Chloroquine Binding Reveals Flavin Redox Switch Function of Quinone Reductase 2

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

New insights into mechanisms of therapeutic effects of antimalarial agents in SLE

(2012) Daniel J. Wallace et al.   Nature Reviews Rheumatology

Flavin adenine dinucleotide content of quinone reductase 2: Analysis and optimization for structure–function studies

(2011) Kevin Ka Ki Leung et al.   ANALYTICAL BIOCHEMISTRY

Insights into the redox cycle of human quinone reductase 2

(2011) Karine Reybier et al.   FREE RADICAL RESEARCH

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

(2011) E. L. Kim et al.   NEURO-ONCOLOGY

Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response

(2011) Y. He et al.   Science Signaling

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Flavin Redox Switching of Protein Functions

(2010) Donald F. Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway

(2010) A. A. Khutornenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Flavin Reduction and Oxidation in the Redox-Sensing Quinone Reductase Lot6p fromSaccharomyces cerevisiae

(2009) Sonja Sollner et al.   BIOCHEMISTRY

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

(2009) V. Raja Solomon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New roles of flavoproteins in molecular cell biology: An unexpected role for quinone reductases as regulators of proteasomal degradation

(2009) Sonja Sollner et al.   FEBS Journal

Functional polymorphisms, altered gene expression and genetic association link NRH:quinone oxidoreductase 2 to breast cancer with wild-type p53

(2009) K.-D. Yu et al.   HUMAN MOLECULAR GENETICS

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)

(2009) Jonathan A Winger et al.   BMC STRUCTURAL BIOLOGY

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2

(2008) Barbara Calamini et al.   BIOCHEMICAL JOURNAL

Quinone reductase acts as a redox switch of the 20S yeast proteasome

(2008) Sonja Sollner et al.   EMBO REPORTS

Primaquine revisited six decades after its discovery

(2008) Nuno Vale et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Second-Line Salvage Treatment of AIDS-Associated Pneumocystis jirovecii Pneumonia

(2008) Thomas Benfield et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

An Unbiased Evaluation of CK2 Inhibitors by Chemoproteomics

(2008) James S. Duncan et al.   MOLECULAR & CELLULAR PROTEOMICS