The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme

Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold

(2020) Tarek S. Ibrahim et al.   BIOORGANIC CHEMISTRY

Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic h CA II and membrane-bound h CA IX isoforms

(2018) Mikhail Krasavin et al.   BIOORGANIC CHEMISTRY

Unprotected primary sulfonamide group facilitates ring-forming cascade en route to polycyclic [1,4]oxazepine-based carbonic anhydrase inhibitors

(2018) Alexander Sapegin et al.   BIOORGANIC CHEMISTRY

New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors

(2018) Halise Inci Gul et al.   BIOORGANIC CHEMISTRY

Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV, and IX inhibitors

(2018) Alessio Nocentini et al.   BIOORGANIC CHEMISTRY

Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site

(2018) Srishti Singh et al.   MOLECULES

Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition

(2018) Mam Y. Mboge et al.   PLoS One

Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma

(2018) Kazuma Okuno et al.   OncoTargets and Therapy

Quantitative assessment of specific carbonic anhydrase inhibitors effect on hypoxic cells using electrical impedance assays

(2017) Luciana Stanica et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Mohammad H Forouzanfar et al.   LANCET

Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

(2015) Khalid O Alfarouk et al.   Cancer Cell International

Designing carbonic anhydrase inhibitors for the treatment of breast cancer

(2015) Claudiu T Supuran et al.   Expert Opinion on Drug Discovery

Carbonic anhydrase IX inhibitors in cancer therapy: an update

(2015) Claudiu T Supuran et al.   Future Medicinal Chemistry

How many carbonic anhydrase inhibition mechanisms exist?

(2015) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Targeting Carbonic Anhydrase IX Activity and Expression

(2015) Brian Mahon et al.   MOLECULES

A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX

(2015) Melissa A. Pinard et al.   Acta Crystallographica Section F-Structural Biology Communications

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

(2015) Paul C. McDonald et al.   Oncotarget

Sulfonamides and their isosters as carbonic anhydrase inhibitors

(2014) Fabrizio Carta et al.   Future Medicinal Chemistry

Recent advances in the discovery of zinc-binding motifs for the development of carbonic anhydrase inhibitors

(2014) Jean-Yves Winum et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma

(2014) Dongjun Luo et al.   Biomed Research International

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Antitumor Efficacy of a Monoclonal Antibody That Inhibits the Activity of Cancer-Associated Carbonic Anhydrase XII

(2013) G. Gondi et al.   CANCER RESEARCH

Carbonic anhydrase inhibitors: an editorial

(2013) Claudiu T Supuran   EXPERT OPINION ON THERAPEUTIC PATENTS

Anticancer carbonic anhydrase inhibitors: a patent review (2008 – 2013)

(2013) Simona Maria Monti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)

(2013) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Investigating the Selectivity of Metalloenzyme Inhibitors

(2013) Joshua A. Day et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV

(2012) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases

(2012) Leonardo E. Riafrecha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Insights towards sulfonamide drug specificity in α-carbonic anhydrases

(2012) Mayank Aggarwal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of the β-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: Identification of the first inhibitor with anti-mycobacterial activity

(2012) María V. Buchieri et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors

(2012) David P. Martin et al.   CHEMICAL COMMUNICATIONS

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Update on carbonic anhydrase inhibitors: a patent review (2008 – 2011)

(2012) Mayank Aggarwal et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

(2012) Kaspars Tars et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?

(2012) P. Borst   Open Biology

Carbonic anhydrase inhibitors and activators for novel therapeutic applications

(2011) Claudiu T Supuran   Future Medicinal Chemistry

Carbonic anhydrase inhibitors:in vitroinhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids

(2011) Derya Ekinci et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Natural Product-Based Phenols as Novel Probes for Mycobacterial and Fungal Carbonic Anhydrases

(2011) Rohan A. Davis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I–XIV with a series of natural product polyphenols and phenolic acids

(2010) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule

(2010) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibody-specific detection of CAIX in breast and prostate cancers

(2009) Ying Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols

(2009) Murat Şentürk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library

(2009) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent Advances in Cancer Therapy: An Overview

(2009) A. Urruticoechea et al.   CURRENT PHARMACEUTICAL DESIGN

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II

(2008) Esra Bayram et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I–XIV with a series of substituted phenols including paracetamol and salicylic acid

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I–XIV)

(2008) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide–isozyme II adduct

(2008) Claudia Temperini et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited—old leads for new applications?

(2008) Claudia Temperini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY