SIRT3 (Sirtuin-3) Prevents Ang II (Angiotensin II)–Induced Macrophage Metabolic Switch Improving Perivascular Adipose Tissue Function

NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling

(2019) Xabier Unamuno et al.   Cellular & Molecular Immunology

Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions

(2019) Tong Wei et al.   Cell Death & Disease

Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasome/IL-1 signaling pathway

(2018) Xiao Zhu et al.   ACTA PHARMACOLOGICA SINICA

Brown Adipocyte-Specific PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deletion Impairs Perivascular Adipose Tissue Development and Enhances Atherosclerosis in Mice

(2018) Wenhao Xiong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation

(2018) Penghao Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Obesity-induced mitochondrial dysfunction in porcine adipose tissue-derived mesenchymal stem cells

(2018) Yu Meng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Overexpression of Pyruvate dehydrogenase E1a subunit Inhibits Warburg effect and Induces Cell Apoptosis through Mitochondria-mediated Pathway in Hepatocellular Carcinoma

(2018) Jihong Sun et al.   ONCOLOGY RESEARCH

PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect

(2018) Dan Li et al.   Cell Death & Disease

Perivascular Adipose Tissue: the Sixth Man of the Cardiovascular System

(2018) Chak Kwong Cheng et al.   CARDIOVASCULAR DRUGS AND THERAPY

Glycolysis regulates LPS-induced cytokine production in M2 polarized human macrophages

(2017) Sayako Chiba et al.   IMMUNOLOGY LETTERS

Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning

(2017) Meshail Okla et al.   INFLAMMATION

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

(2017) Javier Traba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arterial stiffness as a risk factor for clinical hypertension

(2017) Michel E. Safar   Nature Reviews Cardiology

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Spontaneous hypertension occurs with adipose tissue dysfunction in perilipin-1 null mice

(2016) Liangqiang Zou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism

(2016) Yi Rang Na et al.   JOURNAL OF IMMUNOLOGY

Activation of the NLRP3 inflammasome induces vascular dysfunction in obese OLETF rats

(2015) Penghao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects

(2015) Javier Traba et al.   JOURNAL OF CLINICAL INVESTIGATION

Diet-induced obesity causes insulin resistance in mouse brown adipose tissue

(2015) Carla Roberts-Toler et al.   Obesity

SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells

(2015) Yang Cui et al.   PLoS One

Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

(2014) Dan Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats

(2014) Susana Vallejo et al.   Cardiovascular Diabetology

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

(2014) Ozkan Ozden et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of Mitochondrial Sirtuins Alters Glycolysis and Mitochondrial Function in HEK293 Cells

(2014) Michelle Barbi de Moura et al.   PLoS One

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

(2014) Liangchun Yang et al.   Nature Communications

Regulation of pyruvate metabolism and human disease

(2013) Lawrence R. Gray et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation

(2011) Timothy P. Fitzgibbons et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Macrophage Polarization by Angiotensin II-Type 1 Receptor Aggravates Renal Injury-Acceleration of Atherosclerosis

(2011) Suguru Yamamoto et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity

(2010) D. A. Hume   JOURNAL OF LEUKOCYTE BIOLOGY

A Method for Generation of Bone Marrow-Derived Macrophages from Cryopreserved Mouse Bone Marrow Cells

(2010) Fernanda M. Marim et al.   PLoS One

Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion

(2009) Akos A. Gerencser et al.   ANALYTICAL CHEMISTRY

The Inflammasomes

(2009) Mohamed Lamkanfi et al.   PLoS Pathogens