Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway

Salvianolic acid B protects against oxLDL-induced endothelial dysfunction under high-glucose conditions by downregulating ROCK1-mediated mitophagy and apoptosis

(2020) Young Shin Ko et al.   BIOCHEMICAL PHARMACOLOGY

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis

(2018) Yachun Han et al.   Redox Biology

Puerarin inhibits hyperglycemia-induced inter-endothelial junction through suppressing endothelial Nlrp3 inflammasome activation via ROS-dependent oxidative pathway

(2018) Dawei Lian et al.   PHYTOMEDICINE

Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway

(2017) Yanlin Yin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Type 2 diabetes

(2017) Sudesna Chatterjee et al.   LANCET

Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction

(2016) Yang Chen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE−/−Mice

(2016) Weiling Leng et al.   MEDIATORS OF INFLAMMATION

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Inflammasome Activation in the Pathophysiology of Vascular Diseases of the Neurovascular Unit

(2015) Islam N. Mohamed et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

(2015) Xian Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

New insights into the pathophysiology of dyslipidemia in type 2 diabetes

(2015) Marja-Riitta Taskinen et al.   ATHEROSCLEROSIS

New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial Cells

(2015) Xiaoyu Li et al.   MOLECULAR ENDOCRINOLOGY

Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases

(2014) Andreja Trpkovic et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Effects of rosmarinic acid on an experimental model of painful diabetic neuropathy in rats

(2014) Parisa Hasanein et al.   PHARMACEUTICAL BIOLOGY

Rosmarinic acid administration attenuates diabetes-induced vascular dysfunction of the rat aorta

(2013) Ruzena Sotnikova et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The Thioredoxin System as a Therapeutic Target in Human Health and Disease

(2012) Dler Faieeq Darweesh Mahmood et al.   ANTIOXIDANTS & REDOX SIGNALING

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

Thioredoxin Interacting Protein: Redox Dependent and Independent Regulatory Mechanisms

(2011) Oded N. Spindel et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of Rosmarinic Acid on Experimental Diabetic Nephropathy

(2011) Wang-Lin Jiang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

NLRP3 inflammasomes link inflammation and metabolic disease

(2011) Dominic De Nardo et al.   TRENDS IN IMMUNOLOGY

Hyperglycemia and Oxidized-LDL exert a deleterious effect on Endothelial Progenitor Cell migration in Type 2 Diabetes Mellitus

(2010) Saher Hamed et al.   THROMBOSIS RESEARCH

Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells

(2009) Xiaonan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

NADPH Oxidases, Reactive Oxygen Species, and Hypertension: Clinical implications and therapeutic possibilities

(2008) T. M. Paravicini et al.   DIABETES CARE

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE