Design, synthesis and antimycobacterial evaluation of novel adamantane and adamantanol analogues effective against drug-resistant tuberculosis

Kinase Targets for Mycolic Acid Biosynthesis in Mycobacterium tuberculosis

(2019) Shahinda S.R. Alsayed et al.   Current Molecular Pharmacology

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds

(2019) Wei Li et al.   ACS Infectious Diseases

Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target

(2019) Bing Zhang et al.   CELL

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

(2018) Hamish S. Sutherland et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Drug discovery in tuberculosis. New drug targets and antimycobacterial agents

(2018) André Campaniço et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections

(2017) Alan P. Kozikowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

MmpL3 is the flippase for mycolic acids in mycobacteria

(2017) Zhujun Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression

(2017) Giulia Degiacomi et al.   Scientific Reports

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

(2016) Wei Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Kinetic solubility and lipophilicity evaluation connecting formulation technology strategy perspective

(2016) Katsuhiko Yamamoto et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection

(2016) Jozef Stec et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tuberculosis

(2016) Keertan Dheda et al.   LANCET

Mycolic acids: deciphering and targeting the Achilles' heel of the tubercle bacillus

(2015) Vijayashankar Nataraj et al.   MOLECULAR MICROBIOLOGY

Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis

(2014) Wei Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis

(2014) C.J. Cambier et al.   CELL

Totally drug-resistant tuberculosis and adjunct therapies

(2014) S. K. Parida et al.   JOURNAL OF INTERNAL MEDICINE

Bedaquiline: A Novel Antitubercular Agent for the Treatment of Multidrug-Resistant Tuberculosis

(2014) Marylee V. Worley et al.   PHARMACOTHERAPY

The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

(2013) Lukas Wanka et al.   CHEMICAL REVIEWS

Insights on how theMycobacterium tuberculosisheme uptake pathway can be used as a drug target

(2013) Cedric P Owens et al.   Future Medicinal Chemistry

TheMycobacterium tuberculosisSecreted Protein Rv0203 Transfers Heme to Membrane Proteins MmpL3 and MmpL11

(2013) Cedric P. Owens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preliminary Structure–Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

(2013) Oluseye K. Onajole et al.   JOURNAL OF MEDICINAL CHEMISTRY

Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

(2013) S. P. S. Rao et al.   Science Translational Medicine

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

(2013) Shichun Lun et al.   Nature Communications

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability

(2012) Michael S. Scherman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mycobacterium tuberculosis Inhibits Neutrophil Apoptosis, Leading to Delayed Activation of Naive CD4 T cells

(2012) Robert Blomgran et al.   Cell Host & Microbe

MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria

(2012) Cristian Varela et al.   CHEMISTRY & BIOLOGY

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

(2012) Anna E Grzegorzewicz et al.   Nature Chemical Biology

Tuberculosis, Drug Resistance, and the History of Modern Medicine

(2012) Salmaan Keshavjee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unprecedented “In Water” Imidazole Carbonylation: Paradigm Shift for Preparation of Urea and Carbamate

(2012) Kamlesh J. Padiya et al.   ORGANIC LETTERS

Tuberculosis and HIV Co-Infection

(2012) Andrzej Pawlowski et al.   PLoS Pathogens

The structure–activity relationship of urea derivatives as anti-tuberculosis agents

(2011) Joshua R. Brown et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pyrido[1,2-a]benzimidazole-Based Agents Active Against Tuberculosis (TB), Multidrug-Resistant (MDR) TB and Extensively Drug-Resistant (XDR) TB

(2011) Marco Pieroni et al.   ChemMedChem

Discovery and characterization of a unique mycobacterial heme acquisition system

(2011) M. V. Tullius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

(2010) José A Caminero et al.   LANCET INFECTIOUS DISEASES

Comprehensive Treatment of Extensively Drug-Resistant Tuberculosis

(2008) Carole D. Mitnick et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disclosure of the mycobacterial outer membrane: Cryo-electron tomography and vitreous sections reveal the lipid bilayer structure

(2008) C. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA