Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer

TRIM37 controls cancer-specific vulnerability to PLK4 inhibition

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Patterns of Genomic Instability in Breast Cancer

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Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

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Genetic and transcriptional evolution alters cancer cell line drug response

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Efficient proximity labeling in living cells and organisms with TurboID

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The BioGRID interaction database: 2019 update

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CFI-400945 is not a selective cellular PLK4 inhibitor

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TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import

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PARP inhibitors: Synthetic lethality in the clinic

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A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

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53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

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53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

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Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

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PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

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The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

(2016) Bernard Pereira et al.   Nature Communications

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

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53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

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Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

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p53 protects against genome instability following centriole duplication failure

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Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

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Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

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Reversible centriole depletion with an inhibitor of Polo-like kinase 4

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Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

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TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein

(2014) Sanchita Bhatnagar et al.   NATURE

Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues

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Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells

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A new genome-driven integrated classification of breast cancer and its implications

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The causes and consequences of genetic heterogeneity in cancer evolution

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Large-scale gene function analysis with the PANTHER classification system

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RSeQC: quality control of RNA-seq experiments

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A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

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USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis

(2012) Ying Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Timing of centrosome separation is important for accurate chromosome segregation

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Dual pathway spindle assembly increases both the speed and the fidelity of mitosis

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