Review
Pathology
Xiao Feng, Ya-Lan Huang, Zhen Zhang, Ning Wang, Qing Yao, Li-Juan Pang, Feng Li, Yan Qi
Summary: Synovial sarcoma is an aggressive malignancy characterized by biphasic differentiation, possibly linked to the pathognomonic t(X;18) translocation and the SYT-SSX fusion gene. Further research is needed on the pathogenic factors and treatment options for this cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Ke Pang, Xiaoning Guo, Yi Jiang, Lina Xu, Lin Ling, Zhihong Li
Summary: Primary intraosseous poorly differentiated synovial sarcoma is extremely rare. We present a case of this type of sarcoma from the proximal femur in a 16-year-old girl. The case was initially misdiagnosed but eventually confirmed by molecular testing. Recognition of this type of sarcoma composed of small round cells is crucial to avoid misdiagnosis as other types of tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yanli Cheng, Zhongtian Shen, Yaqi Gao, Feilong Chen, Huisha Xu, Qinling Mo, Xinlei Chu, Chang-liang Peng, Takese T. McKenzie, Bridgitte E. Palacios, Jian Hu, Hao Zhou, Jiafu Long
Summary: The study reveals that the binding of oncoprotein SS18-SSX to chromatin remodeling complex and its phase separation are crucial for the transformation activity in synovial sarcomas.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Review
Oncology
Esther Martinez-Font, Marina Perez-Capo, Oliver Vogler, Javier Martin-Broto, Regina Alemany, Antonia Obrador-Hevia
Summary: Soft tissue sarcomas are a heterogeneous group of rare tumors originating from mesenchymal tissue, with chemotherapy based on doxorubicin remaining the standard first-line treatment. Understanding the molecular alterations of the WNT signaling pathway in STS is crucial for developing new therapeutic approaches and identifying drug targets.
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Rabia Hayat, Maleeha Manzoor, Ali Hussain
Summary: Wnt signaling is an important evolutionary cell-to-cell coordination mechanism that plays a critical role in various physiological processes such as stem cell regeneration, cell division, and migration. This mechanism is regulated by a family of 19 proteins and can impact cellular processes through different pathways, with the Wnt/β-catenin signaling pathway playing a significant role in cancer progression.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Immunology
Yayun Xu, Zheng Lu, Yian Ling, Ruirui Hou, Jingjing Tao, Ge Deng, Xiaoling Xu, Xuewei Chen, Jingjing Ruan, Yihao Zhang, Xiaoqing Peng, Feihu Chen
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and joint destruction. Activated rheumatoid arthritis synovial fibroblasts (RASFs) exhibit tumor-like features. This study found that activation of acid-sensing ion channel 1a (ASIC1a) in an acidic environment promotes the proliferation of RASFs, which may involve the Wnt/β-catenin/c-Myc pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Chongyang Wang, Ruochen Hu, Liuyuan Duan, Qili Hou, Mengqing Yang, Ting Wang, Haijin Liu, Sa Xiao, Ruyi Dang, Juan Wang, Xinglong Wang, Shuxia Zhang, Zengqi Yang
Summary: This study showed that pseudorabies virus (PRV) infection activates the Wnt/beta-catenin signaling pathway, leading to enhanced virus proliferation and regulation of virus-induced autophagy. Inhibitors of this pathway can reduce PRV titers, while stimulation of the pathway can enhance PRV proliferation. These findings provide potential targets for the development of antiviral agents against PRV.
VETERINARY MICROBIOLOGY
(2022)
Article
Urology & Nephrology
Anand Raja, Ranganath Ratnagiri, Keerti Mss, Kanuj Malik, Arun R. Menon
Summary: Synovial sarcomas mainly occur in the extremities, but primary renal synovial sarcoma is rare. Diagnosis is established through surgery based on histopathology, immunohistochemistry, and chromosome studies. There are no established guidelines for adjuvant treatment, and surgery is the mainstay of treatment in reported cases.
UROLOGIA INTERNATIONALIS
(2022)
Review
Biochemistry & Molecular Biology
Xiaobin Shang, Kai Oliver Boeker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, Arndt F. Schilling
Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Manuel Pedro Jimenez-Garcia, Antonio Lucena-Cacace, Daniel Otero-Albiol, Amancio Carnero
Summary: Sarcomas are a heterogeneous group of tumors with a functional hierarchy controlled by sarcoma stem cells. EMX genes play a role in sarcomagenesis by regulating tumor stem cells, with a negative impact on tumorigenic properties. The relationship between EMX1/EMX2 and stem cell genes in sarcoma involves the canonical Wnt pathway, where EMX genes negatively regulate Wnt signaling to repress stemness and induce sarcomagenesis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Plant Sciences
Weidong Xu, Xia Du, Jiayao Li, Zhiyi Zhang, Xiaoyuan Ma, Dan Luo, Mingzhong Xiao, Quancai Sun
Summary: This study investigated the molecular mechanisms of SiNiSan in treating liver damage using mice and cell culture models. The results showed that SiNiSan alleviated liver injury and promoted liver cell regeneration. This study provides a theoretical basis for the clinical treatment of liver-related diseases with SiNiSan.
Review
Biochemistry & Molecular Biology
Xinbing Yang, Yajing Du, Lulu Luo, Xinru Xu, Shizheng Xiong, Xueni Yang, Li Guo, Tingming Liang
Summary: Dysregulated expression of specific non-coding RNAs (ncRNAs) has been strongly linked to tumorigenesis, cancer progression, and therapeutic resistance. Recent evidence suggests that ncRNAs can interact with the Wnt/beta-catenin signaling pathway, influencing the expression of Wnt target genes in cancer cells. This review aims to unravel the complex associations between ncRNAs and the Wnt/beta-catenin signaling pathway and explore their potential implications for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Daniel Baumhoer, Ruth Berthold, Ilka Isfort, Lorena Heinst, Baptiste Ameline, Inga Grunewald, Florian M. Thieringer, Claudia Rudack, Eva Wardelmann, Volker Vieth, Jan Sperveslage, Marcel Trautmann, Wolfgang Hartmann
Summary: The study reveals that osteomas are genetically-driven neoplasms caused by mutations in the CTNNB1 gene and associated with aberrant activation of WNT/β-catenin signaling. It provides a better understanding of the molecular pathogenesis underlying osteoma development and establishes a diagnostic molecular marker for morphologically challenging cases.
Article
Hematology
Georg Hess, Andreas Huettmann, Mathias Witzens-Harig, Martin H. Dreyling, Ulrich Keller, Reinhard Marks, Thomas Ernst, Christiane Pott, Andreas Viardot, Fabian Frontzek, Marcel Trautmann, Christian Ruckes, Oliver Deuster, Andreas Rosenwald, Matthias Theobald, Georg Lenz
Summary: The combination of pixantrone with obinutuzumab showed clinical activity in patients with relapsed or refractory DLBCL, with an overall response rate of 35.3%. Median progression-free survival was 2.8 months and overall survival was 8 months. Patients with non-GCB phenotype had a superior outcome.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Oncology
Charlotte Ruether, Christian Wuensch, Gerrit Randau, Ulf Michgehl, Marcel Trautmann, Wolfgang Hartmann, Sarah Sandmann, Martin Dugas, Tasneem Khanam, Birgit Burkhardt
Summary: Low incidence and molecular heterogeneity of pediatric T-cell lymphoblastic lymphoma (T-LBL) require an international, large-scale effort to identify novel clinical biomarkers. This study developed an optimized gene panel with 84 candidate genes, involving key genes in signaling pathways and cell functions. Exploratory analysis on mutation-level suggested potential mutation associations with relapse. Our approach promotes comprehensive and clinically relevant mutational profiling of pediatric T-LBL.
GENES CHROMOSOMES & CANCER
(2022)
Article
Oncology
Magdalene Cyra, Miriam Schulte, Ruth Berthold, Lorena Heinst, Esther-Pia Jansen, Inga Gruenewald, Sandra Elges, Olle Larsson, Christoph Schliemann, Konrad Steinestel, Susanne Hafner, Thomas Simmet, Eva Wardelmann, Sareetha Kailayangiri, Claudia Rossig, Ilka Isfort, Marcel Trautmann, Wolfgang Hartmann
Summary: In this study, we found that CREB is phosphorylated and activated in SySa, accompanied by the expression of downstream targets. Human mesenchymal stem cells engineered to express SS18-SSX promote CREB expression and phosphorylation. Conversely, RNAi-mediated knockdown of SS18-SSX impairs CREB phosphorylation in SySa cells. Inhibition of CREB activity reduces downstream target expression, accompanied by suppression of SySa cell proliferation and induction of apoptosis in vitro and in vivo.
Article
Oncology
Ruth Berthold, Ilka Isfort, Cihan Erkut, Lorena Heinst, Inga Gruenewald, Eva Wardelmann, Thomas Kindler, Pierre Aman, Thomas G. P. Gruenewald, Florencia Cidre-Aranaz, Marcel Trautmann, Stefan Froehling, Claudia Scholl, Wolfgang Hartmann
Summary: Myxoid liposarcoma (MLS), a common subtype of liposarcoma, is characterized by a recurrent chromosomal translocation generating a chimeric FUS-DDIT3 fusion gene. The study reveals that FUS-DDIT3-driven IGF-IR/PI3K/AKT signaling promotes stability and nuclear accumulation of YAP1 via deregulation of the Hippo pathway, and demonstrates substantial cooperative effects of YAP1 and FUS-DDIT3 in the pathogenesis of MLS.
Article
Pathology
Abbas Agaimy, Martina Baneckova, John De Almeida, Brendan C. Dickson, Arno Dimmler, Wolfgang Hartmann, Marick Lae, Jessica Pablik, Christoph Schubart, Alena Skalova, Robert Stoehr, Marcel Trautmann, Eva Wardelmann, Michel Wassef, Ilan Weinreb
Summary: In the past two decades, the nosology of poorly differentiated sinonasal tract malignancies has undergone significant changes, with the discovery of new molecularly defined entities and the identification of genetic driver mutations. A novel sinonasal sarcoma characterized by undifferentiated spindle/round cell morphology and recurrent EWSR1::COLCA2 fusions is described in this study.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Fabian Frontzek, Annette M. M. Staiger, Ramona Wullenkord, Michael Grau, Myroslav Zapukhlyak, Katrin S. S. Kurz, Heike Horn, Tabea Erdmann, Falko Fend, Julia Richter, Wolfram Klapper, Peter Lenz, Stephan Hailfinger, Anna Tasidou, Marcel Trautmann, Wolfgang Hartmann, Andreas Rosenwald, Leticia Quintanilla-Martinez, German Ott, Ioannis Anagnostopoulos, Georg Lenz
Summary: EBV associated DLBCL is a rare and aggressive B-cell lymphoma subtype with adverse clinical outcome. The precise role of EBV in lymphomagenesis and specific molecular characteristics of these lymphomas remain elusive. This study provides a comprehensive molecular analysis of primary EBV+ DLBCLs, revealing recurrent mutations activating the JAK-STAT and NOTCH pathways, frequent amplifications of 9p24.1, and implications for targeting these aberrations in preclinical and clinical studies.
Article
Oncology
Ilka Isfort, Ruth Berthold, Lorena Heinst, Eva Wardelmann, Olle Larsson, Marcel Trautmann, Wolfgang Hartmann
Summary: Synovial sarcoma, a rare soft tissue tumor, is driven by the fusion protein SS18-SSX that dysregulates gene transcription and affects the activities of YAP1/TAZ and β-catenin. This study reveals a mutual dependence between YAP1/TAZ and β-catenin activation in synovial sarcoma, and the interaction with the SS18-SSX fusion protein within the BAF complex.
MOLECULAR CANCER RESEARCH
(2023)
Article
Pathology
Salome Glauser, Baptiste Ameline, Vanghelita Andrei, Dorothee Harder, Chantal Pauli, Marcel Trautmann, Wolfgang Hartmann, Daniel Baumhoer
Summary: Mesenchymal chondrosarcoma (MCS) is a rare and highly aggressive tumor defined by a fusion transcript involving HEY1 and NCOA2. Diagnosis of MCS can be challenging, especially in core needle biopsies. This study evaluated the diagnostic value of NKX3.1 immunohistochemistry and methylome profiling in 45 well-characterized MCS cases. Methylome profiling revealed a distinct cluster for MCS and showed potential to aid in diagnosis, even when analyzing separate components. NKX3.1 immunohistochemistry had low sensitivity but high specificity. Overall, methylome profiling is a reliable tool for supporting MCS diagnosis.
Meeting Abstract
Oncology
Salome Glauser, Baptiste Ameline, Vanghelita Andrei, Dorothee Harder, Chantal Pauli, Marcel Trautmann, Wolfgang Hartmann, Daniel Baumhoer
Article
Pathology
Eva Wardelmann, Anna Kuntze, Marcel Trautmann, Wolfgang Hartmann
Summary: Gastrointestinal stromal tumors are the most common mesenchymal tumors in the abdomen and accurate identification plays a vital role in prognosis and therapy. Reference pathology can be used to support correct diagnosis.
Meeting Abstract
Oncology
Ruth Berthold, Ilka Isfort, Cihan Erkut, Lorena Heinst, Inga Gruenewald, Eva Wardelmann, Thomas Kindler, Pierre Aman, G. P. Gruenewald, Florencia Cidre-Aranaz, Marcel Trautmann, Stefan Froehling, Claudia Scholl, Wolfgang Hartmann
CLINICAL CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Ruth Berthold, Ilka Isfort, Cihan Erkut, Lorena Heinst, Inga Gruenewald, Eva Wardelmann, Thomas Kindler, Pierre Aman, Thomas G. P. Gruenewald, Florencia Cidre-Aranaz, Marcel Trautmann, Stefan Froehling, Claudia Scholl, Wolfgang Hartmann
CLINICAL CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Lorena Heinst, Ruth Berthold, Ilka Isfort, Svenja Wosnig, Thomas Kindler, Pierre Aman, Eva Wardelmann, Claudia Scholl, Stefan Frohling, Wolfgang Hartmann, Marcel Trautmann
CLINICAL CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Ilka Isfort, Ruth Berthold, Lorena Heinst, Eva Wardelmann, Marcel Trautmann, Wolfgang Hartmann
CLINICAL CANCER RESEARCH
(2022)