标题
Triple-negative breast cancer therapeutic resistance: Where is the Achilles' heel?
作者
关键词
TNBC, Therapeutic resistance, DNA repair, Tumor microenvironment, Clinical trial, Targeted drug, Immunotherapy
出版物
CANCER LETTERS
Volume 497, Issue -, Pages 100-111
出版商
Elsevier BV
发表日期
2020-10-16
DOI
10.1016/j.canlet.2020.10.016
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Immunosuppressive Microenvironment in BRCA1-IRIS–Overexpressing TNBC Tumors Is Induced by Bidirectional Interaction with Tumor-Associated Macrophages
- (2020) Eman Sami et al. CANCER RESEARCH
- Inhibition of FEN1 Increases Arsenic Trioxide-Induced ROS Accumulation and Cell Death: Novel Therapeutic Potential for Triple Negative Breast Cancer
- (2020) Xing Xin et al. Frontiers in Oncology
- PD-L1 and CD8 are associated with deficient mismatch repair status in triple-negative and HER2-positive breast cancers
- (2019) Yanjun Hou et al. HUMAN PATHOLOGY
- Tumor mutational load predicts survival after immunotherapy across multiple cancer types
- (2019) Robert M. Samstein et al. NATURE GENETICS
- Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis
- (2019) Meixi Peng et al. Cell Death & Disease
- Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
- (2019) Dongya Jia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1
- (2019) Cecilia Roux et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer
- (2019) Aditya Bardia et al. NEW ENGLAND JOURNAL OF MEDICINE
- Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy
- (2019) Jun Wang et al. NATURE MEDICINE
- FDA Approval Summary: Pembrolizumab for the treatment of microsatellite instability-high solid tumors
- (2019) Leigh Marcus et al. CLINICAL CANCER RESEARCH
- Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies
- (2019) Yi-Zhou Jiang et al. CANCER CELL
- Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes
- (2019) Maarten van Eijk et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy
- (2019) Amira A. Barkal et al. NATURE
- Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment
- (2019) Fabiola Lilí Sarmiento-Salinas et al. Frontiers in Oncology
- Cisplatin-resistant MDA-MB-231 cell-derived exosomes increase the resistance of recipient cells in an exosomal miR-423-5p-dependent manner
- (2019) Bing Wang et al. CURRENT DRUG METABOLISM
- Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study
- (2019) Johan Staaf et al. NATURE MEDICINE
- ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts
- (2019) Jin Sol Sung et al. ONCOGENE
- EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming
- (2019) Fanyan Meng et al. Nature Communications
- TBCRC 032 IB/II Multicenter Study: Molecular insights to AR antagonist and PI3K inhibitor efficacy in patients with AR+ metastatic triple-negative breast cancer
- (2019) Brian D. Lehmann et al. CLINICAL CANCER RESEARCH
- Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
- (2019) Sijia Liu et al. CLINICAL CANCER RESEARCH
- Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial
- (2019) Peter Schmid et al. JOURNAL OF CLINICAL ONCOLOGY
- The Relationship Between Mismatch Repair Deficiency and PD-L1 Expression in Breast Carcinoma
- (2018) Anne M. Mills et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
- (2018) Ana Costa et al. CANCER CELL
- Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the α-Ketoglutarate Signaling Pathway
- (2018) Chien-Wei Tseng et al. CANCER RESEARCH
- Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF-1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment
- (2018) Haiquan Lu et al. CANCER RESEARCH
- Cancer stem cell in breast cancer therapeutic resistance
- (2018) Xupeng Bai et al. CANCER TREATMENT REVIEWS
- JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance
- (2018) Tianyi Wang et al. Cell Metabolism
- Enzalutamide for the Treatment of Androgen Receptor–Expressing Triple-Negative Breast Cancer
- (2018) Tiffany A. Traina et al. JOURNAL OF CLINICAL ONCOLOGY
- Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial
- (2018) Andrew Tutt et al. NATURE MEDICINE
- Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide
- (2018) Lu Lu et al. ONCOGENE
- Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A
- (2018) Kyoko Hashimoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemotherapy induces enrichment of CD47+/CD73+/PDL1+immune evasive triple-negative breast cancer cells
- (2018) Debangshu Samanta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
- (2018) Aurélie S. Cazet et al. Nature Communications
- Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial
- (2018) Ines Stevic et al. BMC Medicine
- Paclitaxel With Inhibitor of Apoptosis Antagonist, LCL161, for Localized Triple-Negative Breast Cancer, Prospectively Stratified by Gene Signature in a Biomarker-Driven Neoadjuvant Trial
- (2018) Aditya Bardia et al. JOURNAL OF CLINICAL ONCOLOGY
- ATR inhibition is a promising radiosensitizing strategy for triple negative breast cancer
- (2018) Xinyi Tu et al. MOLECULAR CANCER THERAPEUTICS
- Survival analysis of carboplatin added to an anthracycline/taxane-based neoadjuvant chemotherapy and HRD score as predictor of response—final results from GeparSixto
- (2018) S Loibl et al. ANNALS OF ONCOLOGY
- Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer
- (2018) Peter Schmid et al. NEW ENGLAND JOURNAL OF MEDICINE
- Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance
- (2018) Gaofeng Xiong et al. Nature Communications
- Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
- (2017) Sung-Bae Kim et al. LANCET ONCOLOGY
- Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer
- (2017) Alexander Beatty et al. MOLECULAR CANCER THERAPEUTICS
- Senescence-associated reprogramming promotes cancer stemness
- (2017) Maja Milanovic et al. NATURE
- Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer
- (2016) Ashley M. Brinkman et al. BIOMATERIALS
- EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape
- (2016) S.-O. Lim et al. CANCER RESEARCH
- Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
- (2016) Wilhem Leconet et al. CLINICAL CANCER RESEARCH
- Immunization against HIF-1α Inhibits the Growth of Basal Mammary Tumors and Targets Mammary Stem CellsIn Vivo
- (2016) Denise L. Cecil et al. CLINICAL CANCER RESEARCH
- Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer
- (2016) Youyou Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Angiogenesis and Antiangiogenesis in Triple-Negative Breast cancer
- (2016) Domenico Ribatti et al. Translational Oncology
- Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer
- (2016) Youyou Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer
- (2015) Fanny Dupuy et al. Cell Metabolism
- Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis
- (2015) Miranda Y. Fong et al. NATURE CELL BIOLOGY
- Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
- (2015) Haiquan Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy
- (2015) W. Peng et al. Cancer Discovery
- Higher locoregional recurrence rate for triple-negative breast cancer following neoadjuvant chemotherapy, surgery and radiotherapy
- (2015) Chi Zhang et al. SpringerPlus
- Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers
- (2014) Sylvain Lefort et al. Autophagy
- Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis
- (2014) Weiying Zhou et al. CANCER CELL
- Prevalence and Clinicopathologic Correlates of O6-Methylguanine-DNA Methyltransferase Methylation Status in Patients With Triple-Negative Breast Cancer Treated Preoperatively by Alkylating Drugs
- (2014) Caterina Fumagalli et al. Clinical Breast Cancer
- Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer
- (2014) Ramesh Singh et al. Molecular Cancer
- Twist1 expression induced by sunitinib accelerates tumor cell vasculogenic mimicry by increasing the population of CD133+ cells in triple-negative breast cancer
- (2014) Danfang Zhang et al. Molecular Cancer
- Nanodiamond–Mitoxantrone Complexes Enhance Drug Retention in Chemoresistant Breast Cancer Cells
- (2014) Tan-Boon Toh et al. MOLECULAR PHARMACEUTICS
- XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
- (2014) Xi Chen et al. NATURE
- Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
- (2014) T. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
- (2014) P. Chaturvedi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prevalence of BRCA Mutations Among Women with Triple-Negative Breast Cancer (TNBC) in a Genetic Counseling Cohort
- (2013) Rachel Greenup et al. ANNALS OF SURGICAL ONCOLOGY
- Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma
- (2013) Xiang H.-F. Zhang et al. CELL
- Phase II Trial of Bicalutamide in Patients with Androgen Receptor-Positive, Estrogen Receptor-Negative Metastatic Breast Cancer
- (2013) A. Gucalp et al. CLINICAL CANCER RESEARCH
- ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas
- (2013) Sharon E. Johnatty et al. GYNECOLOGIC ONCOLOGY
- TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
- (2013) Neil E. Bhola et al. JOURNAL OF CLINICAL INVESTIGATION
- Prognostic and Predictive Value of Tumor-Infiltrating Lymphocytes in a Phase III Randomized Adjuvant Breast Cancer Trial in Node-Positive Breast Cancer Comparing the Addition of Docetaxel to Doxorubicin With Doxorubicin-Based Chemotherapy: BIG 02-98
- (2013) Sherene Loi et al. JOURNAL OF CLINICAL ONCOLOGY
- Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets
- (2013) J. M. Balko et al. Cancer Discovery
- DNA Mismatch Repair Deficiency in Breast Carcinoma
- (2012) Yong H. Wen et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers
- (2012) Mattia Poletto et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Loss of O6-methylguanine-DNA methyltransferase confers collateral sensitivity to carmustine in topoisomerase II-mediated doxorubicin resistant triple negative breast cancer cells
- (2012) Selina Raguz et al. BIOCHEMICAL PHARMACOLOGY
- An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer
- (2012) M. L. McCleland et al. CANCER RESEARCH
- Targeting MDR in breast and lung cancer: Discriminating its potential importance from the failure of drug resistance reversal studies
- (2012) Laleh Amiri-Kordestani et al. DRUG RESISTANCE UPDATES
- PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition
- (2012) Yasir H. Ibrahim et al. Cancer Discovery
- Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
- (2011) Brian D. Lehmann et al. JOURNAL OF CLINICAL INVESTIGATION
- Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
- (2011) Ingrid E. Wertz et al. NATURE
- Mesenchymal Stem Cells Protect Breast Cancer Cells through Regulatory T Cells: Role of Mesenchymal Stem Cell-Derived TGF-
- (2010) S. A. Patel et al. JOURNAL OF IMMUNOLOGY
- Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
- (2010) C. E. Strom et al. NUCLEIC ACIDS RESEARCH
- Significantly higher levels of vascular endothelial growth factor (VEGF) and shorter survival times for patients with primary operable triple-negative breast cancer
- (2009) B. K. Linderholm et al. ANNALS OF ONCOLOGY
- Triple-negative breast cancer--current status and future directions
- (2009) O. Gluz et al. ANNALS OF ONCOLOGY
- Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells
- (2008) P. J. Mishra et al. CANCER RESEARCH
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
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