2011) Yoshinori Omotehara et al.   OTOLOGY & NEUROTOLOGY

Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases

(2010) Kenneth M. Comess et al.   ACS Chemical Biology

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

(2010) Gary D. Probst et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

(2010) Sidharth Mehan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Interleukin-1 Receptor Activation by Systemic Lipopolysaccharide Induces Behavioral Despair Linked to MAPK Regulation of CNS Serotonin Transporters

(2010) Chong-Bin Zhu et al.   NEUROPSYCHOPHARMACOLOGY

c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

(2009) Marie A. Bogoyevitch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis

(2009) Danzhi Huang et al.   BIOINFORMATICS

Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

(2009) Fabio Zuccotto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of Muscle c-Jun NH2-Terminal Kinase 1 in Obesity-Induced Insulin Resistance

(2009) G. Sabio et al.   MOLECULAR AND CELLULAR BIOLOGY

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

(2009) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

(2009) Lenka Munoz et al.   NEUROPHARMACOLOGY

Specific activities of individual c-Jun N-terminal kinases in the brain

(2009) W. Haeusgen et al.   NEUROSCIENCE

Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease

(2008) P. D. Bruen et al.   BRAIN

c-Jun N-Terminal Kinase 2 Deficiency Protects Against Hypercholesterolemia-Induced Endothelial Dysfunction and Oxidative Stress

(2008) Elena Osto et al.   CIRCULATION

The β-Arrestin-2 Scaffold Protein Promotes c-Jun N-terminal Kinase-3 Activation by Binding to Its Nonconserved N Terminus

(2008) Chun Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type-II Kinase Inhibitor Docking, Screening, and Profiling Using Modified Structures of Active Kinase States

(2008) Irina Kufareva et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Inhibitors of c-jun-N-Terminal Kinase (JNK)

(2008) Philip LoGrasso et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

D-JNKi, a peptide inhibitor of c-Jun N-terminal kinase, promotes functional recovery after transient focal cerebral ischemia in rats

(2008) E. Esneault et al.   NEUROSCIENCE

Death receptor Fas (CD95) signaling in the central nervous system: tuning neuroplasticity?

(2008) Arno Reich et al.   TRENDS IN NEUROSCIENCES

p38 Kinase Is Activated in the Alzheimer's Disease Brain

(2003) Kenneth Hensley et al.   JOURNAL OF NEUROCHEMISTRY