Tau‐induced upregulation of C/EBPβ‐TRPC1‐SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration

Tau accumulation triggers STAT1‐dependent memory deficits by suppressing NMDA receptor expression

(2019) Xiao‐Guang Li et al.   EMBO REPORTS

Naja atra Cardiotoxin 3 Elicits Autophagy and Apoptosis in U937 Human Leukemia Cells through the Ca2+/PP2A/AMPK Axis

(2019) Jing-Ting Chiou et al.   Toxins

Dietary salt promotes cognitive impairment through tau phosphorylation

(2019) Giuseppe Faraco et al.   NATURE

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

(2018) Ekaterina Pchitskaya et al.   CELL CALCIUM

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

(2018) Zhi-Hao Wang et al.   Nature Communications

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease

(2018) Yang-Ping Shentu et al.   Cell Reports

MPP+ decreases store-operated calcium entry and TRPC1 expression in Mesenchymal Stem Cell derived dopaminergic neurons

(2018) Yuyang Sun et al.   Scientific Reports

Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer’s disease

(2018) Hualong Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of L-Type Ca 2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons

(2017) Yuyang Sun et al.   JOURNAL OF NEUROSCIENCE

Presenilin-1 Delta E9 Mutant Induces STIM1-Driven Store-Operated Calcium Channel Hyperactivation in Hippocampal Neurons

(2017) Maria Ryazantseva et al.   MOLECULAR NEUROBIOLOGY

Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

(2017) Gao-Shang Chai et al.   Molecular Neurodegeneration

Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging

(2017) Michelle M. Mielke et al.   JAMA Neurology

Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model

(2016) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment

(2016) Hua Zhang et al.   JOURNAL OF NEUROSCIENCE

Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling

(2016) Yaling Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2

(2016) Yaling Yin et al.   Scientific Reports

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

(2015) Helois Radford et al.   ACTA NEUROPATHOLOGICA

Divergence in Endothelin-1- and Bradykinin-Activated Store-Operated Calcium Entry in Afferent Sensory Neurons

(2015) Kalina Szteyn et al.   ASN Neuro

Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease

(2015) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus

(2015) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation

(2015) Yixuan Wang et al.   NEUROBIOLOGY OF AGING

The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway

(2015) Yu-he Yuan et al.   TOXICOLOGY LETTERS

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

(2014) Suya Sun et al.   NEURON

Role of STIM1 in survival and neural differentiation of mouse embryonic stem cells independent of Orai1-mediated Ca2+ entry

(2014) Baixia Hao et al.   Stem Cell Research

Insulin Secretion and Ca2+Dynamics in β-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin

(2013) Rong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A)

(2012) Xu-Ying Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress

(2012) K H Tay et al.   Cell Death & Disease

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors

(2010) Jesús Avila et al.   Expert Review of Neurotherapeutics

The TRPC Class of Ion Channels: A Critical Review of Their Roles in Slow, Sustained Increases in Intracellular Ca2+ Concentrations

(2009) Lutz Birnbaumer   Annual Review of Pharmacology and Toxicology

Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

(2008) Y. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule-associated protein tau in development, degeneration and protection of neurons

(2008) Jian-Zhi Wang et al.   PROGRESS IN NEUROBIOLOGY