标题
Development of Mcl-1 inhibitors for cancer therapy
作者
关键词
-
出版物
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 210, Issue -, Pages 113038
出版商
Elsevier BV
发表日期
2020-11-24
DOI
10.1016/j.ejmech.2020.113038
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins
- (2020) Karson J. Kump et al. JOURNAL OF MEDICINAL CHEMISTRY
- Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization
- (2020) Feng Gao et al. Cell Death & Disease
- Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors
- (2020) Lulu Liu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structure-based virtual screening, biological evaluation and biophysical study of novel Mcl-1 inhibitors
- (2020) Jintong Du et al. Future Medicinal Chemistry
- Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers
- (2019) K. Louault et al. ONCOGENE
- Recent advances in the development of Mcl-1 inhibitors for cancer therapy
- (2019) Alexander W. Hird et al. PHARMACOLOGY & THERAPEUTICS
- Discovery of selective Mcl-1 inhibitors via structure-based design and structure-activity relationship analysis
- (2019) Nianzhe He et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors
- (2019) Chen Chen et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
- (2019) Taekyu Lee et al. JOURNAL OF MEDICINAL CHEMISTRY
- From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1 (MCL1)
- (2019) James William Papatzimas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Renieramycin T Induces Lung Cancer Cell Apoptosis by Targeting Mcl-1 Degradation: A New Insight in the Mechanism of Action
- (2019) Korrakod Petsri et al. Marine Drugs
- Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors
- (2019) Bruce Follows et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression
- (2019) Jianliang Xu et al. Cell Communication and Signaling
- Discovery of β-carboline copper(II) complexes as Mcl-1 inhibitor and in vitro and in vivo activity in cancer models
- (2019) Xing Lu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity
- (2019) Zoltan Szlávik et al. JOURNAL OF MEDICINAL CHEMISTRY
- MCL-1 inhibitors – where are we now (2019)?
- (2019) Steven Fletcher EXPERT OPINION ON THERAPEUTIC PATENTS
- Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands
- (2019) Ziqian Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Degradation of MCL-1 by bufalin reverses acquired resistance to osimertinib in EGFR-mutant lung cancer
- (2019) Fei Cao et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer
- (2019) Qiuyuan Wen et al. Diagnostic Pathology
- Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere
- (2019) Gwenaella Rescourio et al. JOURNAL OF MEDICINAL CHEMISTRY
- MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma
- (2019) Lesley Castillo et al. ONCOGENE
- Kröhnke pyridines: Rapid and facile access to Mcl-1 inhibitors
- (2018) Ivie L. Conlon et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of Mcl-1 inhibitors based on a thiazolidine-2,4-dione scaffold
- (2018) Ellis Whiting et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Recent encounters with atropisomerism in drug discovery
- (2018) Peter W. Glunz BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents
- (2018) Yichao Wan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A
- (2018) Alma Abou Samra et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design
- (2018) Subrata Shaw et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
- (2018) Nicholas A. Meanwell JOURNAL OF MEDICINAL CHEMISTRY
- Discovery and development of substituted tyrosine derivatives as Bcl-2/Mcl-1 inhibitors
- (2018) Renshuai Liu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening
- (2018) Ahmed S. A. Mady et al. Scientific Reports
- Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode
- (2018) Siham Hedir et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Reducing the Lipophilicity of Perfluoroalkyl Groups by CF2–F/CF2–Me or CF3/CH3 Exchange
- (2018) Benjamin Jeffries et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
- (2018) Adriana E. Tron et al. Nature Communications
- Recent insights into synthetic β -carbolines with anti-cancer activities
- (2017) Sumit Kumar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Looking Back, Looking Forward at Halogen Bonding in Drug Discovery
- (2017) Lois Mendez et al. MOLECULES
- Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors
- (2017) Jeffrey W. Johannes et al. ACS Medicinal Chemistry Letters
- FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism
- (2017) Li-Yuan Bai et al. Scientific Reports
- Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination
- (2016) Ting Song et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Fragment-Based Design, Synthesis, and Biological Evaluation of 1-Substituted-indole-2-carboxylic Acids as Selective Mcl-1 Inhibitors
- (2016) Ziqian Wang et al. ARCHIV DER PHARMAZIE
- Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites
- (2016) Mingping Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Structural Re-engineering of the α-Helix Mimetic JY-1-106 into Small Molecules: Disruption of the Mcl-1-Bak-BH3 Protein-Protein Interaction with 2,6-Di-Substituted Nicotinates
- (2016) Brandon Drennen et al. ChemMedChem
- A Phase II Study of AT-101 to Overcome Bcl-2–Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer
- (2016) Mark N. Stein et al. Clinical Genitourinary Cancer
- Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein
- (2016) Maryanna E. Lanning et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Mcl-1 inhibitors: a patent review
- (2016) Lijia Chen et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods
- (2016) Nicholas F. Pelz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules
- (2016) Jeremy L. Yap et al. JOURNAL OF MEDICINAL CHEMISTRY
- Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions
- (2016) Charlotte Gény et al. JOURNAL OF NATURAL PRODUCTS
- Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain
- (2016) Gizem Akçay et al. Nature Chemical Biology
- Allosteric inhibition of antiapoptotic MCL-1
- (2016) Susan Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure-based design of 3-carboxy-substituted 1,2,3,4-tetrahydroquinolines as inhibitors of myeloid cell leukemia-1 (Mcl-1)
- (2016) L. Chen et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapy
- (2016) Duong Nhu et al. MedChemComm
- Allosteric inhibition of antiapoptotic MCL-1
- (2016) Susan Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors
- (2015) Yichao Wan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors
- (2015) Yichao Wan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors
- (2015) Gang Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with erlotinib in patients with advanced solid tumors
- (2015) Anthony W. Tolcher et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- The BCL-2 protein family, BH3-mimetics and cancer therapy
- (2015) A R D Delbridge et al. CELL DEATH AND DIFFERENTIATION
- Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1
- (2015) Andrew M. Beekman et al. ChemMedChem
- Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors
- (2015) Rongshi Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-xL-Targeting Strategies
- (2015) Céline Gloaguen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design
- (2015) Jason P. Burke et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity
- (2015) Milan Bruncko et al. JOURNAL OF MEDICINAL CHEMISTRY
- A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia
- (2015) Thomas J. Kipps et al. LEUKEMIA & LYMPHOMA
- Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins
- (2015) Sandy Desrat et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Small molecule Mcl-1 inhibitors for the treatment of cancer
- (2015) Johannes Belmar et al. PHARMACOLOGY & THERAPEUTICS
- Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
- (2015) J D Leverson et al. Cell Death & Disease
- Design, synthesis and structure–activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2
- (2014) Xiangqian Li et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1
- (2014) Sandy Desrat et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein
- (2014) Andrew M. Petros et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins
- (2014) S. Desrat et al. CHEMICAL COMMUNICATIONS
- Development of 3-Phenyl-N-(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide Compounds as Inhibitors of Antiapoptotic Bcl-2 Family Proteins
- (2014) Chengwen Yang et al. ChemMedChem
- Conformational restriction: an effective tactic in 'follow-on'-based drug discovery
- (2014) Zengjun Fang et al. Future Medicinal Chemistry
- Endiandric Acid Analogues from Beilschmiedia ferruginea as Dual Inhibitors of Bcl-xL/Bak and Mcl-1/Bid Interactions
- (2014) Cécile Apel et al. JOURNAL OF NATURAL PRODUCTS
- Marinopyrrole Derivatives with Sulfide Spacers as Selective Disruptors of Mcl-1 Binding to Pro-Apoptotic Protein Bim
- (2014) Chunwei Cheng et al. Marine Drugs
- Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-xL Binding to Bim
- (2014) Chunwei Cheng et al. Marine Drugs
- Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)
- (2014) Chao Fang et al. ACS Medicinal Chemistry Letters
- Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein
- (2014) Barbara Mojsa et al. Cells
- Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker
- (2013) David J. Richard et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway
- (2013) M J Roy et al. BRITISH JOURNAL OF PHARMACOLOGY
- Advances in Copper Complexes as Anticancer Agents
- (2013) Carlo Santini et al. CHEMICAL REVIEWS
- Characterization of the Stereochemical Structures of 2H-Thiazolo[3,2-a]pyrimidine Compounds and Their Binding Affinities for Anti-apoptotic Bcl-2 Family Proteins
- (2013) Yaochun Xu et al. ChemMedChem
- De Novo Design, Synthesis and Evaluation of Benzylpiperazine Derivatives as Highly Selective Binders of Mcl-1
- (2013) Xiao Ding et al. ChemMedChem
- Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking
- (2013) Zhichao Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Lipophilic efficiency: the most important efficiency metric in medicinal chemistry
- (2013) Kevin D Freeman-Cook et al. Future Medicinal Chemistry
- Correction to 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) Based Molecules as Potent, Dual Inhibitors of B-Cell Lymphoma 2 (Bcl-2) and Myeloid Cell Leukemia Sequence 1 (Mcl-1): Structure-Based Design and Structure–Activity Relationship Studies
- (2013) Ting Song et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins
- (2013) Yuta Tanaka et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo
- (2013) F. Abulwerdi et al. MOLECULAR CANCER THERAPEUTICS
- 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1
- (2012) Ting Song et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival
- (2012) Nicole A. Cohen et al. CHEMISTRY & BIOLOGY
- Synthesis and biological activities of polyquinoline derivatives: New Bcl-2 family protein modulators
- (2012) Emmanuelle Saugues et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach
- (2012) Zhichao Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors
- (2012) Zhichao Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation
- (2012) Kenichiro Doi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Anthraquinone Scaffold for Putative, Two-Face Bim BH3 α-Helix Mimic
- (2012) Zhichao Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
- (2012) Anders Friberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors
- (2012) Jeremy L. Yap et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Thr 163 Phosphorylation Causes Mcl-1 Stabilization when Degradation Is Independent of the Adjacent GSK3-Targeted Phosphodegron, Promoting Drug Resistance in Cancer
- (2012) Shanna K. Nifoussi et al. PLoS One
- Pharmacological Properties of the Marine Natural Product Marinopyrrole A against Methicillin-Resistant Staphylococcus aureus
- (2011) Nina M. Haste et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: Characteristics of broad-spectrum protein binding and its effects on anti-tumor activity
- (2011) Can-Hui Zheng et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery and Development of Thiazolo[3,2-a]pyrimidinone Derivatives as General Inhibitors of Bcl-2 Family Proteins
- (2011) Bingcheng Zhou et al. ChemMedChem
- Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design
- (2011) Zhichao Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) Based Molecules as Potent, Dual Inhibitors of B-Cell Lymphoma 2 (Bcl-2) and Myeloid Cell Leukemia Sequence 1 (Mcl-1): Structure-Based Design and Structure−Activity Relationship Studies
- (2011) Zhichao Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
- (2011) Ingrid E. Wertz et al. NATURE
- Synthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1
- (2011) Paul H. Bernardo et al. PURE AND APPLIED CHEMISTRY
- An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins
- (2011) Jun Wei et al. Frontiers in Oncology
- Synthesis and biological activities of new di- and trimeric quinoline derivatives
- (2010) Sidonie Broch et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and in vitro antiproliferative activities of quinoline derivatives
- (2010) Sidonie Broch et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Mcl-1; the molecular regulation of protein function
- (2010) Luke W. Thomas et al. FEBS LETTERS
- A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1
- (2010) Zhichao Zhang et al. INTERNATIONAL JOURNAL OF CANCER
- Apoptotic Regulation by MCL-1 through Heterodimerization
- (2010) Qian Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner
- (2010) Aslamuzzaman Kazi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synthesis and Biological Evaluation of Apogossypolone Derivatives as Pan-active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins
- (2010) Jun Wei et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural Insights into the Design of Small Molecule Inhibitors That Selectively Antagonize Mcl-1
- (2010) Paul H. Bernardo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Interaction Study of Quinazoline-2(1H)-thione Derivatives as Novel Potential Bcl-xLInhibitors
- (2010) Yu Feng et al. JOURNAL OF MEDICINAL CHEMISTRY
- BI-97C1, an Optically Pure Apogossypol Derivative as Pan-Active Inhibitor of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins
- (2010) Jun Wei et al. JOURNAL OF MEDICINAL CHEMISTRY
- Gymnochromes E and F, Cytotoxic Phenanthroperylenequinones from a Deep-Water Crinoid,Holopus rangii
- (2010) Hilaire V. Kemami Wangun et al. JOURNAL OF NATURAL PRODUCTS
- Cryptosphaerolide, a Cytotoxic Mcl-1 Inhibitor from a Marine-Derived Ascomycete Related to the GenusCryptosphaeria
- (2010) Hyuncheol Oh et al. JOURNAL OF NATURAL PRODUCTS
- Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes
- (2010) Emiko Fire et al. PROTEIN SCIENCE
- Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia
- (2009) R. W. Stam et al. BLOOD
- Synthetic Inhibitors of Extended Helix-Protein Interactions Based on a Biphenyl 4,4′-Dicarboxamide Scaffold
- (2009) Johanna M. Rodriguez et al. CHEMBIOCHEM
- Antiapoptotic Effect of c-Jun N-terminal Kinase-1 through Mcl-1 Stabilization in TNF-Induced Hepatocyte Apoptosis
- (2009) Yuzo Kodama et al. GASTROENTEROLOGY
- Apogossypol Derivatives as Pan-Active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins
- (2009) Jun Wei et al. JOURNAL OF MEDICINAL CHEMISTRY
- NMR Strategy for Unraveling Structures of Bioactive Sponge-Derived Oxy-polyhalogenated Diphenyl Ethers⊥
- (2009) Laurent Calcul et al. JOURNAL OF NATURAL PRODUCTS
- Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis
- (2009) K. Boisvert-Adamo et al. MOLECULAR CANCER RESEARCH
- Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
- (2009) Martin Schwickart et al. NATURE
- RNA Silencing of Mcl-1 Enhances ABT-737-Mediated Apoptosis in Melanoma: Role for a Caspase-8-Dependent Pathway
- (2009) Angela M. Keuling et al. PLoS One
- The discovery of small molecule chemical probes of Bcl-XL and Mcl-1
- (2008) Michael Prakesch et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Inducing apoptosis and enhancing chemosensitivity to Gemcitabine via RNA interference targeting Mcl-1 gene in pancreatic carcinoma cell
- (2008) San-Hua Wei et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer
- (2008) Q. Ding et al. CANCER RESEARCH
- Mcl-1 is a potential therapeutic target in multiple types of cancer
- (2008) C. Akgul CELLULAR AND MOLECULAR LIFE SCIENCES
- Mechanism of Synergy of N-(4-Hydroxyphenyl)Retinamide and ABT-737 in Acute Lymphoblastic Leukemia Cell Lines: Mcl-1 Inactivation
- (2008) Min H. Kang et al. JNCI-Journal of the National Cancer Institute
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