SOD1, more than just an antioxidant

Methylglyoxal interaction with superoxide dismutase 1

(2020) Panagis Polykretis et al.   Redox Biology

Analyzing structural alterations of mitochondrial intermembrane space superoxide scavengers cytochrome-c and SOD1 after methylglyoxal treatment

(2020) Hilda Mercado-Uribe et al.   PLoS One

RNA Dysregulation in Amyotrophic Lateral Sclerosis

(2019) Zoe Butti et al.   Frontiers in Genetics

SOD1 deficiency: a novel syndrome distinct from amyotrophic lateral sclerosis

(2019) Julien H Park et al.   BRAIN

Epidemiology of amyotrophic lateral sclerosis

(2019) Elisa Longinetti et al.   CURRENT OPINION IN NEUROLOGY

SOD1 is essential for oncogene-driven mammary tumor formation but dispensable for normal development and proliferation

(2019) Maria L. Gomez et al.   ONCOGENE

Mechanisms of SOD1 regulation by post-translational modifications

(2019) C.J. Banks et al.   Redox Biology

Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation

(2019) Luke McAlary et al.   ANALYTICAL CHEMISTRY

Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1

(2019) Aline de Araújo Brasil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum Extracellular Superoxide Dismutase Is Associated with Diabetic Retinopathy Stage in Chinese Patients with Type 2 Diabetes Mellitus

(2018) Jin-Song Zhao et al.   DISEASE MARKERS

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

SOD1A4Vaggregation alters ubiquitin homeostasis in a cell model of ALS

(2018) Natalie E. Farrawell et al.   JOURNAL OF CELL SCIENCE

SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation

(2018) Chi Kwan Tsang et al.   MOLECULAR CELL

Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis

(2018) Danilo B. Medinas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extra-mitochondrial Cu/Zn superoxide dismutase (Sod1) is dispensable for protection against oxidative stress but mediates peroxide signaling in Saccharomyces cerevisiae

(2018) Claudia Montllor-Albalate et al.   Redox Biology

Unraveling new functions of superoxide dismutase using yeast model system: Beyond its conventional role in superoxide radical scavenging

(2017) Woo-Hyun Chung   JOURNAL OF MICROBIOLOGY

Oxygen-dependent activation of Cu,Zn-superoxide dismutase-1

(2017) Morgan M. Fetherolf et al.   Metallomics

Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration

(2017) Courtney J. Banks et al.   MOLECULAR AND CELLULAR BIOLOGY

Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models

(2017) Aline A. Brasil et al.   MOLECULAR NEUROBIOLOGY

S-acylation of SOD1, CCS and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects

(2017) Sarah E. Antinone et al.   Scientific Reports

ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models

(2017) Nimrod Rotem et al.   Scientific Reports

Hydrogen peroxide-mediated induction of SOD1 gene transcription is independent from Nrf2 in a cellular model of neurodegeneration

(2016) Michela Dell'Orco et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Effect of Oxidative Damage on the Stability and Dimerization of Superoxide Dismutase 1

(2016) Drazen Petrov et al.   BIOPHYSICAL JOURNAL

Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis

(2016) Nikolas Santamaria et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expanding roles of superoxide dismutases in cell regulation and cancer

(2016) Meixia Che et al.   DRUG DISCOVERY TODAY

New links betweenSOD1and metabolic dysfunction from a yeast model of Amyotrophic Lateral Sclerosis (ALS)

(2016) Emma L. Bastow et al.   JOURNAL OF CELL SCIENCE

Gibbs Energy of Superoxide Dismutase Heterodimerization Accounts for Variable Survival in Amyotrophic Lateral Sclerosis

(2016) Yunhua Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modeling ALS with motor neurons derived from human induced pluripotent stem cells

(2016) Samuel Sances et al.   NATURE NEUROSCIENCE

ALS: A bucket of genes, environment, metabolism and unknown ingredients

(2016) Mónica Zufiría et al.   PROGRESS IN NEUROBIOLOGY

A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation

(2016) James M. Fay et al.   STRUCTURE

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity

(2016) Luke McAlary et al.   Frontiers in Neuroscience

Local Destabilization of the Metal-Binding Region in Human Copper–Zinc Superoxide Dismutase by Remote Mutations Is a Possible Determinant for Progression of ALS

(2015) Janosch Hennig et al.   BIOCHEMISTRY

A fruitful endeavor: Modeling ALS in the fruit fly

(2015) Ian Casci et al.   BRAIN RESEARCH

α-synuclein interacts with SOD1 and promotes its oligomerization

(2015) Anika M. Helferich et al.   Molecular Neurodegeneration

Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents

(2015) Chenchu Lin et al.   Oncotarget

Cloning and expression analysis ofDrosophilaextracellular Cu Zn superoxide dismutase

(2014) Michael J. Blackney et al.   BIOSCIENCE REPORTS

Common Ground: Stem Cell Approaches Find Shared Pathways Underlying ALS

(2014) Soledad Matus et al.   Cell Stem Cell

Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons

(2014) Hong Chen et al.   Cell Stem Cell

Dimerization, Oligomerization, and Aggregation of Human Amyotrophic Lateral Sclerosis Copper/Zinc Superoxide Dismutase 1 Protein Mutant Forms in Live Cells

(2014) Jiho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DJ-1 Is a Copper Chaperone Acting on SOD1 Activation

(2014) Stefania Girotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOD2 to SOD1 Switch in Breast Cancer

(2014) Luena Papa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis

(2014) Birgit Schittek et al.   Molecular Cancer

Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes

(2014) Yves Maury et al.   NATURE BIOTECHNOLOGY

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nitric Oxide-Mediated Antioxidative Mechanism in Yeast through the Activation of the Transcription Factor Mac1

(2014) Ryo Nasuno et al.   PLoS One

Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation

(2014) Jared R. Auclair et al.   PROTEOMICS

Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

(2014) Chi Kwan Tsang et al.   Nature Communications

SOD1 oxidation and formation of soluble aggregates in yeast: Relevance to sporadic ALS development

(2014) Dorival Martins et al.   Redox Biology

Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans

(2014) Martine Therrien et al.   Frontiers in Genetics

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Consequences of Cysteinylation of Cu/Zn-Superoxide Dismutase

(2013) Jared R. Auclair et al.   BIOCHEMISTRY

Post-Translational Modification by Cysteine Protects Cu/Zn-Superoxide Dismutase from Oxidative Damage

(2013) Jared R. Auclair et al.   BIOCHEMISTRY

The glucose signaling network in yeast

(2013) Jeong-Ho Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Is SOD1 loss of function involved in amyotrophic lateral sclerosis?

(2013) Rachele A. Saccon et al.   BRAIN

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration

(2013) Amit R. Reddi et al.   CELL

Intrinsically Semi-disordered State and Its Role in Induced Folding and Protein Aggregation

(2013) Tuo Zhang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Advances in characterizing ubiquitylation sites by mass spectrometry

(2013) Kathrine B Sylvestersen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The involvement of GSH in the activation of human Sod1 linked to FALS in chronologically aged yeast cells

(2013) Aline A. Brasil et al.   FEMS YEAST RESEARCH

Palmitoylation of Superoxide Dismutase 1 (SOD1) Is Increased for Familial Amyotrophic Lateral Sclerosis-linked SOD1 Mutants

(2013) Sarah E. Antinone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship between ethanol and oxidative stress in laboratory and brewing yeast strains

(2013) Iulia Bleoanca et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Targeting SOD1 reduces experimental non–small-cell lung cancer

(2013) Andrea Glasauer et al.   JOURNAL OF CLINICAL INVESTIGATION

Posttranscriptional regulation of SOD1 gene expression under oxidative stress: Potential role of ELAV proteins in sporadic ALS

(2013) Pamela Milani et al.   NEUROBIOLOGY OF DISEASE

Wild-type Cu/Zn superoxide dismutase stabilizes mutant variants by heterodimerization

(2013) Anna Weichert et al.   NEUROBIOLOGY OF DISEASE

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutrient signaling to mTOR and cell growth

(2013) Jenna L. Jewell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Stress granules and cell signaling: more than just a passing phase?

(2013) Nancy Kedersha et al.   TRENDS IN BIOCHEMICAL SCIENCES

An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis

(2013) Melissa S. Rotunno et al.   Frontiers in Cellular Neuroscience

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis

(2013) Luke McAlary et al.   Scientific Reports

Cu(I) Affinities of the Domain 1 and 3 Sites in the Human Metallochaperone for Cu,Zn-Superoxide Dismutase

(2012) Stephen Allen et al.   BIOCHEMISTRY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Endothelial Cell Palmitoylproteomic Identifies Novel Lipid-Modified Targets and Potential Substrates for Protein Acyl Transferases

(2012) Ethan P. Marin et al.   CIRCULATION RESEARCH

Nutritional Control of Growth and Development in Yeast

(2012) J. R. Broach   GENETICS

ROS, autophagy, mitochondria and cancer: Ras, the hidden master?

(2012) Gregory L. Bellot et al.   MITOCHONDRION

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1

(2012) S. Guareschi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection

(2011) Zhiquan Wang et al.   ANNALS OF NEUROLOGY

Glutathionylation at Cys-111 Induces Dissociation of Wild Type and FALS Mutant SOD1 Dimers

(2011) Rachel L. Redler et al.   BIOCHEMISTRY

Post-Translational Modification of Cu/Zn Superoxide Dismutase under Anaerobic Conditions

(2011) Jeffry M. Leitch et al.   BIOCHEMISTRY

Yeast copper-dependent transcription factor ACE1 enhanced copper stress tolerance in Arabidopsis

(2011) Jing Xu et al.   BMB Reports

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond

(2011) Sandrine Da Cruz et al.   CURRENT OPINION IN NEUROBIOLOGY

Identification ofDrosophilaSOD3 and its protective role against phototoxic damage to cells

(2011) Inhee Jung et al.   FEBS LETTERS

Metabolic alterations in yeast lacking copper–zinc superoxide dismutase

(2011) Sadaf Sehati et al.   FREE RADICAL BIOLOGY AND MEDICINE

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

Muscle cells and motoneurons differentially remove mutant SOD1 causing familial amyotrophic lateral sclerosis

(2011) Elisa Onesto et al.   JOURNAL OF NEUROCHEMISTRY

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

(2011) R. Somwar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Warburg Effect and Redox Balance

(2011) R. B. Hamanaka et al.   SCIENCE

Import, Maturation, and Function of SOD1 and Its Copper Chaperone CCS in the Mitochondrial Intermembrane Space

(2010) Hibiki Kawamata et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D2concept

(2010) Vladimir N Uversky   Expert Review of Proteomics

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Metal-Free ALS Variants of Dimeric Human Cu,Zn-Superoxide Dismutase Have Enhanced Populations of Monomeric Species

(2010) Anna-Karin E. Svensson et al.   PLoS One

Novel Antibodies Reveal Inclusions Containing Non-Native SOD1 in Sporadic ALS Patients

(2010) Karin Forsberg et al.   PLoS One

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

(2010) Emanuele Buratti et al.   RNA Biology

Requirement of glutathione for Sod1 activation during lifespan extension

(2010) Sérgio C. Mannarino et al.   YEAST

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)

(2009) Kathryn Volkening et al.   BRAIN RESEARCH

Profiling the Human Protein-DNA Interactome Reveals ERK2 as a Transcriptional Repressor of Interferon Signaling

(2009) Shaohui Hu et al.   CELL

Rethinking ALS: The FUS about TDP-43

(2009) Clotilde Lagier-Tourenne et al.   CELL

The influence of yeast oxygenation prior to brewery fermentation on yeast metabolism and the oxidative stress response

(2009) Pieter J. Verbelen et al.   FEMS YEAST RESEARCH

Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse

(2009) L. Wang et al.   HUMAN MOLECULAR GENETICS

Amyotrophic Lateral Sclerosis-linked Mutant SOD1 Sequesters Hu Antigen R (HuR) and TIA-1-related Protein (TIAR)

(2009) Liang Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of Human Extracellular Copper–Zinc Superoxide Dismutase at 1.7 Å Resolution: Insights into Heparin and Collagen Binding

(2009) Svetlana V. Antonyuk et al.   JOURNAL OF MOLECULAR BIOLOGY

Mitochondrial Ubiquitin Ligase MITOL Ubiquitinates Mutant SOD1 and Attenuates Mutant SOD1-induced Reactive Oxygen Species Generation

(2009) Ryo Yonashiro et al.   MOLECULAR BIOLOGY OF THE CELL

Insights into yeast adaptive response to the agricultural fungicide mancozeb: A toxicoproteomics approach

(2009) Pedro M. Santos et al.   PROTEOMICS

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Hitchhiking of Cu/Zn Superoxide Dismutase to Peroxisomes - Evidence for a Natural Piggyback Import Mechanism in Mammals

(2009) Markus Islinger et al.   TRAFFIC

Contribution of Yap1 towardsSaccharomyces cerevisiaeadaptation to arsenic-mediated oxidative stress

(2008) Regina A. Menezes et al.   BIOCHEMICAL JOURNAL

The Yeast Saccharomyces cerevisiae: A Versatile Model System for the Identification and Characterization of Bacterial Virulence Proteins

(2008) Keri A. Siggers et al.   Cell Host & Microbe

Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria

(2008) Hibiki Kawamata et al.   HUMAN MOLECULAR GENETICS

Dynamical roles of metal ions and the disulfide bond in Cu, Zn superoxide dismutase folding and aggregation

(2008) F. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA