Mechanistic insights into KDM4A driven genomic instability

Targeting the USP1 dependent KDM4A protein stability as a potential prostate cancer therapy

(2020) Shu‐Zhong Cui et al.   CANCER SCIENCE

Advances in histone demethylase KDM4 as cancer therapeutic targets

(2020) Dong Hoon Lee et al.   FASEB JOURNAL

SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

(2020) Huairui Yuan et al.   CANCER CELL

Upregulation of JMJD2A promotes migration and invasion in bladder cancer through regulation of SLUG

(2019) Fengyi Wang et al.   ONCOLOGY REPORTS

Recent insights into apoptosis and toxic autophagy: the roles of MDA-7/IL-24, a multidimensional anti-cancer therapeutic

(2019) Luni Emdad et al.   SEMINARS IN CANCER BIOLOGY

Formate metabolism in health and disease

(2019) Matthias Pietzke et al.   Molecular Metabolism

Engaging chromatin: PRC2 structure meets function

(2019) Paul Chammas et al.   BRITISH JOURNAL OF CANCER

High-Throughput Quantitative Top-Down Proteomics: Histone H4

(2019) Matthew V. Holt et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Histone Lysine Methylation Dynamics Control EGFR DNA Copy Number Amplification

(2019) Thomas L Clarke et al.   Cancer Discovery

Small molecule KDM4s inhibitors as anti-cancer agents

(2018) Hongzhi Lin et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance

(2018) Tao Wang et al.   Epigenetics & Chromatin

The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity

(2018) May Levin et al.   Oncotarget

CTCF-KDM4A complex correlates with histone modifications that negatively regulate CHD5 gene expression in cancer cell lines

(2018) Lissania Guerra-Calderas et al.   Oncotarget

Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications

(2018) Sweta Mishra et al.   CELL

Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26

(2018) Louise J. Walport et al.   FEBS LETTERS

Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies

(2018) Rohan N. Shah et al.   MOLECULAR CELL

Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A

(2018) Aniek Janssen et al.   GENES & DEVELOPMENT

A nucleosome-free region locally abrogates histone H1–dependent restriction of linker DNA accessibility in chromatin

(2018) Laxmi Narayan Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MiR-10a functions as a tumor suppressor in prostate cancer via targeting KDM4A

(2018) Haiqi Mu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models

(2017) Young K. Chen et al.   ACS Medicinal Chemistry Letters

H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1

(2017) Renata Z. Jurkowska et al.   Nature Communications

SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication

(2017) Wan-Shan Yang et al.   PLoS Pathogens

Dual Chromatin and Cytoskeletal Remodeling by SETD2

(2016) In Young Park et al.   CELL

Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy

(2016) Junjian Wang et al.   CELL DEATH AND DIFFERENTIATION

Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self‐renewal and early development

(2016) Marianne Terndrup Pedersen et al.   EMBO JOURNAL

Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway

(2016) Jianwei Zhang et al.   EXPERIMENTAL CELL RESEARCH

Regulation of Transient Site-specific Copy Gain by MicroRNA

(2016) Joshua C. Black et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of KDM4A Suppresses the Survival of Glioma Cells by Promoting Autophagy

(2016) Bo Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Structural basis for activity regulation of MLL family methyltransferases

(2016) Yanjing Li et al.   NATURE

Reader domain specificity and lysine demethylase-4 family function

(2016) Zhangli Su et al.   Nature Communications

Acetylation Mimics Within a Single Nucleosome Alter Local DNA Accessibility In Compacted Nucleosome Arrays

(2016) Laxmi N. Mishra et al.   Scientific Reports

KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis

(2016) Ling-Yu Wang et al.   Cell Reports

Too little O2Too much gain

(2015) Joshua C Black et al.   CELL CYCLE

Emerging roles of lysine methylation on non-histone proteins

(2015) Xi Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rph1/KDM4 Mediates Nutrient-Limitation Signaling that Leads to the Transcriptional Induction of Autophagy

(2015) Amélie Bernard et al.   CURRENT BIOLOGY

Advances in the development of histone lysine demethylase inhibitors

(2015) Tamara Maes et al.   CURRENT OPINION IN PHARMACOLOGY

Hypoxia drives transient site-specific copy gain and drug-resistant gene expression

(2015) Joshua C. Black et al.   GENES & DEVELOPMENT

Jumonji domain containing 2A predicts prognosis and regulates cell growth in lung cancer depending on miR-150

(2015) WEIHUA XU et al.   ONCOLOGY REPORTS

Targeting histone lysine methylation in cancer

(2015) John McGrath et al.   PHARMACOLOGY & THERAPEUTICS

Lysine Demethylase KDM4A Associates with Translation Machinery and Regulates Protein Synthesis

(2015) C. Van Rechem et al.   Cancer Discovery

Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway

(2015) S. W. Awwad et al.   Biology Open

JMJD2A predicts prognosis and regulates cell growth in human gastric cancer

(2014) Cheng-En Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interpreting the language of histone and DNA modifications

(2014) Scott B. Rothbart et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1

(2014) Rachel Schiller et al.   ChemMedChem

The Demethylase JMJD2C Localizes to H3K4me3-Positive Transcription Start Sites and Is Dispensable for Embryonic Development

(2014) M. T. Pedersen et al.   MOLECULAR AND CELLULAR BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

(2014) Sophia X. Pfister et al.   Cell Reports

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

(2013) Feng Li et al.   CELL

KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors

(2013) Joshua C. Black et al.   CELL

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

H3K56me3 Is a Novel, Conserved Heterochromatic Mark That Largely but Not Completely Overlaps with H3K9me3 in Both Regulation and Localization

(2013) Antonia P. M. Jack et al.   PLoS One

Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis

(2013) X. Ding et al.   Science Signaling

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

(2013) Richard J. Hopkinson et al.   Chemical Science

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

(2013) Lei Wang et al.   Nature Communications

Set2 mediated H3 lysine 36 methylation: regulation of transcription elongation and implications in organismal development

(2013) Swaminathan Venkatesh et al.   Wiley Interdisciplinary Reviews-Developmental Biology

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

Oncogenic features of the JMJD2A histone demethylase in breast cancer

(2012) WILLIAM L. BERRY et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Understanding the language of Lys36 methylation at histone H3

(2012) Eric J. Wagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases

(2012) Swathi Krishnan et al.   STRUCTURE

JMJD2A Promotes Cellular Transformation by Blocking Cellular Senescence through Transcriptional Repression of the Tumor Suppressor CHD5

(2012) Frédérick A. Mallette et al.   Cell Reports

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

(2011) Lars Hillringhaus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SKP1-Cul1-F-box and Leucine-rich Repeat Protein 4 (SCF-FbxL4) Ubiquitin Ligase Regulates Lysine Demethylase 4A (KDM4A)/Jumonji Domain-containing 2A (JMJD2A) Protein

(2011) Capucine Van Rechem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells

(2011) Tae-Dong Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

SCFFBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation

(2011) M.-K. M. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

Systems-wide proteomic characterization of combinatorial post-translational modification patterns

(2010) Nicolas L Young et al.   Expert Review of Proteomics

Structural Characterization of Formaldehyde-Induced Cross-Links Between Amino Acids and Deoxynucleosides and Their Oligomers

(2010) Kun Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown

(2010) Mariana D. Plazas-Mayorca et al.   Molecular BioSystems

Histone Demethylation and Timely DNA Replication

(2010) Erica L. Gerace et al.   MOLECULAR CELL

Conserved Antagonism between JMJD2A/KDM4A and HP1γ during Cell Cycle Progression

(2010) Joshua C. Black et al.   MOLECULAR CELL

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Lys-N and Trypsin Cover Complementary Parts of the Phosphoproteome in a Refined SCX-Based Approach

(2009) Sharon Gauci et al.   ANALYTICAL CHEMISTRY

Genome-Wide Views of Chromatin Structure

(2009) Oliver J. Rando et al.   Annual Review of Biochemistry

Identification of non-histone substrates for JMJD2A–C histone demethylases

(2009) V.K. Chaithanya Ponnaluri et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple SET Methyltransferases Are Required to Maintain Normal Heterochromatin Domains in the Genome of Drosophila melanogaster

(2009) B. Brower-Toland et al.   GENETICS

Cellular radiosensitivity: How much better do we understand it?

(2009) Penny Jeggo et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

High Throughput Characterization of Combinatorial Histone Codes

(2009) Nicolas L. Young et al.   MOLECULAR & CELLULAR PROTEOMICS

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

(2009) John R Horton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY