A Review of the Neural Mechanisms of Action and Clinical Efficiency of Riluzole in Treating Amyotrophic Lateral Sclerosis: What have we Learned in the Last Decade?

Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na+currents

(2009) Marcello D’Ascenzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus

(2009) R. Katoh-Semba et al.   NEUROSCIENCE

Riluzole protects against glutamate-induced slowing of neurofilament axonal transport

(2009) Alison Stevenson et al.   NEUROSCIENCE LETTERS

Early treatment with noninvasive positive pressure ventilation prolongs survival in Amyotrophic Lateral Sclerosis patients with nocturnal respiratory insufficiency

(2009) Pierluigi Carratù et al.   Orphanet Journal of Rare Diseases

A riluzole- and valproate-sensitive persistent sodium current contributes to the resting membrane potential and increases the excitability of sympathetic neurones

(2009) J. Antonio Lamas et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice

(2008) Steven J. Del Signore et al.   Amyotrophic Lateral Sclerosis

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis

(2008) Steve Vucic et al.   BRAIN

Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: The NNIPPS Study

(2008) Gilbert Bensimon et al.   BRAIN

Riluzole in the Treatment of Mood and Anxiety Disorders

(2008) Christopher Pittenger et al.   CNS DRUGS

Riluzole blocks persistent Na+and Ca2+currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneuronsin vitro

(2008) Nerijus Lamanauskas et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis

(2008) Massimo Pieri et al.   EXPERIMENTAL NEUROLOGY

Riluzole in psychiatry: a systematic review of the literature

(2008) Carlos A Zarate et al.   Expert Opinion on Drug Metabolism & Toxicology

The fraction of activated N-methyl-d-Aspartate receptors during synaptic transmission remains constant in the presence of the glutamate release inhibitor riluzole

(2008) G. Rammes et al.   JOURNAL OF NEURAL TRANSMISSION

Persistent Sodium Current Contributes to Induced Voltage Oscillations in Locomotor-Related Hb9 Interneurons in the Mouse Spinal Cord

(2008) Lea Ziskind-Conhaim et al.   JOURNAL OF NEUROPHYSIOLOGY

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis

(2008) B. van Zundert et al.   JOURNAL OF NEUROSCIENCE

The Persistent Sodium Current Generates Pacemaker Activities in the Central Pattern Generator for Locomotion and Regulates the Locomotor Rhythm

(2008) S. Tazerart et al.   JOURNAL OF NEUROSCIENCE

Direct Effects of Riluzole on 5-Hydroxytryptamine (5-HT)3 Receptor–Activated Ion Currents in NCB-20 Neuroblastoma Cells

(2008) Ki Jung Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a New Activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the Endothelium-Derived Hyperpolarizing Factor Response and Lowers Blood Pressure

(2008) A. Sankaranarayanan et al.   MOLECULAR PHARMACOLOGY

Molecular mechanisms of interaction between the neuroprotective substance riluzole and GABAA-receptors

(2008) K. Jahn et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Control of Presynaptic Function by a Persistent Na+ Current

(2008) Hai Huang et al.   NEURON

Riluzole Increases the Amount of Latent HSF1 for an Amplified Heat Shock Response and Cytoprotection

(2008) Jingxian Yang et al.   PLoS One

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY

Eupnea of in situ rats persists following blockers of in vitro pacemaker burster activities

(2008) Walter M. St.-John   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1

(2007) Elena Fumagalli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells

(2007) Ya-Jean Wang et al.   LIFE SCIENCES