Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

(2020) Peter Richardson et al.   LANCET

Coronavirus puts drug repurposing on the fast track

(2020) Charlotte Harrison   NATURE BIOTECHNOLOGY

The COVID‐19 epidemic

(2020) Thirumalaisamy P. Velavan et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

Favipiravir: Pharmacokinetics and Concerns About Clinical Trials for 2019‐nCoV Infection

(2020) Yin‐Xiao Du et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study

(2020) Junmei Wang   Journal of Chemical Information and Modeling

Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets

(2020) Su-Jin Park et al.   mBio

Remdesivir in covid-19

(2020) Robin E Ferner et al.   BMJ-British Medical Journal

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

(2020) Richard T. Eastman et al.   ACS Central Science

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

The genetic sequence, origin, and diagnosis of SARS-CoV-2

(2020) Huihui Wang et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study

(2020) Abdo A. Elfiky   LIFE SCIENCES

Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses

(2020) E. Susan Amirian et al.   One Health

Breaking the paradigm: Dr. Insight empowers signature-free, enhanced drug repurposing

(2019) Jinyan Chan et al.   BIOINFORMATICS

Molecular Mechanisms Related to Hormone Inhibition Resistance in Prostate Cancer

(2019) Veronica Mollica et al.   Cells

Drug repositioning for dengue haemorrhagic fever by integrating multiple omics analyses

(2019) Takayuki Amemiya et al.   Scientific Reports

Drug repositioning in head and neck squamous cell carcinoma: An integrated pathway analysis based on connectivity map and differential gene expression

(2019) Gan-guan Wei et al.   PATHOLOGY RESEARCH AND PRACTICE

Organogold drug Auranofin exhibits anti-melanogenic activity in B16F10 and MNT-1 melanoma cells

(2019) Shilpi Goenka et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Artificial intelligence facilitates drug design in the big data era

(2019) Liangliang Wang et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Cushing’s Disease

(2019) Nishioka et al.   Journal of Clinical Medicine

Predicting associations among drugs, targets and diseases by tensor decomposition for drug repositioning

(2019) Ran Wang et al.   BMC BIOINFORMATICS

Novel Systemic Therapies for Advanced Gastric Cancer

(2018) Hong Jun Kim et al.   Journal of Gastric Cancer

Review of Drug Repositioning Approaches and Resources

(2018) Hanqing Xue et al.   International Journal of Biological Sciences

Editorial: Drug Repositioning: Current Advances and Future Perspectives

(2018) Yuhei Nishimura et al.   Frontiers in Pharmacology

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Profile of Mutations in the Reverse Transcriptase and Overlapping Surface Genes of Hepatitis B Virus (HBV) in Treatment-Naïve Indonesian HBV Carriers

(2017) Laura Navika Yamani et al.   JAPANESE JOURNAL OF INFECTIOUS DISEASES

Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity

(2017) Yanfen Niu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Deep-Learning-Based Drug–Target Interaction Prediction

(2017) Ming Wen et al.   JOURNAL OF PROTEOME RESEARCH

Everolimus long-term use in patients with tuberous sclerosis complex: Four-year update of the EXIST-2 study

(2017) John J. Bissler et al.   PLoS One

Drug combination therapy increases successful drug repositioning

(2016) Wei Sun et al.   DRUG DISCOVERY TODAY

Hydroxychloroquine augments early virological response to pegylated interferon plus ribavirin in genotype-4 chronic hepatitis C patients

(2016) Gouda Kamel Helal et al.   JOURNAL OF MEDICAL VIROLOGY

MeSHDD: Literature-based drug-drug similarity for drug repositioning

(2016) Adam S Brown et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Repurposing of approved cardiovascular drugs

(2016) Junichi Ishida et al.   Journal of Translational Medicine

Drug Repositioning: An Approach for Drug Discovery

(2016) Parin Vora et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

DrugCentral: online drug compendium

(2016) Oleg Ursu et al.   NUCLEIC ACIDS RESEARCH

Novel therapeutics for coronary artery disease from genome-wide association study data

(2015) Mani P Grover et al.   BMC Medical Genomics

Academic drug discovery: current status and prospects

(2015) Jeremy R Everett   Expert Opinion on Drug Discovery

Deep Neural Nets as a Method for Quantitative Structure–Activity Relationships

(2015) Junshui Ma et al.   Journal of Chemical Information and Modeling

Drug repurposing in oncology—patient and health systems opportunities

(2015) Francesco Bertolini et al.   Nature Reviews Clinical Oncology

Drug repurposing and the prior art patents of competitors

(2014) Christian Sternitzke   DRUG DISCOVERY TODAY

Recent Advances in Drug Repositioning for the Discovery of New Anticancer Drugs

(2014) Joong Sup Shim et al.   International Journal of Biological Sciences

Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks

(2014) Stephen M Strittmatter   NATURE MEDICINE

2013 FDA drug approvals

(2014) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

How Thalidomide Works Against Cancer

(2014) A. K. Stewart   SCIENCE

A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia

(2013) Noa Tejman-Yarden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines

(2013) Guangxu Jin et al.   DRUG DISCOVERY TODAY

Challenges and opportunities of drug repositioning

(2013) Natalia Novac   TRENDS IN PHARMACOLOGICAL SCIENCES

Drug Repositioning: A Machine-Learning Approach through Data Integration

(2013) Francesco Napolitano et al.   Journal of Cheminformatics

HIV-1 Antiretroviral Drug Therapy

(2013) E. J. Arts et al.   Cold Spring Harbor Perspectives in Medicine

Molecular Docking: A Powerful Approach for Structure-Based Drug Discovery

(2012) Xuan-Yu Meng et al.   Current Computer-Aided Drug Design

Applications of Connectivity Map in drug discovery and development

(2012) Xiaoyan A. Qu et al.   DRUG DISCOVERY TODAY

Predicting New Indications for Approved Drugs Using a Proteochemometric Method

(2012) Sivanesan Dakshanamurthy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis

(2012) Steven B. Smith et al.   PLoS One

Drug Repurposing and the Medicinal Chemist

(2012) Jeffrey Aubé   ACS Medicinal Chemistry Letters

Duloxetine in the management of chronic musculoskeletal pain

(2012) Howard Smith et al.   Therapeutics and Clinical Risk Management

Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension

(2011) Mark G. Lewis et al.   AIDS

Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases

(2011) K. Xu et al.   BRIEFINGS IN BIOINFORMATICS

Drug repositioning for orphan diseases

(2011) D. Sardana et al.   BRIEFINGS IN BIOINFORMATICS

Literature mining, ontologies and information visualization for drug repurposing

(2011) C. Andronis et al.   BRIEFINGS IN BIOINFORMATICS

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

Accelerating access to treatments for rare diseases

(2011) Marc Dunoyer   NATURE REVIEWS DRUG DISCOVERY

Crizotinib

(2011) Alice T. Shaw et al.   NATURE REVIEWS DRUG DISCOVERY

Thalidomide: The Tragedy of Birth Defects and the Effective Treatment of Disease

(2011) James H. Kim et al.   TOXICOLOGICAL SCIENCES

Exploiting Drug Repositioning for Discovery of a Novel HIV Combination Therapy

(2010) C. L. Clouser et al.   JOURNAL OF VIROLOGY

Targeted therapy in non-small-cell lung cancer—is it becoming a reality?

(2010) Filip Janku et al.   Nature Reviews Clinical Oncology

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Hair Loss in Women

(2009) Francisco M. Camacho-Martínez   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

Medical treatments for male and female pattern hair loss

(2008) Nicole E. Rogers et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Tuberous sclerosis

(2008) Paolo Curatolo et al.   LANCET