A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer
出版年份 2020 全文链接
标题
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer
作者
关键词
-
出版物
eLife
Volume 9, Issue -, Pages -
出版商
eLife Sciences Publications, Ltd
发表日期
2020-10-05
DOI
10.7554/elife.56749
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
- (2019) Shuo Qie et al. Nature Communications
- The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance
- (2019) Xing Huang et al. Autophagy
- LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma
- (2019) Ana Galan-Cobo et al. CANCER RESEARCH
- In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
- (2019) Milica Momcilovic et al. NATURE
- A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
- (2019) Hee Chan Yoo et al. Cell Metabolism
- Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation
- (2018) Elisabeth F. P. Peterse et al. BRITISH JOURNAL OF CANCER
- The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
- (2018) Milica Momcilovic et al. CANCER CELL
- Recent Development of Small Molecule Glutaminase Inhibitors
- (2018) Minsoo Song et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Metabolic vulnerability of cisplatin‐resistant cancers
- (2018) Florine Obrist et al. EMBO JOURNAL
- Glutathione metabolism in cancer progression and treatment resistance
- (2018) Ankita Bansal et al. JOURNAL OF CELL BIOLOGY
- Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial
- (2018) Masatoshi Kudo et al. LANCET
- Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
- (2018) Michael L Schulte et al. NATURE MEDICINE
- Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets
- (2018) Angelika Bröer et al. Frontiers in Pharmacology
- Glutamine addiction activates polyglutamine-based nanocarriers delivering therapeutic siRNAs to orthotopic lung tumor mediated by glutamine transporter SLC1A5
- (2018) Cuifeng Wang et al. BIOMATERIALS
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- SIRT 4 Depletion Promotes HCC Tumorigenesis through Regulating AMPK α/ mTOR Axis
- (2018) Yun‐shan Wang et al. HEPATOLOGY
- Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway
- (2018) Binghua Li et al. EBioMedicine
- A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis
- (2017) William P Katt et al. Future Medicinal Chemistry
- Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1
- (2017) Haojie Jin et al. GASTROENTEROLOGY
- Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers
- (2017) Arimichi Okazaki et al. JOURNAL OF CLINICAL INVESTIGATION
- Metabolic Imaging of Glutamine in Cancer
- (2017) Lin Zhu et al. JOURNAL OF NUCLEAR MEDICINE
- Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
- (2017) Jessica B. Spinelli et al. SCIENCE
- Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer
- (2017) Kristin K. Brown et al. Cancer Discovery
- Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition
- (2015) N. Jacque et al. BLOOD
- Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
- (2015) Yan Xiang et al. JOURNAL OF CLINICAL INVESTIGATION
- Determination of Phosphate-activated Glutaminase Activity and Its Kinetics in Mouse Tissues using Metabolic Mapping (Quantitative Enzyme Histochemistry)
- (2014) Dennis Botman et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
- (2014) M. I. Gross et al. MOLECULAR CANCER THERAPEUTICS
- Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
- (2013) Jaekyoung Son et al. NATURE
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors
- (2012) Luis E. Raez et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Prognostic PET 18F-FDG Uptake Imaging Features Are Associated with Major Oncogenomic Alterations in Patients with Resected Non-Small Cell Lung Cancer
- (2012) V. S. Nair et al. CANCER RESEARCH
- Preparation and Characterization of L-[5-11C]-Glutamine for Metabolic Imaging of Tumors
- (2011) W. Qu et al. JOURNAL OF NUCLEAR MEDICINE
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started