Article
Integrative & Complementary Medicine
Laetitia M. Youmbi, Yves S. D. Makong, Armelle T. Mbaveng, Simplice B. Tankeo, Ghislain W. Fotso, Bruno L. Ndjakou, Jean D. Wansi, Veronique P. Beng, Norbert Sewald, Bonaventure T. Ngadjui, Thomas Efferth, Victor Kuete
Summary: This study aimed to identify the cytotoxic constituents of Brucea antidysenterica and demonstrate their mode of induction of apoptosis on cancer cell lines. The results showed that Brucea antidysenterica and its constituents have potential antiproliferative effects and can induce apoptosis through caspase activation, alteration of mitochondrial membrane potential, and increased reactive oxygen species levels.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Pharmacology & Pharmacy
Xiao-yan Wang, Xiao-xia Yang, Peng-fei Shang, Zong-xue Zheng, Xiu-li Guo
Summary: Glutamine, the most abundant amino acid in the body, plays a crucial role in nucleotide and non-essential amino acid synthesis during cell metabolism. Recent studies have shown that glutamine metabolic reprogramming serves as a significant signal in cancer development and progression. This metabolic signature in cancer cells can activate multiple signaling pathways and oncogenes, promoting cancer growth, tumor immune regulation, and drug resistance. This review summarizes the impact of glutamine metabolic reprogramming in tumors, focusing on the regulation of various signaling pathways. Additionally, potential tumor treatment strategies by targeting glutamine metabolism alone or in combination with chemotherapy are discussed.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Armelle T. Mbaveng, Cedric G. T. Noulala, Anne R. M. Samba, Simplice B. Tankeo, Ghislain W. Fotso, Emmanuel N. Happi, Bonaventure T. Ngadjui, Veronique P. Beng, Victor Kuete, Thomas Efferth
Summary: This study investigated the phytochemical constituents of Araliopsis soyauxii and found that extracts and compound 12 showed cytotoxicity against various cancer cell lines. The mechanisms of inducing apoptosis varied between ASB and compound 12, indicating their potential as sources of cytotoxic phytochemicals for further exploration in developing anticancer drugs.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Da-Yong Hou, Man-Di Wang, Xing-Jie Hu, Zhi-Jia Wang, Ni-Yuan Zhang, Gan-Tian Lv, Jia-Qi Wang, Xiu-Hai Wu, Lu Wang, Hao Wang, Wanhai Xu
Summary: Intraoperative fluorescence-based tumor imaging is important for safe tumor resection and differentiation of tumor from normal tissues. However, the application of fluorescence contrast agents in renal cell carcinoma and hepatocellular carcinoma is limited. In this study, an activated excretion-retarded tumor imaging strategy was developed, which could be activated in situ with MMP-2 and self-assembled on the tumor cell surface, leading to extended tumor retention time and enhanced imaging signal.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Tsvetelina Batsalova, Yordan Georgiev, Dzhemal Moten, Ivanka Teneva, Balik Dzhambazov
Summary: This study aimed to evaluate the cytotoxicity and inhibitory potential of commercially available xylooligosaccharides (XOS) derived from corn against tumor cells. It was found that XOS exhibited antioxidant activity and showed remarkable inhibitory effect on lysosomes. However, it also affected mitochondrial functionality. XOS treatment reduced the production of proinflammatory cytokines and had a tumor-cell-specific influence on the glutathione antioxidant system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tamas Pivarcsik, Vivien Posa, Hilda Kovacs, Nora May, Gabriella Spengler, Szonja P. Posa, Szilard Toth, Zeinab Nezafat Yazdi, Csilla Ozvegy-Laczka, Imre Ugrai, Istvan Szatmari, Gergely Szakacs, Eva A. Enyedy
Summary: This article investigates a novel 5-nitro-8-hydroxyquinoline-proline hybrid and its Rh(eta(5)-C5Me5) and Ru(eta(6)-p-cymene) complexes, which have excellent solubility in water and show inhibitory effects on sensitive and multidrug-resistant cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyuan Ji, Daoxia Guo, Jia Ma, Min Yin, Yun Yu, Chang Liu, Yanfeng Zhou, Jinli Sun, Qian Li, Nan Chen, Chunhai Fan, Haiyun Song
Summary: The hydrogel patch designed to modulate the plasticity of T-ICs in TNBC shows promising results in improving chemosensitivity, enhancing tumor immunogenicity, and increasing T-cell infiltration. Additionally, the patch efficiently suppresses tumor growth, postsurgical relapse, and metastasis with a single dose, demonstrating superior efficacy against multidrug resistance.
ADVANCED MATERIALS
(2021)
Article
Materials Science, Biomaterials
Jingwen Xu, Xiangji Yan, Xin Ge, Mingzhen Zhang, Xugang Dang, Yan Yang, Feng Xu, Yanling Luo, Guoliang Li
Summary: The research established a novel nanovehicle with multi-stimuli sensitive mechanism for on-demand release of anticancer drugs in acid and redox stress environment. By encapsulating drugs through physical and chemical methods, it effectively inhibited tumor growth.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biotechnology & Applied Microbiology
Xiangyang Zhang, Min Wang, Junyi Feng, Bin Qin, Chenglin Zhang, Chengshen Zhu, Wentao Liu, Yaohe Wang, Wei Liu, Lei Huang, Shuangshuang Lu, Zhimin Wang
Summary: The development of multidrug resistance (MDR) in cancer chemotherapy is a major challenge. This study identified MVP and BCL2 as potential factors driving MDR in ESCC. A self-assembling nanoparticle platform was designed to deliver Adriamycin and siRNAs targeting MVP and BCL2, reducing drug efflux and promoting apoptosis. The nanoparticles effectively inhibited cancer cell growth and tumor development.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Immunology
Vanessa Wiening, Tina Schmidt, Maximilian Dahmen, Sami Siam, Stefan Reuter, Hermann-Joseph Pavenstadt, Martina Sester, Barbara Suwelack
Summary: This case report successfully demonstrates a treatment strategy for multidrug-resistant cytomegalovirus after solid organ transplantation, using high-dose CMV-IVIG and conversion of immunosuppressive drugs to mTOR inhibitors and cyclosporine A rather than direct antiviral drugs. The treatment was associated with quantitative induction of CMV-specific T cells and showed decreasing viral load.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Pan Fu, Qiang Zhao, Li Shi, Qin Xiong, Zijing Ren, Hongxia Xu, Senmao Chai, Qianqian Xu, Xiaodong Sun, Ming Sang
Summary: This study isolated and characterized two new bacteriophages capable of infecting multidrug-resistant E. coli, demonstrating rapid replication, high stability, and no obvious cytotoxicity. These phages show potential as therapeutic candidates for treating multidrug-resistant E. coli in the future.
Article
Chemistry, Multidisciplinary
Okan Tezcan, Asmaa Said Elshafei, Karina Benderski, Elena Rama, Maike Wagner, Diana Moeckel, Robert Pola, Michal Pechar, Tomas Etrych, Saskia von Stillfried, Fabian Kiessling, Ralf Weiskirchen, Steffen Meurer, Twan Lammers
Summary: Multidrug resistance (MDR) reduces the efficacy of chemotherapy by inducing drug efflux pumps and altering the tumor microenvironment (TME) composition, limiting drug delivery. Multidrug-resistant tumors displayed a more mesenchymal phenotype, increased collagen production, enriched TME, and enhanced vascular perfusion. Drug carriers accumulated more efficiently in resistant tumors but had a limited ability to penetrate the interstitium. Microenvironmental drug resistance affected liposomal doxorubicin performance more than free doxorubicin.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
In-Geun Jung, Jae-Young Jeong, Seung-Hoon Yum, You-Jin Hwang
Summary: This study screened 16 medicinal plants and found that some extracts and fractions showed significant inhibitory effects on Staphylococcus aureus, including multidrug-resistant strains, with low cytotoxicity to human cells.
Article
Microbiology
Yeon Hee Ban, Myoung Chong Song, Joong Ho Jeong, Min Seok Kwun, Chang Rae Kim, Hwi So Ryu, Eunji Kim, Je Won Park, Dong Gun Lee, Yeo Joon Yoon
Summary: This study synthesized new aminoglycoside antibiotics enzymatically, with structural modifications enhancing their antibacterial activity against multidrug-resistant gram-negative bacteria while reducing nephrotoxicity.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Cell Biology
Nathalia Leal Santos, Silvina Odete Bustos, Darshak Bhatt, Roger Chammas, Luciana Nogueira de Sousa Andrade
Summary: Extracellular vesicles (EVs) play a crucial role in cancer progression by affecting continuous tumor growth, angiogenesis, metastasis, immune infiltrating cells, and treatment response. Understanding the mechanisms controlling EVs secretion and cargo sorting is essential to impede tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)