Dihydrotanshinone, a Natural Diterpenoid, Preserves Blood-Retinal Barrier Integrity via P2X7 Receptor

A New Human Blood–Retinal Barrier Model Based on Endothelial Cells, Pericytes, and Astrocytes

(2020) Claudia G. Fresta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dihydrotanshinone I Alleviates Spinal Cord Injury via Suppressing Inflammatory Response, Oxidative Stress and Apoptosis in Rats

(2020) Liuqian Yu et al.   MEDICAL SCIENCE MONITOR

Novel indole derivatives targeting HuR-mRNA complex to counteract high glucose damage in retinal endothelial cells

(2020) Chiara Bianca Maria Platania et al.   BIOCHEMICAL PHARMACOLOGY

Effects of protein-protein interface disruptors at the ligand of the glucocorticoid-induced tumor necrosis factor receptor-related gene (GITR)

(2020) Chiara Bianca Maria Platania et al.   BIOCHEMICAL PHARMACOLOGY

P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice

(2020) Giovanni Luca Romano et al.   BIOCHEMICAL PHARMACOLOGY

Microfluidics as a Novel Tool for Biological and Toxicological Assays in Drug Discovery Processes: Focus on Microchip Electrophoresis

(2020) Giuseppe Caruso et al.   Micromachines

Highly‐expressed P2X7 receptor promotes growth and metastasis of human HOS/MNNG osteosarcoma cells via PI3K/Akt/GSK3β/β‐catenin and mTOR/HIF1α/VEGF signaling

(2019) Yingchi Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes

(2019) Carmen Clapp et al.   ACTA DIABETOLOGICA

Organ-On-A-Chip Technologies for Advanced Blood–Retinal Barrier Models

(2019) Héloïse Ragelle et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization

(2019) Renyikun Yuan et al.   PHARMACOLOGICAL RESEARCH

Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming Growth Factor-β1

(2019) Sebastiano Alfio Torrisi et al.   Frontiers in Pharmacology

Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents

(2019) Valeria Pittalà et al.   Future Medicinal Chemistry

Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology

(2019) Olvera-Montaño Cecilia et al.   Journal of Diabetes Research

Blood-retinal barrier protection against high glucose damage: The role of P2X7 receptor

(2019) Chiara Bianca Maria Platania et al.   BIOCHEMICAL PHARMACOLOGY

Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization

(2019) Alanna E. McCarthy et al.   CELL

Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase

(2019) Yasumitsu Sakamoto et al.   Scientific Reports

Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages

(2019) Giuseppe Caruso et al.   Antioxidants

Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease

(2019) Shiv Bharadwaj et al.   Scientific Reports

Diabetic retinopathy and endothelin system: microangiopathy versus endothelial dysfunction

(2018) Francesco Saverio Sorrentino et al.   EYE

Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders

(2018) Anindya Bhattacharya   Frontiers in Pharmacology

Non-nucleotide Agonists Triggering P2X7 Receptor Activation and Pore Formation

(2018) Francesco Di Virgilio et al.   Frontiers in Pharmacology

Importance of integrity of cell-cell junctions for the mechanics of confluent MDCK II cells

(2018) Bastian Rouven Brückner et al.   Scientific Reports

Long-term efficacy and safety profile of multiple injections of intravitreal dexamethasone implant to manage diabetic macular edema: A systematic review of real-world studies

(2018) Claudio Bucolo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Hypoxic expression of NLRP3 and VEGF in cultured retinal pigment epithelial cells: contribution of P2Y2 receptor signaling

(2018) Fabian Doktor et al.   Purinergic Signalling

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

(2017) Eleonora Aronica et al.   EPILEPSIA

Interplay between tight junctions & adherens junctions

(2017) Hannah K. Campbell et al.   EXPERIMENTAL CELL RESEARCH

Ischemic Retinopathies: Oxidative Stress and Inflammation

(2017) José Carlos Rivera et al.   Oxidative Medicine and Cellular Longevity

The inner blood-retinal barrier: Cellular basis and development

(2017) Mónica Díaz-Coránguez et al.   VISION RESEARCH

Association between Aqueous Cytokines and Diabetic Retinopathy Stage

(2017) Hailiang Wu et al.   Journal of Ophthalmology

The P2X7 Receptor-Interleukin-1 Liaison

(2017) Anna Lisa Giuliani et al.   Frontiers in Pharmacology

Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review

(2016) Daniel Shu Wei Ting et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

VIP Family Members Prevent Outer Blood Retinal Barrier Damage in a Model of Diabetic Macular Edema

(2016) Grazia Maugeri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Claudins in cancer: bench to bedside

(2016) Makoto Osanai et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation

(2016) Choon-Soo Lee et al.   Scientific Reports

P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2

(2015) M. Adamczyk et al.   JOURNAL OF CELL SCIENCE

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

(2015) Vito Giuseppe D’Agostino et al.   Scientific Reports

Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy

(2015) Jianbo He et al.   Journal of Ophthalmology

Hyperglycemia Induces Toll-Like Receptor-2 and -4 Expression and Activity in Human Microvascular Retinal Endothelial Cells: Implications for Diabetic Retinopathy

(2015) Uthra Rajamani et al.   Journal of Diabetes Research

Purines in the eye: Recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland

(2014) Julie Sanderson et al.   EXPERIMENTAL EYE RESEARCH

Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain

(2014) Jonathan M. Beckel et al.   GLIA

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567

(2013) Anindya Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

(2013) David Križaj et al.   CURRENT EYE RESEARCH

VEGF but not PlGF disturbs the barrier of retinal endothelial cells

(2013) Heidrun L. Deissler et al.   EXPERIMENTAL EYE RESEARCH

Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1

(2011) Katherine E. Trueblood et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A novel co-culture model of the blood-retinal barrier based on primary retinal endothelial cells, pericytes and astrocytes

(2011) Joanna Wisniewska-Kruk et al.   EXPERIMENTAL EYE RESEARCH

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Blood-Retinal Barrier

(2010) José Cunha-Vaz et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Peroxynitrite Mediates Diabetes-Induced Endothelial Dysfunction: Possible Role of Rho Kinase Activation

(2010) Azza B. El-Remessy et al.   Experimental Diabetes Research

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

(2009) Werner J.H. Koopman et al.   ANTIOXIDANTS & REDOX SIGNALING