Precision medicine in Parkinson’s disease patients with LRRK2 and GBA risk variants – Let’s get even more personal
出版年份 2020 全文链接
标题
Precision medicine in Parkinson’s disease patients with LRRK2 and GBA risk variants – Let’s get even more personal
作者
关键词
-
出版物
Translational Neurodegeneration
Volume 9, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-10-16
DOI
10.1186/s40035-020-00218-x
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Lysosome and Inflammatory Defects in GBA1 ‐Mutant Astrocytes Are Normalized by LRRK2 Inhibition
- (2020) Anwesha Sanyal et al. MOVEMENT DISORDERS
- LRRK2 in Parkinson disease: challenges of clinical trials
- (2020) Eduardo Tolosa et al. Nature Reviews Neurology
- Leucine rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration.
- (2020) Zach Dwyer et al. NEUROBIOLOGY OF AGING
- Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson’s Disease?
- (2020) Christian U. von Linstow et al. Journal of Parkinsons Disease
- Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations
- (2020) Stephen Mullin et al. JAMA Neurology
- Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
- (2020) Matthew Taylor et al. CURRENT OPINION IN CELL BIOLOGY
- A Possible Modifying Effect of the G2019S Mutation in the LRRK2 Gene on GBA Parkinson's Disease
- (2020) Nurit Omer et al. MOVEMENT DISORDERS
- The Association Between Type 2 Diabetes Mellitus and Parkinson’s Disease
- (2020) Julia L.Y. Cheong et al. Journal of Parkinsons Disease
- Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients
- (2020) Omar S. Mabrouk et al. Frontiers in Neuroscience
- A novel rare variant of LRRK2 associated with familial Parkinson's disease: p.R1501W
- (2020) Satoshi Masuzugawa et al. PARKINSONISM & RELATED DISORDERS
- Parkinson's Disease and the Environment
- (2019) Nicole Ball et al. Frontiers in Neurology
- Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study
- (2019) Ronald B Postuma et al. BRAIN
- Ambroxol as a novel disease-modifying treatment for Parkinson’s disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial
- (2019) C. R. A. Silveira et al. BMC Neurology
- Higher urate in LRRK2 mutation carriers resistant to Parkinson disease
- (2019) Rachit Bakshi et al. ANNALS OF NEUROLOGY
- GBA, Gaucher Disease, and Parkinson’s Disease: From Genetic to Clinic to New Therapeutic Approaches
- (2019) Giulietta M. Riboldi et al. Cells
- Functionalization of the TMEM175 p.M393T Variant as a risk factor for Parkinson Disease
- (2019) Sarah Jinn et al. HUMAN MOLECULAR GENETICS
- The genetic architecture of Parkinson's disease
- (2019) Cornelis Blauwendraat et al. LANCET NEUROLOGY
- Glucocerebrosidase and its relevance to Parkinson disease
- (2019) Jenny Do et al. Molecular Neurodegeneration
- Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner
- (2019) Bojan Shutinoski et al. Science Translational Medicine
- Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies
- (2019) Lynne Krohn et al. ANNALS OF NEUROLOGY
- Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson’s disease
- (2019) Hampton Leonard et al. JOURNAL OF MEDICAL GENETICS
- A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease
- (2019) Lena F. Burbulla et al. Science Translational Medicine
- Genetic modifiers of risk and age at onset in GBA associated Parkinson’s disease and Lewy body dementia
- (2019) Cornelis Blauwendraat et al. BRAIN
- LRRK2 and GBA Variants Exert Distinct Influences on Parkinson’s Disease-Specific Metabolic Networks
- (2019) Katharina A Schindlbeck et al. CEREBRAL CORTEX
- Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
- (2019) Mike A Nalls et al. LANCET NEUROLOGY
- LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
- (2019) Daniel Ysselstein et al. Nature Communications
- Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study
- (2018) Rita Guerreiro et al. LANCET NEUROLOGY
- Association between diabetes and subsequent Parkinson disease
- (2018) Eduardo De Pablo-Fernandez et al. NEUROLOGY
- LRRK2 activation in idiopathic Parkinson’s disease
- (2018) Roberto Di Maio et al. Science Translational Medicine
- Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s disease
- (2018) Farzaneh Atashrazm et al. Scientific Reports
- Parkinson’s Disease in the Era of Personalised Medicine: One Size Does Not Fit All
- (2018) Lauren E. Ryden et al. DRUGS & AGING
- Carriers of both GBA and LRRK2 mutations, compared to carriers of either, in Parkinson's disease: Risk estimates and genotype-phenotype correlations
- (2018) Gilad Yahalom et al. PARKINSONISM & RELATED DISORDERS
- Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis
- (2018) Michaela E. Johnson et al. TRENDS IN NEUROSCIENCES
- GBA mutations in Parkinson disease: earlier death but similar neuropathological features
- (2017) C. H. Adler et al. EUROPEAN JOURNAL OF NEUROLOGY
- A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments
- (2017) Jérôme Stirnemann et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
- (2017) Dilan Athauda et al. LANCET
- Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials
- (2017) Alberto J. Espay et al. MOVEMENT DISORDERS
- Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature
- (2017) Susanne A. Schneider et al. MOVEMENT DISORDERS
- Personalized medicine in Parkinson's disease: Time to be precise
- (2017) Nataliya Titova et al. MOVEMENT DISORDERS
- Precision medicine for disease modification in Parkinson disease
- (2017) Alberto J. Espay et al. Nature Reviews Neurology
- Non-motor features of Parkinson disease
- (2017) Anthony H. V. Schapira et al. NATURE REVIEWS NEUROSCIENCE
- Glucocerebrosidase Mutations in Parkinson Disease
- (2017) Grace O’Regan et al. Journal of Parkinsons Disease
- Role of LRRK2 in the regulation of dopamine receptor trafficking
- (2017) Mauro Rassu et al. PLoS One
- Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's
- (2016) Ganqiang Liu et al. ANNALS OF NEUROLOGY
- Survival and dementia inGBA-associated Parkinson's disease: The mutation matters
- (2016) Roberto Cilia et al. ANNALS OF NEUROLOGY
- Advances in markers of prodromal Parkinson disease
- (2016) Ronald B. Postuma et al. Nature Reviews Neurology
- Microglia Priming with Aging and Stress
- (2016) Anzela Niraula et al. NEUROPSYCHOPHARMACOLOGY
- A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy
- (2016) Vinicius M. Fava et al. PLoS Neglected Tropical Diseases
- ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
- (2016) Hugo J.R. Fernandes et al. Stem Cell Reports
- Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models
- (2016) Alvaro Sanchez-Martinez et al. Scientific Reports
- Glucocerebrosidase activity in Parkinson’s disease with and withoutGBAmutations
- (2015) Roy N. Alcalay et al. BRAIN
- Biomarkers of Parkinson’s disease: Present and future
- (2015) Diane B. Miller et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Differential effects of severe vs mild GBA mutations on Parkinson disease
- (2015) Z. Gan-Or et al. NEUROLOGY
- Progress in unraveling the genetic etiology of Parkinson disease in a genomic era
- (2015) Aline Verstraeten et al. TRENDS IN GENETICS
- Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease
- (2015) Lorraine V. Kalia et al. JAMA Neurology
- Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?
- (2014) Amy Reeve et al. AGEING RESEARCH REVIEWS
- Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells
- (2014) Alisdair McNeill et al. BRAIN
- LRRK2 pathobiology in Parkinson's disease
- (2014) Ian Martin et al. JOURNAL OF NEUROCHEMISTRY
- The current and projected economic burden of Parkinson's disease in the United States
- (2013) Stacey L. Kowal et al. MOVEMENT DISORDERS
- Parkinson's Disease Biomarkers: Resources for Discovery and Validation
- (2013) Mark Frasier et al. NEUROPSYCHOPHARMACOLOGY
- Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus
- (2013) Daniah Trabzuni et al. PLoS One
- The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease
- (2013) Eleftheria K. Pissadaki et al. Frontiers in Computational Neuroscience
- Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
- (2012) Matthew E. Gegg et al. ANNALS OF NEUROLOGY
- Long-term clinical outcomes in type 1 Gaucher disease following 10 years of imiglucerase treatment
- (2012) Neal J. Weinreb et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Living on the edge with too many mouths to feed: Why dopamine neurons die
- (2012) J. Paul Bolam et al. MOVEMENT DISORDERS
- The neuropathology of genetic Parkinson's disease
- (2012) Markos Poulopoulos et al. MOVEMENT DISORDERS
- Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers
- (2012) M. Anheim et al. NEUROLOGY
- Gaucher disease gene GBA functions in immune regulation
- (2012) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antigen Processing for MHC Class II Presentation via Autophagy
- (2012) Christian Münz Frontiers in Immunology
- Clinical progression in Parkinson disease and the neurobiology of axons
- (2010) Hsiao-Chun Cheng et al. ANNALS OF NEUROLOGY
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage
- (2010) P. K. Mistry et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LRRK2 G2385R modulates age at onset in Parkinson's disease: A multi-center pooled analysis
- (2009) E.K. Tan et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
- (2009) Paolo Barone et al. MOVEMENT DISORDERS
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Metabolomic Profiling in LRRK2-Related Parkinson's Disease
- (2009) Krisztina K. Johansen et al. PLoS One
- Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease
- (2008) Owen A. Ross et al. ANNALS OF NEUROLOGY
- LRRK2 regulates synaptic vesicle endocytosis
- (2008) Narae Shin et al. EXPERIMENTAL CELL RESEARCH
- LRRK2 R1628P increases risk of Parkinson’s disease: replication evidence
- (2008) E. K. Tan et al. HUMAN GENETICS
- Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)
- (2008) Kathleen S. Hruska et al. HUMAN MUTATION
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset
- (2008) Z. Gan-Or et al. NEUROLOGY
- Progression of dopaminergic dysfunction in a LRRK2 kindred: A multitracer PET study
- (2008) R. Nandhagopal et al. NEUROLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started