Molecular Pharmacology of NRH:Quinone Oxidoreductase 2: A Detoxifying Enzyme Acting as an Undercover Toxifying Enzyme
出版年份 2020 全文链接
标题
Molecular Pharmacology of NRH:Quinone Oxidoreductase 2: A Detoxifying Enzyme Acting as an Undercover Toxifying Enzyme
作者
关键词
-
出版物
MOLECULAR PHARMACOLOGY
Volume 98, Issue 5, Pages 620-633
出版商
American Society for Pharmacology & Experimental Therapeutics (ASPET)
发表日期
2020-09-11
DOI
10.1124/molpharm.120.000105
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death
- (2019) Li Wan et al. SCIENCE
- NAD+ cleavage activity by animal and plant TIR domains in cell death pathways
- (2019) Shane Horsefield et al. SCIENCE
- Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2)
- (2019) Buthaina Hussein et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antimalarial Properties of Dunnione Derivatives as NQO2 Substrates
- (2019) Monivan Chhour et al. MOLECULES
- Evaluation of analogues of furan-amidines as inhibitors of NQO2
- (2018) Soraya Alnabulsi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2
- (2018) Laure-Estelle Cassagnes et al. FREE RADICAL BIOLOGY AND MEDICINE
- UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
- (2018) Vyacheslav Akimov et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- NRH:quinone oxidoreductase 2 (NQO2) and glutaminase (GLS) both play a role in large extracellular vesicles (LEV) formation in preclinical LNCaP-C4-2B prostate cancer model of progressive metastasis
- (2018) Thambi Dorai et al. PROSTATE
- UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
- (2018) Vyacheslav Akimov et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Retraction: Inactivation of the Quinone Oxidoreductases NQO1 and NQO2 Strongly Elevates the Incidence and Multiplicity of Chemically Induced Skin Tumors
- (2018) Jun Shen et al. CANCER RESEARCH
- Is There Sufficient Evidence that the Melatonin Binding Site MT3 Is Quinone Reductase 2?
- (2018) Jean A. Boutin et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- S29434, a quinone reductase 2 inhibitor: main biochemical and cellular characterization
- (2018) Jean A. Boutin et al. MOLECULAR PHARMACOLOGY
- The mouse Gene Expression Database (GXD): 2019 update
- (2018) Constance M Smith et al. NUCLEIC ACIDS RESEARCH
- Cyclic Changes in Active Site Polarization and Dynamics Drive the “Ping-pong” Kinetics in NRH:Quinone Oxidoreductase 2: An Insight from QM/MM Simulations
- (2018) Clorice R. Reinhardt et al. ACS Catalysis
- Status of Artemisinin Resistance in Malaria Parasite Plasmodium falciparum from Molecular Analyses of the Kelch13 Gene in Southwestern Nigeria
- (2018) Mary Aigbiremo Oboh et al. Biomed Research International
- The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2)
- (2017) Zoe Riches et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives
- (2017) Laure-Estelle Cassagnes et al. MOLECULES
- A subcellular map of the human proteome
- (2017) Peter J. Thul et al. SCIENCE
- The target landscape of clinical kinase drugs
- (2017) Susan Klaeger et al. SCIENCE
- Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria
- (2016) Soraya Alnabulsi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection
- (2015) Elzbieta Janda et al. Autophagy
- Binding of DNA-Intercalating Agents to Oxidized and Reduced Quinone Reductase 2
- (2015) Kevin K. K. Leung et al. BIOCHEMISTRY
- Cytoprotective Effect of Afobazole and Its Main Metabolite M-11
- (2015) I. A. Kadnikov et al. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
- Quinone reductase 2 as a promising target of melatonin therapeutic actions
- (2015) Jean A Boutin EXPERT OPINION ON THERAPEUTIC TARGETS
- In cellulo monitoring of quinone reductase activity and reactive oxygen species production during the redox cycling of 1,2 and 1,4 quinones
- (2015) Laure-Estelle Cassagnes et al. FREE RADICAL BIOLOGY AND MEDICINE
- Melatonin: Physiological effects in humans
- (2015) B. Claustrat et al. NEUROCHIRURGIE
- Tissue-based map of the human proteome
- (2015) M. Uhlen et al. SCIENCE
- From French Paradox to Cancer Treatment: Anti-cancer Activities and Mechanisms of Resveratrol
- (2014) Xuan Yang et al. Anti-Cancer Agents in Medicinal Chemistry
- Quinone Reductase 2 Is an Adventitious Target of Protein Kinase CK2 Inhibitors TBBz (TBI) and DMAT
- (2014) Kevin K. K. Leung et al. BIOCHEMISTRY
- NQO2 Is a Reactive Oxygen Species Generating Off-Target for Acetaminophen
- (2014) Teemu P. Miettinen et al. MOLECULAR PHARMACEUTICS
- A draft map of the human proteome
- (2014) Min-Sik Kim et al. NATURE
- Effect of Afobazole on Activity of Quinone Reductase 2
- (2014) I. A. Kadnikov et al. PHARMACEUTICAL CHEMISTRY JOURNAL
- Biochemical and Cellular Evidence Demonstrating AKT-1 as a Binding Partner for Resveratrol Targeting Protein NQO2
- (2014) Tze-chen Hsieh et al. PLoS One
- Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2
- (2013) Sarah E. St. John et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Chloroquine Binding Reveals Flavin Redox Switch Function of Quinone Reductase 2
- (2013) Kevin K. K. Leung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Initial Quantitative Proteomic Map of 28 Mouse Tissues Using the SILAC Mouse
- (2013) Tamar Geiger et al. MOLECULAR & CELLULAR PROTEOMICS
- Integrated proteomic analysis of post-translational modifications by serial enrichment
- (2013) Philipp Mertins et al. NATURE METHODS
- Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation
- (2012) Maria S. Volkova et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The antidote effect of quinone oxidoreductase 2 inhibitor against paraquat-induced toxicityin vitroandin vivo
- (2012) Elzbieta Janda et al. BRITISH JOURNAL OF PHARMACOLOGY
- Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells
- (2012) T.-c. Hsieh et al. CARCINOGENESIS
- Dabigatran and Dabigatran Ethyl Ester: Potent Inhibitors of Ribosyldihydronicotinamide Dehydrogenase (NQO2)
- (2012) Simon Michaelis et al. JOURNAL OF MEDICINAL CHEMISTRY
- Flavin adenine dinucleotide content of quinone reductase 2: Analysis and optimization for structure–function studies
- (2011) Kevin Ka Ki Leung et al. ANALYTICAL BIOCHEMISTRY
- Mechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein Inhibition
- (2011) Marine Dufour et al. CHEMBIOCHEM
- Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3
- (2011) Véronique Leclerc et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Insights into the redox cycle of human quinone reductase 2
- (2011) Karine Reybier et al. FREE RADICAL RESEARCH
- Characterization of cofactors, substrates and inhibitor binding to flavoenzyme quinone reductase 2 by automated supramolecular nano-electrospray ionization mass spectrometry
- (2011) Mathias Antoine et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- Novel Inhibitors of NRH:Quinone Oxidoreductase 2 (NQO2): Crystal Structures, Biochemical Activity, and Intracellular Effects of Imidazoacridin-6-ones
- (2011) Mark S. Dunstan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues as Inhibitors of Quinone Reductase 2
- (2011) P. V. Narasimha Reddy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Association of NRH:Quinone Oxidoreductase 2 Gene Promoter Polymorphism With Higher Gene Expression and Increased Susceptibility to Parkinson's Disease
- (2011) W. Wang et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- In Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF- B Signaling
- (2011) K. A. Nolan et al. MOLECULAR CANCER THERAPEUTICS
- X-ray structural studies of quinone reductase 2 nanomolar range inhibitors
- (2011) Scott D. Pegan et al. PROTEIN SCIENCE
- Screening Natural Products for Inhibitors of Quinone Reductase-2 Using Ultrafiltration LC−MS
- (2010) Yongsoo Choi et al. ANALYTICAL CHEMISTRY
- Flavin Redox Switching of Protein Functions
- (2010) Donald F. Becker et al. ANTIOXIDANTS & REDOX SIGNALING
- Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer
- (2010) Bin Sun et al. BIOORGANIC & MEDICINAL CHEMISTRY
- In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)
- (2010) Karen A. Nolan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2
- (2010) K.A. Nolan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Inactivation of the Quinone Oxidoreductases NQO1 and NQO2 Strongly Elevates the Incidence and Multiplicity of Chemically Induced Skin Tumors
- (2010) J. Shen et al. CANCER RESEARCH
- Old and new inhibitors of quinone reductase 2
- (2010) Gilles Ferry et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Potential Chemopreventive Agents Based on the Structure of the Lead Compound 2-Bromo-1-hydroxyphenazine, Isolated fromStreptomycesSpecies, Strain CNS284
- (2010) Martin Conda-Sheridan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway
- (2010) A. A. Khutornenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cooperation of NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferases reduces menadione cytotoxicity in HEK293 cells
- (2009) Takahito Nishiyama et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2
- (2009) Karen A. Nolan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- The Biochemistry of Drug Metabolism - An Introduction
- (2009) Bernard Testa et al. CHEMISTRY & BIODIVERSITY
- The Biochemistry of Drug Metabolism - An Introduction
- (2009) Stefanie D. Krämer et al. CHEMISTRY & BIODIVERSITY
- Functional polymorphisms, altered gene expression and genetic association link NRH:quinone oxidoreductase 2 to breast cancer with wild-type p53
- (2009) K.-D. Yu et al. HUMAN MOLECULAR GENETICS
- Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory Activities
- (2009) Arup Maiti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Quaternary structure changes in a second Per-Arnt-Sim domain mediate intramolecular redox signal relay in the NifL regulatory protein
- (2009) Peter Slavny et al. MOLECULAR MICROBIOLOGY
- The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)
- (2009) Jonathan A Winger et al. BMC STRUCTURAL BIOLOGY
- Interactions of DB75, a Novel Antimalarial Agent, with Other Antimalarial Drugs In Vitro
- (2008) A. E. Purfield et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2
- (2008) Barbara Calamini et al. BIOCHEMICAL JOURNAL
- Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3
- (2008) Mohamed Ettaoussi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- The Biochemistry of Drug Metabolism - An Introduction
- (2008) Bernard Testa et al. CHEMISTRY & BIODIVERSITY
- The Biochemistry of Drug Metabolism - An Introduction
- (2008) Stefanie D. Krämer et al. CHEMISTRY & BIODIVERSITY
- Quinone Reductase 2 Is a Catechol Quinone Reductase
- (2008) Yue Fu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MT3/QR2 melatonin binding site does not use melatonin as a substrate or a co-substrate
- (2008) Jean A. Boutin et al. JOURNAL OF PINEAL RESEARCH
- SALMON: Solvent Accessibility, Ligand binding, and Mapping of ligand Orientation by NMR Spectroscopy
- (2007) Christian Ludwig et al. JOURNAL OF MEDICINAL CHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search