Emodin inhibits aggregation of amyloid‐β peptide 1–42 and improves cognitive deficits in Alzheimer's disease transgenic mice

Amyloid-β Immunotherapy for Alzheimer's Disease - Is It Now A Long Shot…?

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Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

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Serum levels and mutual correlations of amyloid β in patients with depression

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Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Biomarkers for Alzheimer's disease: current status and prospects for the future

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Antibody therapies in CNS diseases

(2017) Per-Ola Freskgård et al.   NEUROPHARMACOLOGY

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

(2017) Anna Munke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

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Synergistic Inhibitory Effect of Peptide–Organic Coassemblies on Amyloid Aggregation

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A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies

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Detection of Aβ Monomers and Oligomers: Early Diagnosis of Alzheimer's Disease

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The amyloid hypothesis of Alzheimer's disease at 25 years

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A comparative study of dietary curcumin, nanocurcumin, and other classical amyloid-binding dyes for labeling and imaging of amyloid plaques in brain tissue of 5×-familial Alzheimer’s disease mice

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X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ17–36 β-Hairpin

(2016) Adam G. Kreutzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

(2016) Johnny Habchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease

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Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)

(2015) Vânia Ortega Gutierres et al.   Evidence-based Complementary and Alternative Medicine

Effect of piperine on the bioavailability and pharmacokinetics of emodin in rats

(2015) Xin Di et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Chemical Fluorescent Probe for Detection of Aβ Oligomers

(2015) Chai Lean Teoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease

(2015) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Structure-Based Peptide Design to Modulate Amyloid Beta Aggregation and Reduce Cytotoxicity

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Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

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Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

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Chemical kinetics for drug discovery to combat protein aggregation diseases

(2014) Paolo Arosio et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer

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Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood–brain barrier divide

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Natural Compounds May Open New Routes to Treatment of Amyloid Diseases

(2013) Jan Bieschke   Neurotherapeutics

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

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Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

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Spectroscopic detection of β -sheet structure in nascent Aβ oligomers

(2011) Mingjuan Wang et al.   Journal of Biophotonics

Soluble Aβ oligomer production and toxicity

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Molecular basis for amyloid-  polymorphism

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Neuroprotective effects of emodin in rat cortical neurons against β-amyloid-induced neurotoxicity

(2010) Tao Liu et al.   BRAIN RESEARCH

Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer’s Aβ Peptide and Reduce its Cytotoxicity

(2010) Jermont Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

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Interpeptide interactions induce helix to strand structural transition in Aβ peptides

(2009) Takako Takeda et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study

(2008) O. L. Lopez et al.   NEUROLOGY