Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair

Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators

(2020) Dongling Liu et al.   BIOCHEMICAL PHARMACOLOGY

Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain

(2019) Miguel A. Gama Sosa et al.   Acta Neuropathologica Communications

PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

(2019) Isabella Wimmer et al.   Frontiers in Immunology

Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage

(2019) Svetlana Lublinsky et al.   EBioMedicine

Membrane microdomains regulate NLRP10- and NLRP12-dependent signalling in A549 cells challenged with cigarette smoke extract

(2018) Dhirendra P. Singh et al.   ARCHIVES OF TOXICOLOGY

Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis

(2018) Sherif Rashad et al.   BRAIN RESEARCH

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis and Atherogenesis

(2018) Marit Westerterp et al.   CIRCULATION

Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review

(2018) Yue Lang et al.   MEDIATORS OF INFLAMMATION

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

(2018) Joseph Flores et al.   Nature Communications

A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood–brain barrier under flow

(2018) Adrien Mossu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood-Brain Barrier Cellular Responses Toward Organophosphates: Natural Compensatory Processes and Exogenous Interventions to Rescue Barrier Properties

(2018) Orly Ravid et al.   Frontiers in Cellular Neuroscience

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)

(2017) K. Kinnunen et al.   Journal of Cell Communication and Signaling

Inflammasomes link vascular disease with neuroinflammation and brain disorders

(2016) Nikolett Lénárt et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction

(2016) Yang Chen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation

(2015) Prajwal Gurung et al.   AMERICAN JOURNAL OF PATHOLOGY

Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1

(2015) Yang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dysfunction of brain pericytes in chronic neuroinflammation

(2015) Yuri Persidsky et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure

(2015) Liuji Chen et al.   NEUROBIOLOGY OF AGING

Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

(2015) Clémence Disdier et al.   Particle and Fibre Toxicology

Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells

(2015) Yoonjeong Jang et al.   TOXICOLOGY

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)

(2012) Meir Bialer et al.   EPILEPSY RESEARCH

Naturally Occurring Genetic Variants of Human Caspase-1 Differ Considerably in Structure and the Ability to Activate Interleukin-1β

(2012) Hella Luksch et al.   HUMAN MUTATION

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

(2011) Adam Chodobski et al.   Translational Stroke Research

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1

(2009) A. Woodfin et al.   BLOOD

Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure

(2009) Feng Chen et al.   HEPATOLOGY

Caveolae-mediated Internalization of Occludin and Claudin-5 during CCL2-induced Tight Junction Remodeling in Brain Endothelial Cells

(2009) Svetlana M. Stamatovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE