Review
Obstetrics & Gynecology
Maryam Kazemi, Joy Y. Kim, Stephen A. Parry, Ricardo Azziz, Marla E. Lujan
Summary: The systematic review and meta-analysis revealed that Black women with polycystic ovary syndrome have a greater tendency for adverse cardiometabolic risk profile compared to White women, despite lower triglyceride levels. These findings emphasize the importance of considering these disparities in diagnostic, monitoring, and management practices in Black women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Obstetrics & Gynecology
Maryam Kazemi, Joy Y. Kim, Cynthia Wan, Julia D. Xiong, Stephen A. Parry, Ricardo Azziz, Marla E. Lujan
Summary: This study compared the cardiometabolic and reproductive health risk between Hispanic and White women with polycystic ovary syndrome in the United States. It found that Hispanic women had greater impairments in glucoregulatory status but no significant differences in reproductive risks could be concluded.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Chemistry, Analytical
Anna Rajska, Magdalena Buszewska-Forajta, Szymon Macioszek, Renata Wawrzyniak, Pawel Wityk, Andrzej Berg, Agnieszka Kowalewska, Dominik Rachon, Michal J. Markuszewski
Summary: Despite numerous studies, the cause of PCOS remains unknown. To confirm the reliability of proposed metabolomics biomarkers, we conducted a validation study on serum and urine samples from PCOS patients and healthy controls. Our analysis identified a comprehensive set of altered metabolites in PCOS patients, indicating disruptions in hormone synthesis, lipid metabolism, and energy production.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Endocrinology & Metabolism
Kexin Wang, Yanhua Li
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The etiologies of this syndrome are complex and involve prenatal factors, genetic variation, epigenetic mechanisms, unhealthy lifestyles, and environmental toxins. This review examines the molecular mechanisms underlying PCOS pathogenesis at the level of signaling pathways and discusses potential therapies including exosome therapy, gene therapy, and drugs based on traditional Chinese medicine and natural compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Hui He, Jiaxing Feng, Shike Zhang, Yu Wang, Jian Li, Jingshu Gao, Jing Cong, Yi Gong, Xiaoke Wu
Summary: The study found that there is a positive association between the ApoB/ApoA1 ratio and metabolic and endocrine parameters in women with PCOS. Higher ratios were also associated with increased risk of MetS and IR. The ratio could be a useful tool for screening MetS and IR in PCOS patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Zhijing Na, Hongyu Jiang, Yaxin Meng, Bei Shi, Da Li
Summary: This study analyzed the association between leptin and polycystic ovary syndrome (PCOS). The results showed that serum leptin levels were significantly higher in patients with PCOS and were associated with multiple metabolic markers. Combined detection of leptin and anti-Mullerian hormone (AMH) had high accuracy in diagnosing PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hosna Mohammad Sadeghi, Ida Adeli, Daniela Calina, Anca Oana Docea, Taraneh Mousavi, Marzieh Daniali, Shekoufeh Nikfar, Aristidis Tsatsakis, Mohammad Abdollahi
Summary: PCOS is an endocrine-gynecology disorder affecting women of childbearing age, with incomplete understanding of its etiology and pathophysiology. Lifestyle modifications and alternative medicines are the preferred first-line therapy, and certain medications have shown potential for repurposing in PCOS. Further research and well-designed clinical trials are needed, as the current evidence is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Khulood Hussein, Mohammed Karami
Summary: This study aimed to investigate the relationship between the level of menstrual abnormalities and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS). The results showed that women with PCOS had higher body mass index (BMI) and HOMA-IR values compared to the controls. Moreover, the severity of menstrual irregularity was positively correlated with the levels of luteinizing hormone/follicle-stimulating hormone and testosterone. Therefore, menstrual dysfunction can be used to predict insulin resistance in PCOS cases.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Endocrinology & Metabolism
P. Falcetta, E. Benelli, A. Molinaro, C. Di Cosmo, B. Bagattini, S. Del Ghianda, G. Salvetti, E. Fiore, E. Pucci, F. Fruzzetti, M. Tonacchera
Summary: The study found that the clinical features and metabolic abnormalities of PCOS women vary with age. Young PCOS women are more likely to have clinical and biochemical hyperandrogenism, while metabolic burden tends to increase with age. Furthermore, there is a stronger relationship between BMI and most metabolic outcomes, regardless of age.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Nazia Begum, Kandavalli Manipriya, B. Veeresh
Summary: This study developed a new animal model by combining a high-fat diet with letrozole to better simulate polycystic ovary syndrome (PCOS). Compared to the letrozole-only model, this new model can better demonstrate metabolic anomalies observed in PCOS.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Yi Zhai, Yanli Pang
Summary: PCOS is a common disorder related to endocrine/reproductive/metabolic systems, and it is associated with low-grade chronic inflammation. Patients with PCOS have higher levels of inflammatory cells and factors, as well as lower levels of anti-inflammatory cytokines. This systemic inflammation is thought to interact with obesity, insulin resistance, and hyperandrogenism.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yidan Xu, Huiqiu Zhu, Weiwei Li, Danxia Chen, Ying Xu, Aimin Xu, Dewei Ye
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a close link to obesity and related metabolic disorders. Adipokines produced by hypertrophic adipocytes in obesity play crucial roles in regulating glucose and lipid metabolism. Adipokine-targeted drugs may provide new therapeutic strategies for PCOS.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Nutrition & Dietetics
Malgorzata Mizgier, Grazyna Jarzabek-Bielecka, Natalia Wendland, Elzbieta Jodlowska-Siewert, Marcin Nowicki, Alicja Brozek, Witold Kedzia, Dorota Formanowicz, Justyna Opydo-Szymaczek
Summary: The study found associations between different nutrient intakes and inflammation and oxidative stress in PCOS females. Decreased plant protein intake and low carbohydrate intake may increase inflammation and oxidative stress, while cholesterol intake may increase inflammation levels.
Review
Biochemistry & Molecular Biology
Maedeh Babapour, Hamed Mohammadi, Maryam Kazemi, Amir Hadi, Mahsa Rezazadegan, Gholamreza Askari
Summary: Women with PCOS have lower serum magnesium concentrations compared to the control group, especially in overweight or obese women. Further research and management of magnesium status may be crucial for this clinical population.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Letter
Endocrinology & Metabolism
Maryam Kazemi, Anna E. Thalacker-Mercer, Marla E. Lujan
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Obstetrics & Gynecology
Maryam Kazemi, Joy Y. Kim, Stephen A. Parry, Ricardo Azziz, Marla E. Lujan
Summary: The systematic review and meta-analysis revealed that Black women with polycystic ovary syndrome have a greater tendency for adverse cardiometabolic risk profile compared to White women, despite lower triglyceride levels. These findings emphasize the importance of considering these disparities in diagnostic, monitoring, and management practices in Black women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Food Science & Technology
Amir Hadi, Makan Pourmasoumi, Maryam Kazemi, Ameneh Najafgholizadeh, Wolfgang Marx
Summary: Synbiotic interventions significantly reduce systolic blood pressure in adults, especially in longer trials, as supplements, and with younger participants. Significant improvements in both systolic and diastolic blood pressure levels were seen in subgroups with lower body mass index (<30 kg/m(2)).
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Toxicology
Cyrus Jalili, Maryam Kazemi, Hefa Cheng, Hamed Mohammadi, Atefeh Babaei, Ensiyeh Taheri, Sajjad Moradi
Summary: The study found that exposure to heavy metals such as cadmium, lead, and arsenic may increase the risk of chronic kidney disease in adults, with lead exposure being associated with decreased estimated glomerular filtration rate and increased proteinuria risk.
CRITICAL REVIEWS IN TOXICOLOGY
(2021)
Review
Endocrinology & Metabolism
Maryam Kazemi, Roger A. Pierson, Stephen A. Parry, Mojtaba Kaviani, Philip D. Chilibeck
Summary: Women with polycystic ovary syndrome (PCOS) do not show significant differences in muscle lean tissue mass compared to controls, but they do have an increase in this metric related to overweight/obesity, unrelated to hyperandrogenism or insulin resistance.
Article
Integrative & Complementary Medicine
Omid Asbaghi, Sara Kashkooli, Mahnaz Mardani, Mahnaz Rezaei Kelishadi, Hillary Fry, Maryam Kazemi, Mojtaba Kaviani
Summary: Green coffee bean extract supplementation may reduce systemic inflammation in overweight/obese individuals, as indicated by lower levels of TNF-alpha. Further investigations are needed to understand the potential cellular and molecular mechanisms behind this effect.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Review
Obstetrics & Gynecology
Maryam Kazemi, Joy Y. Kim, Cynthia Wan, Julia D. Xiong, Stephen A. Parry, Ricardo Azziz, Marla E. Lujan
Summary: This study compared the cardiometabolic and reproductive health risk between Hispanic and White women with polycystic ovary syndrome in the United States. It found that Hispanic women had greater impairments in glucoregulatory status but no significant differences in reproductive risks could be concluded.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Nutrition & Dietetics
Arman Arab, Fariborz Khorvash, Maryam Kazemi, Zahra Heidari, Gholamreza Askari
Summary: The study showed that the Dietary Approaches to Stop Hypertension (DASH) diet can improve health outcomes in women with migraines by reducing migraine frequency and severity, as well as decreasing depression and stress levels. Further research is needed to confirm the findings.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Food Science & Technology
Amir Hadi, Omid Asbaghi, Maryam Kazemi, Hossein Khadem Haghighian, Ana Pantovic, Ehsan Ghaedi, Firoozeh Abolhasani Zadeh
Summary: Consuming pistachio nuts can lower TC, LDL-C, and TG levels, but does not affect HDL-C levels. Consuming pistachio nuts may improve lipid profiles and protect against cardiometabolic diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Obstetrics & Gynecology
Maryam Kazemi, Joy Y. Kim, Cynthia Wan, Julia D. Xiong, Julia Michalak, Isabella B. Xavier, Kiran Ganga, Chau Thien Tay, Jessica A. Grieger, Stephen A. Parry, Lisa J. Moran, Marla E. Lujan
Summary: This study aimed to explore and compare the dietary and physical activity behaviors between women with polycystic ovary syndrome (PCOS) and those without PCOS. The findings indicated that women with PCOS had lower overall diet quality, poorer dietary intake (higher cholesterol and lower magnesium and zinc), and lower levels of physical activity compared to women without PCOS. These results highlight the need for targeted interventions to address these lifestyle behaviors in order to manage the complications associated with PCOS.
HUMAN REPRODUCTION UPDATE
(2022)
Review
Nutrition & Dietetics
Amir Hadi, Omid Asbaghi, Maryam Kazemi, Hossein Khadem Haghighian, Ehsan Ghaedi
Summary: This systematic review and meta-analysis evaluated the effects of pistachio consumption on glucoregulatory status in individuals with a high risk of cardiovascular disease (CVD). The results showed that pistachio consumption, isocaloric with other foods, can decrease fasting blood sugar and insulin concentrations in individuals with a high risk of CVD. However, there was no significant change in insulin resistance levels. It is recommended to conduct well-designed trials with an adequate sample size focusing on diabetic populations due to the limited availability of studies with diabetic cases and relatively small sample sizes.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Public, Environmental & Occupational Health
Seyadeh Narges Mazloomi, Sepide Talebi, Maryam Kazemi, Seyed Mojtaba Ghoreishy, Seyedeh Parisa Moosavian, Parsa Amirian, Hamed Mohammadi, Saeedeh Nouri-Majd, Wolfgang Marx, Mohammad Ali Hojjati Kermani, Sajjad Moradi
Summary: This study examined the association between food insecurity and sleep quality and quantity in adults. The results showed that food insecurity was associated with an increased risk of poor sleep quality and inconsistent sleep duration. Addressing food insecurity can have a positive impact on sleep in adults.
PUBLIC HEALTH NUTRITION
(2023)
Article
Neurosciences
Arghavan Balali, Elham Karimi, Maryam Kazemi, Amir Hadi, Gholamreza Askari, Fariborz Khorvash, Arman Arab
Summary: This study evaluated the association between diet quality and migraine outcomes. The results showed that improved diet quality was associated with lower migraine frequency, severity, and migraine-related disability. Further research is needed to confirm these findings and explore the causal mechanisms.
NUTRITIONAL NEUROSCIENCE
(2023)
Review
Nutrition & Dietetics
Chong-Su Kim
Summary: The gut microbiota plays a crucial role in brain function through the gut-brain axis. This review highlights the effects of gut microbiota-derived dietary metabolites on cell-to-cell interactions in the central nervous system, particularly microglia, astrocytes, and neuronal cells, affecting cognitive function, mood, and behavior. The review also discusses the potential of diet-induced microbial metabolite-based therapies as novel approaches to mental health treatment.
ADVANCES IN NUTRITION
(2024)