The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses

Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection

(2020) Tania Løve Aaes et al.   JOURNAL OF IMMUNOLOGY

Prediction of cancer neoepitopes needs new rules

(2020) Cory A. Brennick et al.   SEMINARS IN IMMUNOLOGY

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

The clearance of dead cells by efferocytosis

(2020) Emilio Boada-Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

(2020) Lorenzo Galluzzi et al.   Journal for ImmunoTherapy of Cancer

A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer

(2019) Lucia D’Amico et al.   Journal for ImmunoTherapy of Cancer

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

Mechanisms of natural killer cell‐mediated cellular cytotoxicity

(2019) Isabel Prager et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immunogenic cell death in cancer therapy: Present and emerging inducers

(2019) Jingyi Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cancer Immunotherapies and Humanized Mouse Drug Testing Platforms

(2019) Qingfeng Chen et al.   Translational Oncology

An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses

(2019) Ismail M. Meraz et al.   Cancer Immunology Research

Intratumorally delivered formulation, INT230-6, containing potent anticancer agents induces protective T cell immunity and memory

(2019) Anja C. Bloom et al.   OncoImmunology

Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer

(2019) Dennis Wang et al.   Cancers

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity

(2019) Annelise G. Snyder et al.   Science Immunology

RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity

(2019) Susana L. Orozco et al.   Cell Reports

The Diversification of Cell Death and Immunity: Memento Mori

(2019) Arnaud J. Legrand et al.   MOLECULAR CELL

Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine

(2019) Victoria D. Turubanova et al.   Journal for ImmunoTherapy of Cancer

Small Particles, Big Effects: The Interplay Between Exosomes and Dendritic Cells in Antitumor Immunity and Immunotherapy

(2019) Bruno Deltreggia Benites et al.   Cells

Immunogenic Apoptosis as a Novel Tool for Anticancer Vaccine Development

(2018) Barbara Montico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

(2018) Mirjana Efremova et al.   Nature Communications

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

(2018) Lien Van Hoecke et al.   Nature Communications

Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment

(2017) James L. Gulley et al.   JNCI-Journal of the National Cancer Institute

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

(2017) Vinod P. Balachandran et al.   NATURE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

(2017) Diego Chowell et al.   SCIENCE

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

(2017) Janet Lau et al.   Nature Communications

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

(2017) Pornpimol Charoentong et al.   Cell Reports

Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment

(2017) James L. Gulley et al.   JNCI-Journal of the National Cancer Institute

Tumor-Derived Microvesicles Modulate Antigen Cross-Processing via Reactive Oxygen Species-Mediated Alkalinization of Phagosomal Compartment in Dendritic Cells

(2017) Federico Battisti et al.   Frontiers in Immunology

Immunogenicity of Allo-Vesicle Carrying ERBB2 Tumor Antigen for Dendritic Cell-Based Anti-Tumor Immunotherapy

(2017) C. Napoletano et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Monitoring immune responses in the tumor microenvironment

(2016) Jennifer A Wargo et al.   CURRENT OPINION IN IMMUNOLOGY

Genetically engineered mouse models in oncology research and cancer medicine

(2016) Kelly Kersten et al.   EMBO Molecular Medicine

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

Cancer/Testis Antigens: Expression, Regulation, Tumor Invasion, and Use in Immunotherapy of Cancers

(2016) Arash Salmaninejad et al.   IMMUNOLOGICAL INVESTIGATIONS

Antigen processing and immune regulation in the response to tumours

(2016) Emma Reeves et al.   IMMUNOLOGY

Cancer immunotherapy targeting neoantigens

(2016) Yong-Chen Lu et al.   SEMINARS IN IMMUNOLOGY

Dendritic Cells and Cancer Immunity

(2016) Alycia Gardner et al.   TRENDS IN IMMUNOLOGY

Combination of radiotherapy and vaccination overcomes checkpoint blockade resistance

(2016) Wenxin Zheng et al.   Oncotarget

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

(2016) Tania Løve Aaes et al.   Cell Reports

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

(2016) Heng Yang et al.   OncoImmunology

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

(2015) Michael S. Rooney et al.   CELL

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

The MAGE protein family and cancer

(2015) Jenny L Weon et al.   CURRENT OPINION IN CELL BIOLOGY

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

(2015) Tien-Jen Lin et al.   Molecular Cancer

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

(2015) Sebastian Kreiter et al.   NATURE

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1α release, and efficient paracrine dendritic cell activation

(2015) Susanne V. Schmidt et al.   Oncotarget

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer

(2015) Jitka Fucikova et al.   Frontiers in Immunology

Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma

(2014) John C Castle et al.   BMC GENOMICS

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis

(2014) S Orozco et al.   CELL DEATH AND DIFFERENTIATION

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

Cell-free Tumor Microparticle Vaccines Stimulate Dendritic Cells via cGAS/STING Signaling

(2014) H. Zhang et al.   Cancer Immunology Research

Murine leukemia virus envelope gp70 is a shared biomarker for the high-sensitivity quantification of murine tumor burden

(2014) Francesca Scrimieri et al.   OncoImmunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy

(2013) Matthew D. Vesely et al.   Annals of the New York Academy of Sciences

Mammaglobin B (SCGB2A1) is a novel tumour antigen highly differentially expressed in all major histological types of ovarian cancer: implications for ovarian cancer immunotherapy

(2013) S Bellone et al.   BRITISH JOURNAL OF CANCER

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

(2013) J. Duraiswamy et al.   CANCER RESEARCH

Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists

(2013) T Yamazaki et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response

(2013) Michel DuPage et al.   CURRENT OPINION IN IMMUNOLOGY

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Immunogenicity of Murine Solid Tumor Models as a Defining Feature of In Vivo Behavior and Response to Immunotherapy

(2013) Melissa G. Lechner et al.   JOURNAL OF IMMUNOTHERAPY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Many faces of DAMPs in cancer therapy

(2013) O Krysko et al.   Cell Death & Disease

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Augmenting Antitumor T-Cell Responses to Mimotope Vaccination by Boosting with Native Tumor Antigens

(2012) J. D. Buhrman et al.   CANCER RESEARCH

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

Expression of tumour-specific antigens underlies cancer immunoediting

(2012) Michel DuPage et al.   NATURE

Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

(2012) Mickaël Michaud et al.   OncoImmunology

Elevated Tumor-Associated Antigen Expression Suppresses Variant Peptide Vaccine Responses

(2011) C. B. Kemmler et al.   JOURNAL OF IMMUNOLOGY

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Direct identification of an HPV-16 tumor antigen from cervical cancer biopsy specimens

(2011) Derin Derin B   Frontiers in Immunology

Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress

(2010) I Martins et al.   ONCOGENE

Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens

(2010) K. R. Jordan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization of survivin-derived H-2Kb-restricted CTL epitopes

(2009) Uta B. Hofmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Induction of Tumor Cell Apoptosis or Necrosis by Conditional Expression of Cell Death Proteins: Analysis of Cell Death Pathways and In Vitro Immune Stimulatory Potential

(2009) C. Lohmann et al.   JOURNAL OF IMMUNOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses

(2008) I. S. Zeelenberg et al.   CANCER RESEARCH

Age-dependent tolerance to an endogenous tumor-associated antigen

(2008) Jennifer A. McWilliams et al.   VACCINE