Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer
出版年份 2021 全文链接
标题
Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer
作者
关键词
ABT-263 (Navitoclax), ABT-199 (Venetoclax), B-Cell lymphoma 2 (BCL-2), DNA methylation, DNA methyltransferase (DNMT), Dynamin-related protein 1 (Drp1), Group 1 pulmonary hypertension, Hypoxia-inducible factor 1α (HIF-1α), Pyruvate dehydrogenase kinase (PDK), Pyruvate kinase muscle isoform 2 (PKM2), Reactive oxygen species (ROS), Sugen5416, Survivin, von hippel-lindau protein (VHL)
出版物
FREE RADICAL BIOLOGY AND MEDICINE
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2021-01-14
DOI
10.1016/j.freeradbiomed.2020.12.452
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications
- (2020) Asish Dasgupta et al. FASEB JOURNAL
- Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells
- (2020) Quan Yuan et al. OncoTargets and Therapy
- Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis
- (2020) Lian Tian et al. CIRCULATION RESEARCH
- Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension
- (2020) Sasha Z. Prisco et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- HIF Inhibitors: Status of Current Clinical Development
- (2019) Jaleh Fallah et al. Current Oncology Reports
- Ndufs2, A Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction
- (2019) Kimberly J Dunham-Snary et al. CIRCULATION RESEARCH
- Dichloroacetate Affects Mitochondrial Function and Stemness-Associated Properties in Pancreatic Cancer Cell Lines
- (2019) Tataranni et al. Cells
- Mitochondrial fission requires DRP1 but not dynamins
- (2019) Tiago Branco Fonseca et al. NATURE
- Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer
- (2019) Timothy J Humpton et al. Cancer Discovery
- Diverse Stakeholders of Tumor Metabolism: An Appraisal of the Emerging Approach of Multifaceted Metabolic Targeting by 3-Bromopyruvate
- (2019) Saveg Yadav et al. Frontiers in Pharmacology
- Dynamics of Dynamin-Related Protein 1 in Alzheimer’s Disease and Other Neurodegenerative Diseases
- (2019) Darryll Oliver et al. Cells
- Novel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis
- (2019) Yu-Wei Lin et al. BMC CANCER
- Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer
- (2019) Sandhya Yadav et al. BMC CANCER
- ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease
- (2019) Qian Zhang et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- DRP1 upregulation promotes pancreatic cancer growth and metastasis through increased aerobic glycolysis
- (2019) Jing Liang et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications
- (2019) Tiziana Tataranni et al. Oxidative Medicine and Cellular Longevity
- Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury
- (2019) Danchen Wu et al. FASEB JOURNAL
- Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in PAH with HIF-2α Inhibitor
- (2018) Zhiyu Dai et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Acute O 2 Sensing: Role of Coenzyme QH 2 /Q Ratio and Mitochondrial ROS Compartmentalization
- (2018) Ignacio Arias-Mayenco et al. Cell Metabolism
- Mitofusin-2 Triggers Cervical Carcinoma Cell Hela Apoptosis via Mitochondrial Pathway in Mouse Model
- (2018) Weiqiong Wang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension
- (2018) Kuang-Hueih Chen et al. CIRCULATION
- Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer
- (2018) Nicholas S. Akins et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay
- (2018) Taimour Langaee et al. Genetic Testing and Molecular Biomarkers
- The role of the mitochondrial calcium uniporter (MCU) complex in cancer
- (2018) Adina Vultur et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Pulmonary arterial hypertension: pathogenesis and clinical management
- (2018) Thenappan Thenappan et al. BMJ-British Medical Journal
- Pulmonary arterial hypertension: pathogenesis and clinical management
- (2018) Thenappan Thenappan et al. BMJ-British Medical Journal
- Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension
- (2018) Lian Tian et al. Frontiers in Physiology
- Dynamin-Related Protein 1 at the Crossroads of Cancer
- (2018) Ana Rita Lima et al. Genes
- The Role of Mitophagy in Innate Immunity
- (2018) Ilias Gkikas et al. Frontiers in Immunology
- Yap promotes hepatocellular carcinoma metastasis and mobilization via governing cofilin/F-actin/lamellipodium axis by regulation of JNK/Bnip3/SERCA/CaMKII pathways
- (2018) Chen Shi et al. Redox Biology
- Chronic hypoxia-induced slug promotes invasive behavior of prostate cancer cells by activating expression of ephrin-B1
- (2018) Kazunori Iwasaki et al. CANCER SCIENCE
- PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism
- (2018) Changfeng Li et al. DEVELOPMENTAL CELL
- Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria
- (2018) In-geun Ryoo et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
- (2018) Yun Zhang et al. Frontiers of Medicine
- Haemodynamic definitions and updated clinical classification of pulmonary hypertension
- (2018) Gérald Simonneau et al. EUROPEAN RESPIRATORY JOURNAL
- Clinical trial design and new therapies for pulmonary arterial hypertension
- (2018) Olivier Sitbon et al. EUROPEAN RESPIRATORY JOURNAL
- Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis
- (2017) Shuhua Shan et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Mitochondria-Division Inhibitor 1 Protects Against Amyloid-β induced Mitochondrial Fragmentation and Synaptic Damage in Alzheimer’s Disease
- (2017) P. Hemachandra Reddy et al. JOURNAL OF ALZHEIMERS DISEASE
- Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions
- (2017) Hoi-Shan Wong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension
- (2017) Lian Tian et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Docetaxel Reverses Pulmonary Vascular Remodeling by Decreasing Autophagy and Resolves Right Ventricular Fibrosis
- (2017) Yasmine F. Ibrahim et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- miR-361-5p modulates metabolism and autophagy via the Sp1-mediated regulation of PKM2 in prostate cancer
- (2017) Zhixin Ling et al. ONCOLOGY REPORTS
- Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect
- (2017) Smriti Singh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
- (2017) Evangelos D. Michelakis et al. Science Translational Medicine
- Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
- (2017) Juan Liu et al. Nature Communications
- MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in cervical cancer
- (2017) Man Guo et al. Oncotarget
- Novel post-transcriptional and post-translational regulation of pro-apoptotic protein BOK and anti-apoptotic protein Mcl-1 determine the fate of breast cancer cells to survive or die
- (2017) Benjamin Onyeagucha et al. Oncotarget
- IGF-1-mediated PKM2/β-catenin/miR-152 regulatory circuit in breast cancer
- (2017) Yi-Yang Wen et al. Scientific Reports
- Redox signaling in acute oxygen sensing
- (2017) Lin Gao et al. Redox Biology
- MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling
- (2017) Ke Xu et al. Scientific Reports
- The principal pathways involved in thein vivomodulation of hypoxic pulmonary vasoconstriction, pulmonary arterial remodelling and pulmonary hypertension
- (2016) D. Kylhammar et al. Acta Physiologica
- Suppression of endothelial PGC-1α is associated with hypoxia-induced endothelial dysfunction and provides a new therapeutic target in pulmonary arterial hypertension
- (2016) Jia-Xin Ye et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Differential regulation of autophagy and mitophagy in pulmonary diseases
- (2016) Saurabh Aggarwal et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension
- (2016) Adeleye J. Afolayan et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension
- (2016) Lydie Plecitá-Hlavatá et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- The Essential Role of Drp1 and Its Regulation by S-Nitrosylation of Parkin in Dopaminergic Neurodegeneration: Implications for Parkinson's Disease
- (2016) Zhenzhen Zhang et al. ANTIOXIDANTS & REDOX SIGNALING
- PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma
- (2016) S. Agnihotri et al. CANCER RESEARCH
- Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells
- (2016) C.-T. Cheng et al. CANCER RESEARCH
- Carfilzomib reverses pulmonary arterial hypertension
- (2016) Xinhong Wang et al. CARDIOVASCULAR RESEARCH
- Epithelial-mesenchymal transition in tissue repair and fibrosis
- (2016) Rivka C. Stone et al. CELL AND TISSUE RESEARCH
- Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2αCLINICAL PERSPECTIVE
- (2016) Zhiyu Dai et al. CIRCULATION
- The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease
- (2016) K. Atkins et al. CLINICAL SCIENCE
- Regulators of mitochondrial dynamics in cancer
- (2016) Daniela Senft et al. CURRENT OPINION IN CELL BIOLOGY
- The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α
- (2016) Anna Tosatto et al. EMBO Molecular Medicine
- Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis
- (2016) Xiao-Qing Sun et al. HYPERTENSION RESEARCH
- Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission
- (2016) Haili Wu et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer
- (2016) Jian Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Clinical and Biological Insights Into Combined Post- and Pre-Capillary Pulmonary Hypertension
- (2016) Tufik R. Assad et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Multiple dynamin family members collaborate to drive mitochondrial division
- (2016) Jason E. Lee et al. NATURE
- A PGC1α-mediated transcriptional axis suppresses melanoma metastasis
- (2016) Chi Luo et al. NATURE
- The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
- (2016) Veronica Torrano et al. NATURE CELL BIOLOGY
- SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions
- (2016) Abhishek Bhardwaj et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clinical significance of mitofusin-2 and its signaling pathways in hepatocellular carcinoma
- (2016) Yingsheng Wu et al. World Journal of Surgical Oncology
- PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors
- (2016) Kohei Taniguchi et al. Oncotarget
- AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth
- (2016) Young Soo Park et al. Oncotarget
- Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP
- (2016) Emily Filichia et al. Scientific Reports
- Hypoxic Pulmonary Vasoconstriction
- (2015) Andrew B. Lumb et al. ANESTHESIOLOGY
- Endothelial Uncoupling Protein 2 Regulates Mitophagy and Pulmonary Hypertension During Intermittent Hypoxia
- (2015) M. Haslip et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Mitochondrial Ca2+ uniporter is critical for store-operated Ca2+ entry-dependent breast cancer cell migration
- (2015) Shihao Tang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer
- (2015) Kohei Taniguchi et al. CANCER LETTERS
- Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis
- (2015) Justin V. Joseph et al. CANCER LETTERS
- MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells
- (2015) Patricia Sancho et al. Cell Metabolism
- BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension
- (2015) Isabel Diebold et al. Cell Metabolism
- Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension
- (2015) John J. Ryan et al. CIRCULATION
- Maintaining Ancient Organelles: Mitochondrial Biogenesis and Maturation
- (2015) R. B. Vega et al. CIRCULATION RESEARCH
- Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis
- (2015) A. H. Chourasia et al. EMBO REPORTS
- A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors
- (2015) Quincy Siu-Chung Chu et al. INVESTIGATIONAL NEW DRUGS
- Mechanism of Activation-Induced Downregulation of Mitofusin 2 in Human Peripheral Blood T Cells
- (2015) Asish Dasgupta et al. JOURNAL OF IMMUNOLOGY
- The mitochondrial Ca2+ uniporter complex
- (2015) J. Kevin Foskett et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Management of Pulmonary Arterial Hypertension
- (2015) Vallerie V. McLaughlin et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma
- (2015) Yuqing Lou et al. MEDICAL ONCOLOGY
- Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1
- (2015) Seung Baek Lee et al. MOLECULAR CELL
- Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors
- (2015) Madhavika N. Serasinghe et al. MOLECULAR CELL
- Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth
- (2015) Jennifer A. Kashatus et al. MOLECULAR CELL
- Mitochondrial control by DRP1 in brain tumor initiating cells
- (2015) Qi Xie et al. NATURE NEUROSCIENCE
- Regulatory circuit of PKM2/NF-κB/miR-148a/152-modulated tumor angiogenesis and cancer progression
- (2015) Q Xu et al. ONCOGENE
- A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus
- (2015) Kimberly J. Dunham-Snary et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Store-Operated Calcium Channels
- (2015) Murali Prakriya et al. PHYSIOLOGICAL REVIEWS
- Mitochondrial Dynamics Protein Drp1 Is Overexpressed in Oncocytic Thyroid Tumors and Regulates Cancer Cell Migration
- (2015) André Ferreira-da-Silva et al. PLoS One
- Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers
- (2015) Shruti Desai et al. Oncotarget
- Regulation of the Warburg Effect in Early-Passage Breast Cancer Cells
- (2015) Ian F. Robey et al. NEOPLASIA
- HIF2A and IGF2 Expression Correlates in Human Neuroblastoma Cells and Normal Immature Sympathetic Neuroblasts
- (2015) Sofie Mohlin et al. NEOPLASIA
- Regulation of autophagy and mitophagy by nutrient availability and acetylation
- (2014) Bradley R. Webster et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation
- (2014) Gopinath Sutendra et al. CELL
- Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation
- (2014) Prashant Mishra et al. Cell Metabolism
- Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension
- (2014) Marc Humbert et al. CIRCULATION
- The Right Ventricle in Pulmonary Arterial Hypertension
- (2014) John J. Ryan et al. CIRCULATION RESEARCH
- Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission
- (2014) P. Hemachandra Reddy DRUG DISCOVERY TODAY
- Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells
- (2014) XIAO-JIAN HAN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The Pyruvate Dehydrogenase Complexes: Structure-based Function and Regulation
- (2014) Mulchand S. Patel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer
- (2014) Edward B. Garon et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The Role of TWIST in Ovarian Epithelial Cancers
- (2014) Kyungbin Kim et al. Korean Journal of Pathology
- PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
- (2014) Valerie S. LeBleu et al. NATURE CELL BIOLOGY
- miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma
- (2014) Angela M. Liu et al. PLoS One
- Mitochondrial Calcium Uniporter Activity Is Dispensable for MDA-MB-231 Breast Carcinoma Cell Survival
- (2014) Duane D. Hall et al. PLoS One
- Signaling mechanisms of the epithelial-mesenchymal transition
- (2014) D. M. Gonzalez et al. Science Signaling
- Mechanism of the Susceptibility of Remodeled Pulmonary Vessels to Drug‐Induced Cell Killing
- (2014) Yasmine F. Ibrahim et al. Journal of the American Heart Association
- Metabolism and Bioenergetics in the Right Ventricle and Pulmonary Vasculature in Pulmonary Hypertension
- (2014) Stephen L. Archer et al. Pulmonary Circulation
- Everolimus in Patients with Severe Pulmonary Hypertension: A Safety and Efficacy Pilot Trial
- (2014) Hans-Jürgen Seyfarth et al. Pulmonary Circulation
- Activated PAR-2 Regulates Pancreatic Cancer Progression through ILK/HIF-α–Induced TGF-α Expression and MEK/VEGF-A–Mediated Angiogenesis
- (2013) Li-Hsun Chang et al. AMERICAN JOURNAL OF PATHOLOGY
- PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension
- (2013) John J. Ryan et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension
- (2013) Amal Houssaini et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells
- (2013) Merril C. Curry et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2)
- (2013) Yong Xu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
- (2013) Francisca Vazquez et al. CANCER CELL
- Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line
- (2013) Felicity M Davis et al. Cancer Cell International
- Gap junctions support the sustained phase of hypoxic pulmonary vasoconstriction by facilitating calcium sensitization
- (2013) Igor V. Kizub et al. CARDIOVASCULAR RESEARCH
- Participation of mitochondrial fission during mitophagy
- (2013) Kai Mao et al. CELL CYCLE
- Nuclear PKM2 regulates the Warburg effect
- (2013) Weiwei Yang et al. CELL CYCLE
- Heterogeneity in Lung 18 FDG Uptake in Pulmonary Arterial Hypertension
- (2013) Lan Zhao et al. CIRCULATION
- Uncoupling Protein 2 Deficiency Mimics the Effects of Hypoxia and Endoplasmic Reticulum Stress on Mitochondria and Triggers Pseudohypoxic Pulmonary Vascular Remodeling and Pulmonary Hypertension
- (2013) Peter Dromparis et al. CIRCULATION RESEARCH
- Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung
- (2013) Sara K. Berkelhamer et al. FREE RADICAL BIOLOGY AND MEDICINE
- Anti-Tumor Effects of Mfn2 in Gastric Cancer
- (2013) Ge-Er Zhang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors
- (2013) E. M. Dunbar et al. INVESTIGATIONAL NEW DRUGS
- Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration
- (2013) Xing Guo et al. JOURNAL OF CLINICAL INVESTIGATION
- Apoptosis therapy: driving cancers down the road to ruin
- (2013) Douglas R. Green et al. NATURE MEDICINE
- Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases
- (2013) Stephen L. Archer NEW ENGLAND JOURNAL OF MEDICINE
- Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch
- (2013) J B Tennakoon et al. ONCOGENE
- Slug is a key mediator of hypoxia induced cadherin switch in HNSCC: Correlations with poor prognosis
- (2013) Jiali Zhang et al. ORAL ONCOLOGY
- JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism
- (2013) H.-J. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
- (2013) Y. Chen et al. SCIENCE
- New mechanisms of pulmonary arterial hypertension: role of Ca2+ signaling
- (2012) Frank K. Kuhr et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Lung18F-Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Pulmonary Arterial Hypertension
- (2012) Glenn Marsboom et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Hydrogen Peroxide Sensing and Signaling by Protein Kinases in the Cardiovascular System
- (2012) Joseph R. Burgoyne et al. ANTIOXIDANTS & REDOX SIGNALING
- Identifying miRNAs, targets and functions
- (2012) B. Liu et al. BRIEFINGS IN BIOINFORMATICS
- PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
- (2012) Weiwei Yang et al. CELL
- The pathways of mitophagy for quality control and clearance of mitochondria
- (2012) G Ashrafi et al. CELL DEATH AND DIFFERENTIATION
- Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension
- (2012) Glenn Marsboom et al. CIRCULATION RESEARCH
- Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension
- (2012) Jose Gomez-Arroyo et al. Circulation-Heart Failure
- Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25
- (2012) Saverio Marchi et al. CURRENT BIOLOGY
- Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer
- (2012) Jalees Rehman et al. FASEB JOURNAL
- Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage
- (2012) M. Manczak et al. HUMAN MOLECULAR GENETICS
- Case Report: Sodium dichloroacetate (DCA) inhibition of the “Warburg Effect” in a human cancer patient: complete response in non-Hodgkin’s lymphoma after disease progression with rituximab-CHOP
- (2012) Stephen B. Strum et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions
- (2012) Casey L. Quinlan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity
- (2012) X. Qi et al. JOURNAL OF CELL SCIENCE
- FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate
- (2012) Lin Piao et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension
- (2012) Irina Enache et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis
- (2012) Guillaume P. Leboucher et al. MOLECULAR CELL
- ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
- (2012) Weiwei Yang et al. NATURE CELL BIOLOGY
- Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
- (2012) Dimitrios Anastasiou et al. Nature Chemical Biology
- Mitochondrial dynamics regulates migration and invasion of breast cancer cells
- (2012) J Zhao et al. ONCOGENE
- miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect
- (2012) YAN SUN et al. ONCOLOGY REPORTS
- Interactions between the C-terminus of Kv1.5 and Kvβ regulate pyridine nucleotide-dependent changes in channel gating
- (2012) Srinivas M. Tipparaju et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Puerarin Induces Mitochondria-Dependent Apoptosis in Hypoxic Human Pulmonary Arterial Smooth Muscle Cells
- (2012) Chan Chen et al. PLoS One
- Shifting the balance of mitochondrial apoptosis: therapeutic perspectives
- (2012) Simone Fulda Frontiers in Oncology
- Mitochondrial Biogenesis Drives Tumor Cell Proliferation
- (2011) Ubaldo E. Martinez-Outschoorn et al. AMERICAN JOURNAL OF PATHOLOGY
- 18F-FDG PET/CT imaging in oncology
- (2011) Ahmad Almuhaideb et al. ANNALS OF SAUDI MEDICINE
- Mitochondrial Regulation of Cell Cycle and Proliferation
- (2011) Valeria Gabriela Antico Arciuch et al. ANTIOXIDANTS & REDOX SIGNALING
- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
- (2011) J. Schodel et al. BLOOD
- Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells
- (2011) Roberta Mazzieri et al. CANCER CELL
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
- (2011) Weibo Luo et al. CELL
- Chronic Exposure to Arsenic Causes Increased Cell Survival, DNA Damage, and Increased Expression of Mitochondrial Transcription Factor A (mtTFA) in Human Prostate Epithelial Cells
- (2011) Kamaleshwar P. Singh et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation
- (2011) Mariusz Karbowski et al. CURRENT OPINION IN CELL BIOLOGY
- MiD49 and MiD51, new components of the mitochondrial fission machinery
- (2011) Catherine S Palmer et al. EMBO REPORTS
- Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
- (2011) Maria Manczak et al. HUMAN MOLECULAR GENETICS
- Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
- (2011) Joshua M. Baughman et al. NATURE
- Treatment of HER2-positive breast cancer: current status and future perspectives
- (2011) Carlos L. Arteaga et al. Nature Reviews Clinical Oncology
- Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
- (2011) J Chen et al. ONCOGENE
- ER Tubules Mark Sites of Mitochondrial Division
- (2011) J. R. Friedman et al. SCIENCE
- The Role of Nogo and the Mitochondria-Endoplasmic Reticulum Unit in Pulmonary Hypertension
- (2011) G. Sutendra et al. Science Translational Medicine
- The transient receptor potential family of ion channels
- (2011) Bernd Nilius et al. GENOME BIOLOGY
- Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells
- (2010) Lili Jiang et al. BMC CANCER
- Hypoxia-induced CCR7 expression via HIF-1α and HIF-2α correlates with migration and invasion in lung cancer cells
- (2010) Yang Li et al. CANCER BIOLOGY & THERAPY
- HIF-1α and HIF-2α correlate with migration and invasion in gastric cancer
- (2010) Yanxia Wang et al. CANCER BIOLOGY & THERAPY
- Endocytosis unplugged: multiple ways to enter the cell
- (2010) Sudha Kumari et al. CELL RESEARCH
- Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension
- (2010) Stephen L. Archer et al. CIRCULATION
- Regulation of mitochondrial biogenesis
- (2010) François R. Jornayvaz et al. Essays in Biochemistry
- Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
- (2010) Hidenori Otera et al. JOURNAL OF CELL BIOLOGY
- The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
- (2010) Michele M. Hickey et al. JOURNAL OF CLINICAL INVESTIGATION
- Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma
- (2010) Baiye Jin et al. MEDICAL ONCOLOGY
- Aberrant mitochondrial fission in neurons induced by protein kinase Cδ under oxidative stress conditions in vivo
- (2010) Xin Qi et al. MOLECULAR BIOLOGY OF THE CELL
- PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis
- (2010) A Bender et al. ONCOGENE
- Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
- (2010) F. Weinberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of Mitochondrial Gene Deletion on Tumorigenicity of Metastatic Melanoma: Reassessing the Warburg Effect
- (2010) Michael V. Berridge et al. REJUVENATION RESEARCH
- The role of redox changes in oxygen sensing
- (2010) E. Kenneth Weir et al. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
- Metabolic Modulation of Glioblastoma with Dichloroacetate
- (2010) E. D. Michelakis et al. Science Translational Medicine
- Expression of mitochondrial transcription factor A in endometrial carcinomas: clinicopathologic correlations and prognostic significance
- (2010) Naoyuki Toki et al. VIRCHOWS ARCHIV
- The Role of Mitochondria in Apoptosis
- (2009) Chunxin Wang et al. Annual Review of Genetics
- ROS-Dependent Signaling Mechanisms for Hypoxic Ca2+ Responses in Pulmonary Artery Myocytes
- (2009) Yong-Xiao Wang et al. ANTIOXIDANTS & REDOX SIGNALING
- Identification of small molecule inhibitors of pyruvate kinase M2
- (2009) Matthew G. Vander Heiden et al. BIOCHEMICAL PHARMACOLOGY
- Endothelial deletion of hypoxia-inducible factor-2 (HIF-2 ) alters vascular function and tumor angiogenesis
- (2009) N. Skuli et al. BLOOD
- Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features
- (2009) Esther A Koop et al. BMC CANCER
- Importing Mitochondrial Proteins: Machineries and Mechanisms
- (2009) Agnieszka Chacinska et al. CELL
- Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells
- (2009) Gregory B. Waypa et al. CIRCULATION RESEARCH
- Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
- (2009) David R. Mole et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle
- (2009) Lin Piao et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Interacts with the Androgen Receptor (AR) and Promotes Prostate Cancer Cell Growth by Activating the AR
- (2009) Masaki Shiota et al. MOLECULAR ENDOCRINOLOGY
- HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
- (2009) Charles J. David et al. NATURE
- Manganese Superoxide Dismutase Modulates Hypoxia-Inducible Factor-1 Induction via Superoxide
- (2008) S. Kaewpila et al. CANCER RESEARCH
- In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function
- (2008) Amelia Barilli et al. CARDIOVASCULAR RESEARCH
- MicroRNA Expression Profiles in Serous Ovarian Carcinoma
- (2008) E. J. Nam et al. CLINICAL CANCER RESEARCH
- Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization
- (2008) Ann Cassidy-Stone et al. DEVELOPMENTAL CELL
- Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells
- (2008) Michael J. Hitchler et al. FREE RADICAL BIOLOGY AND MEDICINE
- Dichloroacetate induces apoptosis in endometrial cancer cells
- (2008) Jason Y.Y. Wong et al. GYNECOLOGIC ONCOLOGY
- Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation
- (2008) Gilles A. Spoden et al. INTERNATIONAL JOURNAL OF CANCER
- Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling
- (2008) Thian-Sze Wong et al. INTERNATIONAL JOURNAL OF CANCER
- MicroRNA profiling in human medulloblastoma
- (2008) Elisabetta Ferretti et al. INTERNATIONAL JOURNAL OF CANCER
- CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology
- (2008) Xiao-Jian Han et al. JOURNAL OF CELL BIOLOGY
- Ubiquitin–Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion
- (2008) Mickael M.J. Cohen et al. MOLECULAR BIOLOGY OF THE CELL
- The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells
- (2008) Shilpa Gandre-Babbe et al. MOLECULAR BIOLOGY OF THE CELL
- Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing
- (2008) Michael Zimmer et al. MOLECULAR CELL
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- Direct regulation of TWIST by HIF-1α promotes metastasis
- (2008) Muh-Hwa Yang et al. NATURE CELL BIOLOGY
- Parkin as a tumor suppressor gene for hepatocellular carcinoma
- (2008) M Fujiwara et al. ONCOGENE
- Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
- (2008) E B Rankin et al. ONCOGENE
- Dichloroacetate (DCA) sensitizes both wild‐type and over expressingBcl‐2prostate cancer cells in vitro to radiation
- (2008) Wengang Cao et al. PROSTATE
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