A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1

Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity

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Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells

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5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

(2013) Richard J. Hopkinson et al.   Chemical Science

The Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probes

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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

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Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

(2012) Wei Ge et al.   Nature Chemical Biology

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases

(2011) Xuelai Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of homogeneous luminescence assays for histone demethylase catalysis and binding

(2010) Akane Kawamura et al.   ANALYTICAL BIOCHEMISTRY

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

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Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans

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Photophysical Properties of 8-Hydroxyquinoline-5-sulfonic Acid as a Function of the pH: A TD-DFT Investigation

(2010) Tangui Le Bahers et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

(2010) Hank H. Qi et al.   NATURE

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates

(2010) Armin Thalhammer et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

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Photodynamic Therapy-Induced Apoptosis of HeLa Cells

(2009) Elisa Panzarini et al.   Annals of the New York Academy of Sciences

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2

(2009) Jasmin Mecinović et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors

(2009) Shohei Hamada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

(2009) John R Horton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

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Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

(2008) Anja Schuetz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expanding chemical biology of 2-oxoglutarate oxygenases

(2008) Christoph Loenarz et al.   Nature Chemical Biology