Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

Loss of CDCP1 Expression Promotes Invasiveness and Poor Prognosis in Esophageal Squamous Cell Carcinoma

(2014) Genta Sawada et al.   ANNALS OF SURGICAL ONCOLOGY

CUB-domain containing protein 1 represses the epithelial phenotype of pancreatic cancer cells

(2014) Shin Miura et al.   EXPERIMENTAL CELL RESEARCH

Oncogenic Ras/ERK Signaling Activates CDCP1 to Promote Tumor Invasion and Metastasis

(2014) Takamasa Uekita et al.   MOLECULAR CANCER RESEARCH

Phenotypic screening in cancer drug discovery — past, present and future

(2014) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

A 3D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies

(2014) D. T. Dudley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human ICAM-1 Antibody Isolated by a Function-First Approach Has Potent Macrophage-Dependent Antimyeloma Activity In Vivo

(2013) Niina Veitonmäki et al.   CANCER CELL

Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models

(2013) D. Siolas et al.   CANCER RESEARCH

Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells

(2013) Takamasa Uekita et al.   CANCER SCIENCE

Characterization of Anoikis-Resistant Cells in Mouse Colonic Epithelium

(2013) Hideyoshi KAWASAKI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Combining phenotypic and proteomic approaches to identify membrane targets in a ‘triple negative’ breast cancer cell type

(2013) Steven Rust et al.   Molecular Cancer

Antibody mediated CDCP1 degradation as mode of action for cancer targeted therapy

(2013) Gwendlyn Kollmorgen et al.   Molecular Oncology

Severe malaria is associated with parasite binding to endothelial protein C receptor

(2013) Louise Turner et al.   NATURE

Spheroid culture as a tool for creating 3D complex tissues

(2013) Eelco Fennema et al.   TRENDS IN BIOTECHNOLOGY

Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells

(2012) D. S. Spassov et al.   CANCER RESEARCH

Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma

(2012) Xiumei Zhao et al.   NEURO-ONCOLOGY

In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling

(2012) B Casar et al.   ONCOGENE

An extensive comparative study of cluster validity indices

(2012) Olatz Arbelaitz et al.   PATTERN RECOGNITION

Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis

(2011) Takamasa Uekita et al.   CANCER SCIENCE

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

A tumor-suppressing function in the epithelial adhesion protein Trask

(2011) D S Spassov et al.   ONCOGENE

Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells

(2011) B Casar et al.   ONCOGENE

Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research

(2010) Jeanette Bierwolf et al.   BIOTECHNOLOGY AND BIOENGINEERING

Proteolysis-induced N-terminal Ectodomain Shedding of the Integral Membrane Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Is Accompanied by Tyrosine Phosphorylation of Its C-terminal Domain and Recruitment of Src and PKCδ

(2010) Yaowu He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Review of Three-Dimensional In Vitro Tissue Models for Drug Discovery and Transport Studies

(2010) Nelita T. Elliott et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

(2010) Beate Neumann et al.   NATURE

Variable selection using random forests

(2010) Robin Genuer et al.   PATTERN RECOGNITION LETTERS

The Transmembrane src Substrate Trask Is an Epithelial Protein that Signals during Anchorage Deprivation

(2009) Danislav S. Spassov et al.   AMERICAN JOURNAL OF PATHOLOGY

A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

(2009) V. C. Daniel et al.   CANCER RESEARCH

Inhibition of Tumor Metastasis: Functional Immune Modulation of the CUB Domain Containing Protein 1

(2009) Keisuke Fukuchi et al.   MOLECULAR PHARMACEUTICS

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

(2009) Yan Feng et al.   NATURE REVIEWS DRUG DISCOVERY

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

Targeting CUB Domain-Containing Protein 1 with a Monoclonal Antibody Inhibits Metastasis in a Prostate Cancer Model

(2008) A. C. Siva et al.   CANCER RESEARCH

Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic

(2008) G. Kurosawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens

(2008) C. Lloyd et al.   PROTEIN ENGINEERING DESIGN & SELECTION