标题
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis
作者
关键词
cystine, cysteine, ferroptosis, GCLC, glutamate, γ-glutamyl, NRF2
出版物
Cell Metabolism
Volume 33, Issue 1, Pages 174-189.e7
出版商
Elsevier BV
发表日期
2020-12-23
DOI
10.1016/j.cmet.2020.12.007
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- γ-Glutamylcysteine synthetase and γ-glutamyl transferase as differential enzymatic sources of γ-glutamylpeptides in mice
- (2020) Sho Kobayashi et al. AMINO ACIDS
- Cysteine depletion induces pancreatic tumor ferroptosis in mice
- (2020) Michael A. Badgley et al. SCIENCE
- Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
- (2020) Mariluz Soula et al. Nature Chemical Biology
- The Complex Interplay between Antioxidants and ROS in Cancer
- (2020) Isaac S. Harris et al. TRENDS IN CELL BIOLOGY
- A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity
- (2019) Jennifer Yinuo Cao et al. Cell Reports
- Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
- (2019) Isaac S. Harris et al. Cell Metabolism
- Multiple pathways for the formation of the γ-glutamyl peptides γ-glutamyl-valine and γ- glutamyl-valyl-glycine in Saccharomyces cerevisiae
- (2019) Olga A. Sofyanovich et al. PLoS One
- Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
- (2019) Jonathan K. M. Lim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53
- (2019) Julia I-Ju Leu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer
- (2019) Yun Pyo Kang et al. eLife
- Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
- (2019) Pei-Hsuan Chen et al. MOLECULAR CELL
- FSP1 is a glutathione-independent ferroptosis suppressor
- (2019) Sebastian Doll et al. NATURE
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
- (2019) Kirill Bersuker et al. NATURE
- Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis
- (2018) Michael M. Gaschler et al. ACS Chemical Biology
- xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression
- (2018) Xiangming Ji et al. ONCOGENE
- Role of Mitochondria in Ferroptosis
- (2018) Minghui Gao et al. MOLECULAR CELL
- Lipoic acid metabolism and mitochondrial redox regulation
- (2017) Ashley Solmonson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
- (2017) Samantha W. Alvarez et al. NATURE
- Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses
- (2017) L Torrente et al. ONCOGENE
- Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma
- (2017) Gregory S. Ducker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
- (2017) Chun-Shik Shin et al. Nature Communications
- Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine
- (2017) Ioannis Poursaitidis et al. Cell Reports
- Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
- (2017) Volkan I Sayin et al. eLife
- Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
- (2017) Z Fan et al. Oncogenesis
- Mitochondria and Cancer
- (2016) Sejal Vyas et al. CELL
- Mechanisms of ferroptosis
- (2016) Jennifer Yinuo Cao et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery
- (2016) Thomas G. Davies et al. JOURNAL OF MEDICINAL CHEMISTRY
- TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions
- (2016) Inmaculada Martínez-Reyes et al. MOLECULAR CELL
- ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
- (2016) Sebastian Doll et al. Nature Chemical Biology
- Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
- (2016) Shira L Cramer et al. NATURE MEDICINE
- Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
- (2015) Scott J. Dixon et al. ACS Chemical Biology
- Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression
- (2015) Isaac S. Harris et al. CANCER CELL
- Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- (2015) Xiaofang Sun et al. HEPATOLOGY
- Glutaminolysis and Transferrin Regulate Ferroptosis
- (2015) Minghui Gao et al. MOLECULAR CELL
- Ferroptosis as a p53-mediated activity during tumour suppression
- (2015) Le Jiang et al. NATURE
- NRF2 regulates serine biosynthesis in non–small cell lung cancer
- (2015) Gina M DeNicola et al. NATURE GENETICS
- TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation
- (2015) Hannah Greenfeld et al. PLoS Pathogens
- Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress
- (2015) Eric Habib et al. Redox Biology
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
- (2014) Joseph D. Mancias et al. NATURE
- Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
- (2013) Luika A. Timmerman et al. CANCER CELL
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease
- (2012) T. A. Rouault Disease Models & Mechanisms
- Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas
- (2012) Satoru Takeuchi et al. NEUROSURGERY
- Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease
- (2011) Tomoyoshi Soga et al. JOURNAL OF HEPATOLOGY
- Hereditary Sensory Neuropathy Type 1 Is Caused by the Accumulation of Two Neurotoxic Sphingolipids
- (2010) Anke Penno et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
- (2009) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels
- (2008) M. H. Stipanuk et al. AMINO ACIDS
- Thiol chemistry and specificity in redox signaling
- (2008) Christine C. Winterbourn et al. FREE RADICAL BIOLOGY AND MEDICINE
- Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach
- (2008) Bryson D Bennett et al. Nature Protocols
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