High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans’ Lifespan

(2019) Peichuan Zhang et al.   G3-Genes Genomes Genetics

Mitochondrial Proteostasis in the Context of Cellular and Organismal Health and Aging

(2018) Erica A Moehle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy

(2018) Chitra Rajagopal et al.   PHARMACOLOGICAL RESEARCH

Building Biological Shields via Hormesis

(2018) Edward J. Calabrese et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tea Polyphenols in Promotion of Human Health

(2018) Naghma Khan et al.   Nutrients

Large-scale bioactivity analysis of the small-molecule assayed proteome

(2017) Tyler William H. Backman et al.   PLoS One

Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage

(2017) Shoujiao Peng et al.   Food & Function

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

(2016) Randy Strong et al.   AGING CELL

Repurposing FDA-approved drugs for anti-aging therapies

(2016) Terry W. Snell et al.   BIOGERONTOLOGY

New era of integrated cancer biomarker discovery using reverse-phase protein arrays

(2016) Satoshi S. Nishizuka et al.   Drug Metabolism and Pharmacokinetics

bioassayR: Cross-Target Analysis of Small Molecule Bioactivity

(2016) Tyler William H. Backman et al.   Journal of Chemical Information and Modeling

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span

(2016) Sandeep Kumar et al.   PLoS Genetics

Longevity and stress in Caenorhabditis elegans

(2016) Katherine I. Zhou et al.   Aging-US

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

A network pharmacology approach reveals new candidate caloric restriction mimetics inC. elegans

(2015) Shaun Calvert et al.   AGING CELL

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

(2015) Sharadha Dayalan Naidu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis

(2014) Guangchuang Yu et al.   BIOINFORMATICS

New insights into antioxidant strategies against paraquat toxicity

(2014) T. Blanco-Ayala et al.   FREE RADICAL RESEARCH

Fibroblasts From Longer-Lived Species of Primates, Rodents, Bats, Carnivores, and Birds Resist Protein Damage

(2014) Andrew M. Pickering et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A pharmacological network for lifespan extension inCaenorhabditis elegans

(2013) Xiaolan Ye et al.   AGING CELL

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

fmcsR: mismatch tolerant maximum common substructure searching in R

(2013) Yan Wang et al.   BIOINFORMATICS

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Measurement of Lifespan in Drosophila melanogaster

(2013) Nancy J. Linford et al.   Jove-Journal of Visualized Experiments

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity

(2011) Tsui-Ting Ching et al.   AGING CELL

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

(2011) Ying Zhang et al.   CHEMISTRY & BIOLOGY

Disease Ontology: a backbone for disease semantic integration

(2011) L. M. Schriml et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Thioredoxins and Glutaredoxins: Unifying Elements in Redox Biology

(2009) Yves Meyer et al.   Annual Review of Genetics

Cell Stress and Aging: New Emphasis on Multiplex Resistance Mechanisms

(2009) R. A. Miller   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nrf2 Signaling, a Mechanism for Cellular Stress Resistance in Long-Lived Mice

(2009) S. F. Leiser et al.   MOLECULAR AND CELLULAR BIOLOGY

ChemmineR: a compound mining framework for R

(2008) Y. Cao et al.   BIOINFORMATICS

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

(2008) K. J. Pearson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA