Glutathione metabolism in cancer progression and treatment resistance

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility

(2017) Chun-Shik Shin et al.   Nature Communications

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

(2017) Volkan I Sayin et al.   eLife

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma

(2016) A. Ari Hakimi et al.   CANCER CELL

Glutathione Depletion, Pentose Phosphate Pathway Activation, and Hemolysis in Erythrocytes Protecting Cancer Cells from Vitamin C-induced Oxidative Stress

(2016) Zhuzhen Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

(2016) Evan C. Lien et al.   NATURE CELL BIOLOGY

A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma

(2016) Judith G. Villablanca et al.   PEDIATRIC BLOOD & CANCER

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

(2016) Meng-Chen Lu et al.   Scientific Reports

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis

(2016) Xinlei Yu et al.   Scientific Reports

Genetic Variations in Glutathione Pathway Genes Predict Cancer Recurrence in Patients Treated with Transurethral Resection and Bacillus Calmette–Guerin Instillation for Non-muscle Invasive Bladder Cancer

(2015) Hung-Lung Ke et al.   ANNALS OF SURGICAL ONCOLOGY

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

(2015) John D. Hayes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Human γ-Glutamyl Transpeptidase 1

(2015) Simon S. Terzyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic regulation of T cell differentiation and function

(2015) Benjamin V. Park et al.   MOLECULAR IMMUNOLOGY

Involvement of glutathione and glutathione metabolizing enzymes in human colorectal cancer cell lines and tissues

(2015) AREUM DASEUL KIM et al.   Molecular Medicine Reports

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Oxidative Stress and Antioxidants in Disease and Cancer: A Review

(2014) Rakesh Kumar Gupta et al.   Asian Pacific Journal of Cancer Prevention

Pretherapeutic gamma-glutamyltransferase is an independent prognostic factor for patients with renal cell carcinoma

(2014) S L Hofbauer et al.   BRITISH JOURNAL OF CANCER

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma

(2014) A Tagde et al.   Blood Cancer Journal

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione levels in human tumors

(2012) Michael P. Gamcsik et al.   BIOMARKERS

Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies

(2012) Concetta Conticello et al.   INTERNATIONAL JOURNAL OF CANCER

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

S-adenosylmethionine in Liver Health, Injury, and Cancer

(2012) Shelly C. Lu et al.   PHYSIOLOGICAL REVIEWS

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Regulation of γ-Glutamyl Transpeptidase

(2009) Hongqiao Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE