标题
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
作者
关键词
-
出版物
Science Translational Medicine
Volume 12, Issue 557, Pages eaay8798
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2020-08-20
DOI
10.1126/scitranslmed.aay8798
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury
- (2019) Lara Planas-Paz et al. Cell Stem Cell
- Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration
- (2019) Brian J. Pepe-Mooney et al. Cell Stem Cell
- Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
- (2019) Bhagirath Chaurasia et al. SCIENCE
- Hepatocyte Stress Increases Expression of YAP and TAZ in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis
- (2019) Meghan Mooring et al. HEPATOLOGY
- Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice
- (2019) Iván M. Moya et al. SCIENCE
- Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis
- (2019) Andrew J. Haak et al. Science Translational Medicine
- Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study
- (2018) Rozenn N. Lemaitre et al. DIABETES
- Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype
- (2018) Sandybell Anorga et al. FASEB JOURNAL
- Functions of neutral ceramidase in the Golgi apparatus
- (2018) Wataru Sakamoto et al. JOURNAL OF LIPID RESEARCH
- Precision-cut liver slices: a versatile tool to advance liver research
- (2018) Elena Palma et al. Hepatology International
- Yap/Taz Deletion in Gli+Cell-Derived Myofibroblasts Attenuates Fibrosis
- (2017) Ming Liang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells
- (2017) Jennifer Y. Chen et al. Scientific Reports
- TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts
- (2017) Satoshi Noguchi et al. Scientific Reports
- Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis
- (2016) Xiaobo Wang et al. Cell Metabolism
- Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha
- (2016) Seema S. Desai et al. HEPATOLOGY
- Hedgehog regulates yes-associated protein 1 in regenerating mouse liver
- (2016) Marzena Swiderska-Syn et al. HEPATOLOGY
- Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease
- (2016) Panu K. Luukkonen et al. JOURNAL OF HEPATOLOGY
- YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis
- (2016) S. G. Szeto et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
- (2016) Katherine Martin et al. Nature Communications
- ω-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP/TAZ degradation
- (2016) Kun Zhang et al. Scientific Reports
- The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis
- (2016) Eunjeong Seo et al. Scientific Reports
- Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation
- (2016) Steven R. Caliari et al. Scientific Reports
- Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
- (2015) Fei Liu et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma
- (2015) Heng Xiao et al. CANCER SCIENCE
- Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis
- (2015) Jonathan Y. Xia et al. Cell Metabolism
- Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector
- (2015) J. Xu et al. CLINICAL SCIENCE
- Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
- (2015) Paul Angulo et al. GASTROENTEROLOGY
- TAZ Protein Accumulation Is Negatively Regulated by YAP Abundance in Mammalian Cells
- (2015) Megan L. Finch-Edmondson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Hippo pathway effector YAP controls mouse hepatic stellate cell activation
- (2015) Inge Mannaerts et al. JOURNAL OF HEPATOLOGY
- High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers
- (2015) Ingmar Mederacke et al. Nature Protocols
- A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions
- (2015) Thomas Bertero et al. Scientific Reports
- Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis
- (2015) Takhar Kasumov et al. PLoS One
- Targeting (cellular) lysosomal acid ceramidase by B13: Design, synthesis and evaluation of novel DMG-B13 ester prodrugs
- (2014) Aiping Bai et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer
- (2014) Masaki Mori et al. CELL
- Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma
- (2014) Su-xia Han et al. Journal of Immunology Research
- Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury
- (2013) Maryna Perepelyuk et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- The adipokine/ceramide axis: Key aspects of insulin sensitization
- (2013) Jonathan Y. Xia et al. BIOCHIMIE
- Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators
- (2013) A. Lavado et al. DEVELOPMENT
- Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease
- (2013) Cynthia A. Moylan et al. HEPATOLOGY
- An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis
- (2013) Masahiko Matsumoto et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Precision-cut liver slices: A tool to model the liver ex vivo
- (2013) Peter Olinga et al. JOURNAL OF HEPATOLOGY
- YAP and TAZ Regulate Skin Wound Healing
- (2013) Min-Jung Lee et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Inhibition of ceramidede novosynthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease
- (2013) Krzysztof Kurek et al. LIVER INTERNATIONAL
- Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
- (2013) Neil C Henderson et al. NATURE MEDICINE
- The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
- (2013) Randy Johnson et al. NATURE REVIEWS DRUG DISCOVERY
- Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes
- (2013) Peter J. Meikle et al. PLoS One
- Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
- (2013) Ingmar Mederacke et al. Nature Communications
- Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
- (2012) Fa-Xing Yu et al. CELL
- Construction of Conditional Acid Ceramidase Knockout Mice andin vivoEffects on Oocyte Development and Fertility
- (2012) Efrat Eliyahu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation
- (2011) Karin Schlegelmilch et al. CELL
- Discovery and Evaluation of Inhibitors of Human Ceramidase
- (2011) J. M. Draper et al. MOLECULAR CANCER THERAPEUTICS
- Role of YAP/TAZ in mechanotransduction
- (2011) Sirio Dupont et al. NATURE
- Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver
- (2010) S. Benhamouche et al. GENES & DEVELOPMENT
- A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP
- (2010) B. Zhao et al. GENES & DEVELOPMENT
- Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
- (2010) Fei Liu et al. JOURNAL OF CELL BIOLOGY
- Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation
- (2010) Xihong Liu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility
- (2010) Changyong Li et al. JOURNAL OF HEPATOLOGY
- Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies
- (2010) Inge A M de Graaf et al. Nature Protocols
- Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition
- (2010) C Ji et al. ONCOGENE
- Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
- (2010) L. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma
- (2009) Michelle Z. Xu et al. CANCER
- Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene
- (2009) Dawang Zhou et al. CANCER CELL
- Regulation of organ size: Insights from theDrosophilaHippo signaling pathway
- (2009) Madhuri Kango-Singh et al. DEVELOPMENTAL DYNAMICS
- Coordinated induction of drug transporters and phase I and II metabolism in human liver slices
- (2008) P. Olinga et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver
- (2008) M. van de Bovenkamp et al. TOXICOLOGY IN VITRO
- Novel analogs of d-e-MAPP and B13. Part 2: Signature effects on bioactive sphingolipids
- (2007) Alicja Bielawska et al. BIOORGANIC & MEDICINAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More