Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

(2013) Lluís Ballell et al.   ChemMedChem

Time-Dependent Inhibition and Induction of Human Cytochrome P4503A4/5 by an Oral IAP Antagonist, LCL161, In Vitro and In Vivo in Healthy Subjects

(2013) Shyeilla Dhuria et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Preliminary Structure–Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

(2013) Oluseye K. Onajole et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides: A Promising Class of Antituberculosis Agents

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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Advances in the development of new tuberculosis drugs and treatment regimens

(2013) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

(2013) Modesto J. Remuiñán et al.   PLoS One

Approval of Novel TB Drug Celebrated--With Restraint

(2013) J. Cohen   SCIENCE

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria

(2012) Cristian Varela et al.   CHEMISTRY & BIOLOGY

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

(2012) Katherine A Sacksteder et al.   Future Microbiology

New Drugs for the Treatment of Tuberculosis: Needs, Challenges, Promise, and Prospects for the Future

(2012) Christian Lienhardt et al.   JOURNAL OF INFECTIOUS DISEASES

14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial

(2012) Andreas H Diacon et al.   LANCET

Transporter targeted in tuberculosis

(2012) Stewart T Cole   Nature Chemical Biology

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

(2012) Anna E Grzegorzewicz et al.   Nature Chemical Biology

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

(2011) Valentina La Rosa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development

(2011) David O. Nettleton et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Selection of oral bioavailability enhancing formulations during drug discovery

(2011) Weijia Zheng et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Challenges and opportunities in developing novel drugs for TB

(2011) Takushi Kaneko et al.   Future Medicinal Chemistry

Discovery and characterization of a unique mycobacterial heme acquisition system

(2011) M. V. Tullius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac Ion Channel Safety Profiling on the IonWorks Quattro Automated Patch Clamp System

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Optimisation of Bioluminescent Reporters for Use with Mycobacteria

(2010) Nuria Andreu et al.   PLoS One

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

(2010) Kevin Pethe et al.   Nature Communications

Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

(2009) Natilie A. Hosea et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE

Artificial Membrane Assays to Assess Permeability

(2008) Bernard Faller   CURRENT DRUG METABOLISM

Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug

(2004) Lee Jia et al.   BRITISH JOURNAL OF PHARMACOLOGY