Synovial Sarcoma: A Complex Disease with Multifaceted Signaling and Epigenetic Landscapes

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

SS18-SSX-dependent YAP/TAZ Signaling in Synovial Sarcoma

(2019) Ilka Isfort et al.   CLINICAL CANCER RESEARCH

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

(2019) William Farnaby et al.   Nature Chemical Biology

The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

(2018) Matthew J. McBride et al.   CANCER CELL

Analysis of mutations in primary and metastatic synovial sarcoma

(2018) Zhuo Xing et al.   Oncotarget

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

(2018) Gerard L Brien et al.   eLife

Surgery alone is sufficient therapy for children and adolescents with low-risk synovial sarcoma: A joint analysis from the European paediatric soft tissue sarcoma Study Group and the Children's Oncology Group

(2017) Andrea Ferrari et al.   EUROPEAN JOURNAL OF CANCER

The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis

(2017) Jared J. Barrott et al.   MOLECULAR CANCER RESEARCH

Death by HDAC Inhibition in Synovial Sarcoma Cells

(2017) Aimée N. Laporte et al.   MOLECULAR CANCER THERAPEUTICS

siRNA Delivery Strategies: A Comprehensive Review of Recent Developments

(2017) Katyayani Tatiparti et al.   Nanomaterials

Functional and therapeutic relevance of hepatocyte growth factor/c-MET signaling in synovial sarcoma

(2016) Yoshinori Imura et al.   CANCER SCIENCE

Prognosis of T1 synovial sarcoma depends upon surgery by oncologic surgeons

(2016) Marc El Beaino et al.   JOURNAL OF SURGICAL ONCOLOGY

Profiling of potential driver mutations in sarcomas by targeted next generation sequencing

(2016) Carola Andersson et al.   Cancer Genetics

Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay

(2016) Aimée N. Laporte et al.   Oncotarget

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

(2016) Luisa Cironi et al.   Scientific Reports

Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

(2016) Satoshi Kawano et al.   PLoS One

Identification of a blood-borne miRNA signature of synovial sarcoma

(2015) Alba Fricke et al.   Molecular Cancer

Identification and analysis of CXCR4-positive synovial sarcoma-initiating cells

(2015) T Kimura et al.   ONCOGENE

Prognostic and predictive role of CXCR4, IGF-1R and Ezrin expression in localized synovial sarcoma: is chemotaxis important to tumor response?

(2015) Emanuela Palmerini et al.   Orphanet Journal of Rare Diseases

Next generation sequencing in synovial sarcoma reveals novel gene mutations

(2015) Myrella Vlenterie et al.   Oncotarget

Multi-platform profiling of over 2000 sarcomas: Identification of biomarkers and novel therapeutic targets

(2015) Sujana Movva et al.   Oncotarget

Long-term responders and survivors on pazopanib for advanced soft tissue sarcomas: subanalysis of two European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62043 and 62072

(2014) B. Kasper et al.   ANNALS OF ONCOLOGY

Tailored therapeutic strategies for synovial sarcoma: Receptor tyrosine kinase pathway analyses predict sensitivity to the mTOR inhibitor RAD001

(2014) Hirohiko Yasui et al.   CANCER LETTERS

Deflection of vascular endothelial growth factor action by SS18-SSX and composite vascular endothelial growth factor- and chemokine (C-X-C motif) receptor 4-targeted therapy in synovial sarcoma

(2014) Toru Wakamatsu et al.   CANCER SCIENCE

SS18-SSX-regulated miR-17 promotes tumor growth of synovial sarcoma by inhibiting p21WAF1/CIP1

(2014) Yusuke Minami et al.   CANCER SCIENCE

Cell-line authentication demystified

(2014) Vivien Marx   NATURE METHODS

Molecular Characterization of Synovial Sarcoma in Children and Adolescents: Evidence of Akt Activation

(2014) Fabio Bozzi et al.   Translational Oncology

Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells

(2013) Kazuo Hayakawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells

(2013) S. Michels et al.   CANCER RESEARCH

Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

(2013) Cigall Kadoch et al.   CELL

Sin3: Insight into its transcription regulatory functions

(2013) Rama Kadamb et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma

(2013) M Trautmann et al.   ONCOGENE

Targeting the Wnt Pathway in Synovial Sarcoma Models

(2013) W. Barham et al.   Cancer Discovery

Genome-wide recruitment to Polycomb-modified chromatin and activity regulation of the synovial sarcoma oncogene SYT-SSX2

(2012) Christina B Garcia et al.   BMC GENOMICS

Deconstruction of the SS18-SSX Fusion Oncoprotein Complex: Insights into Disease Etiology and Therapeutics

(2012) Le Su et al.   CANCER CELL

PDGF Receptor Alpha Is an Alternative Mediator of Rapamycin-Induced Akt Activation: Implications for Combination Targeted Therapy of Synovial Sarcoma

(2012) A. L. Ho et al.   CANCER RESEARCH

A novel multi-kinase inhibitor pazopanib suppresses growth of synovial sarcoma cells through inhibition of the PI3K-AKT pathway

(2012) Seiichi Hosaka et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Poorly differentiated synovial sarcoma is associated with high expression of enhancer of zeste homologue 2 (EZH2)

(2012) Yi-Che Changchien et al.   Journal of Translational Medicine

Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial

(2012) Winette TA van der Graaf et al.   LANCET

SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas

(2012) K B Jones et al.   ONCOGENE

SS18 Together with Animal-Specific Factors Defines Human BAF-Type SWI/SNF Complexes

(2012) Evelien Middeljans et al.   PLoS One

High-Frequency Canonical Wnt Activation in Multiple Sarcoma Subtypes Drives Proliferation through a TCF/β-Catenin Target Gene, CDC25A

(2011) Sapna Vijayakumar et al.   CANCER CELL

Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma

(2011) Hao-Wei Teng et al.   JOURNAL OF SURGICAL ONCOLOGY

Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT–SSX2

(2011) C B Garcia et al.   ONCOGENE

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

(2010) Boris G. Wilson et al.   CANCER CELL

MicroRNA miR-183 Functions as an Oncogene by Targeting the Transcription Factor EGR1 and Promoting Tumor Cell Migration

(2010) A. L. Sarver et al.   CANCER RESEARCH

The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy

(2010) Heath A. Smith et al.   Clinical & Developmental Immunology

TLE1 is a robust diagnostic biomarker for synovial sarcomas and correlates with t(X;18): Analysis of 319 cases

(2010) Thomas Knösel et al.   EUROPEAN JOURNAL OF CANCER

Identification of altered MicroRNA expression patterns in synovial sarcoma

(2010) Masanori Hisaoka et al.   GENES CHROMOSOMES & CANCER

Mutational analysis of E-cadherin, β-catenin and APC genes in synovial sarcomas

(2010) Manish Mani Subramaniam et al.   HISTOPATHOLOGY

Phosphatidylinositol-3′-kinase/AKT signaling is essential in synovial sarcoma

(2010) Nicolaus Friedrichs et al.   INTERNATIONAL JOURNAL OF CANCER

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

(2010) Jordi Barretina et al.   NATURE GENETICS

Synovial Sarcoma is a Stem Cell Malignancy

(2010) Norifumi Naka et al.   STEM CELLS

Molecular and immunohistochemical analyses of BCL2, KI-67, and cyclin D1 expression in synovial sarcoma

(2009) Lenka Krsková et al.   CANCER GENETICS AND CYTOGENETICS

Pazopanib, a Multikinase Angiogenesis Inhibitor, in Patients With Relapsed or Refractory Advanced Soft Tissue Sarcoma: A Phase II Study From the European Organisation for Research and Treatment of Cancer–Soft Tissue and Bone Sarcoma Group (EORTC Study 62043)

(2009) Stefan Sleijfer et al.   JOURNAL OF CLINICAL ONCOLOGY

Expression of insulin-like growth factor 2 in mesenchymal neoplasms

(2009) Sonja E Steigen et al.   MODERN PATHOLOGY

Activation of the non-canonical Dvl–Rac1–JNK pathway by Frizzled homologue 10 in human synovial sarcoma

(2009) C Fukukawa et al.   ONCOGENE

The Synovial Sarcoma-Associated SYT-SSX2 Oncogene Antagonizes the Polycomb Complex Protein Bmi1

(2009) Roy Barco et al.   PLoS One

Differential roles of SS18–SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth

(2008) Maria Törnkvist et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone Deacetylase Inhibitors Reverse SS18-SSX-Mediated Polycomb Silencing of the Tumor Suppressor Early Growth Response 1 in Synovial Sarcoma

(2008) J. M. Lubieniecka et al.   CANCER RESEARCH

Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays

(2008) Paolo Bianco et al.   Cell Stem Cell

Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma

(2008) N Friedrichs et al.   JOURNAL OF PATHOLOGY

Epidermal Growth Factor Receptor Expression and Mutational Analysis in Synovial Sarcomas and Malignant Peripheral Nerve Sheath Tumors

(2008) H. Tawbi et al.   ONCOLOGIST