Effect of Partially FluorinatedN-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties

Accurate Lipophilicity (log P ) Measurements Inform on Subtle Stereoelectronic Effects in Fluorine Chemistry

(2016) David O'Hagan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method

(2015) Bruno Linclau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

(2015) Quentin A. Huchet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modern Carbon–Fluorine Bond Forming Reactions for Aryl Fluoride Synthesis

(2014) Michael G. Campbell et al.   CHEMICAL REVIEWS

Enantioselective Synthesis and Physicochemical Properties of Libraries of 3-Amino- and 3-Amidofluoropiperidines

(2014) Aurélie Orliac et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Computational Study of Vicinal Fluorination in 2,3-Difluorobutane: Implications for Conformational Control in Alkane Chains

(2014) Stephen J. Fox et al.   CHEMISTRY-A EUROPEAN JOURNAL

Simple Vector Considerations to Assess the Polarity of Partially Fluorinated Alkyl and Alkoxy Groups

(2014) Klaus Müller   CHIMIA

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On the polarity of partially fluorinated methyl groups

(2013) Quentin A. Huchet et al.   JOURNAL OF FLUORINE CHEMISTRY

Enabling Nucleophilic Substitution Reactions of Activated Alkyl Fluorides through Hydrogen Bonding

(2013) Pier Alexandre Champagne et al.   ORGANIC LETTERS

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

(2010) Anh P. Truong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors

(2010) Leonardo Pisani et al.   ChemMedChem

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Oxetanes in Drug Discovery: Structural and Synthetic Insights

(2010) Georg Wuitschik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tetrabutylammonium Tetra(tert-Butyl Alcohol)-Coordinated Fluoride as a Facile Fluoride Source

(2008) Dong Wook Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AnN,N′-Dioxide/In(OTf)3 Catalyst for the Asymmetric Hetero-Diels–Alder Reaction Between Danishefsky's Dienes and Aldehydes: Application in the Total Synthesis of Triketide

(2008) Zhipeng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION