Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice

Systemic Therapy for Metastatic Renal-Cell Carcinoma

(2017) Toni K. Choueiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma

(2017) Amrita M. Nargund et al.   Cell Reports

Renal cell carcinoma

(2017) James J. Hsieh et al.   Nature Reviews Disease Primers

Formation of Renal Cysts and Tumors inVhl/Trp53-Deficient Mice Requires HIF1α and HIF2α

(2016) Désirée Schönenberger et al.   CANCER RESEARCH

Combined deletion ofVhl,Trp53andKif3acauses cystic and neoplastic renal lesions

(2016) Anna Guinot et al.   JOURNAL OF PATHOLOGY

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

(2016) Hyejin Cho et al.   NATURE

A Clearer View of the Molecular Complexity of Clear Cell Renal Cell Carcinoma

(2015) Ian J. Frew et al.   Annual Review of Pathology-Mechanisms of Disease

Tumour-suppressivemicroRNA-29sdirectly regulateLOXL2expression and inhibit cancer cell migration and invasion in renal cell carcinoma

(2015) Rika Nishikawa et al.   FEBS LETTERS

Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation

(2015) H. Lehmann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC)

(2015) Christopher J. Ricketts et al.   PLoS One

The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

(2014) Caleb F. Davis et al.   CANCER CELL

Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer

(2014) Jessica E.S. Shay et al.   CARCINOGENESIS

LOXL2 Status Correlates with Tumor Stage and Regulates Integrin Levels to Promote Tumor Progression in ccRCC

(2014) H. Hase et al.   MOLECULAR CANCER RESEARCH

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer

(2014) Peter M. K. Westcott et al.   NATURE

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

(2014) Marco Gerlinger et al.   NATURE GENETICS

The UCSC Genome Browser database: 2015 update

(2014) Kate R. Rosenbloom et al.   NUCLEIC ACIDS RESEARCH

Bap1is essential for kidney function and cooperates withVhlin renal tumorigenesis

(2014) Shan-Shan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Combined mutation ofVhlandTrp53causes renal cysts and tumours in mice

(2013) Joachim Albers et al.   EMBO Molecular Medicine

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Integrated molecular analysis of clear-cell renal cell carcinoma

(2013) Yusuke Sato et al.   NATURE GENETICS

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

EXCAVATOR: detecting copy number variants from whole-exome sequencing data

(2013) Alberto Magi et al.   GENOME BIOLOGY

RSeQC: quality control of RNA-seq experiments

(2012) Liguo Wang et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Gain of chromosome 8q is associated with metastases and poor survival of patients with clear cell renal cell carcinoma

(2012) Tobias Klatte et al.   CANCER

The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies

(2012) Junmin Pan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Of Mice and Men: Divergence of Gene Expression Patterns in Kidney

(2012) Lydie Cheval et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift

(2012) Pablo Cingolani et al.   Frontiers in Genetics

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors

(2011) Lee E. Moore et al.   PLoS Genetics

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney

(2009) R. Beroukhim et al.   CANCER RESEARCH

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma

(2008) John D. Gordan et al.   CANCER CELL

Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors

(2008) M. L. Nickerson et al.   CLINICAL CANCER RESEARCH

pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation

(2008) Ian J Frew et al.   EMBO JOURNAL

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia

(2008) Vishal Patel et al.   HUMAN MOLECULAR GENETICS

Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia

(2008) Peter Schraml et al.   MODERN PATHOLOGY