Irisin Recovers Osteoarthritic Chondrocytes In Vitro

Recombinant human irisin regulated collagen II, matrix metalloproteinase‑13 and the Wnt/β‑catenin and NF‑κB signaling pathways in interleukin‑1β‑induced human SW1353 cells

(2020) Xiaojun Li et al.   Experimental and Therapeutic Medicine

Noggin Inhibits IL-1β and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis

(2020) Szu-Yu Chien et al.   Cells

Irisin and Bone: From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects

(2019) Graziana Colaianni et al.   Cells

NF-B Signaling Pathways in Osteoarthritic Cartilage Destruction

(2019) Choi et al.   Cells

Irisin functions to inhibit malignant growth of human pancreatic cancer cells via downregulation of the PI3K/AKT signaling pathway

(2019) Deguo Zhang et al.   OncoTargets and Therapy

Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin

(2019) AlKhairi et al.   Cells

Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention

(2019) Francesca Cannata et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Redox and NF-κB signaling in osteoarthritis

(2018) Panagiotis Lepetsos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Clinically relevant hydrogel-based on hyaluronic acid and platelet rich plasma as a carrier for mesenchymal stem cells: Rheological and biological characterization

(2017) Gianluca Vadalà et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

JNK pathway in osteoarthritis: pathological and therapeutic aspects

(2017) Hong-xing Ge et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Physiology and role of irisin in glucose homeostasis

(2017) Nikolaos Perakakis et al.   Nature Reviews Endocrinology

Serum irisin and myostatin levels after 2 weeks of high-altitude climbing

(2017) Ewa Śliwicka et al.   PLoS One

Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy

(2017) Musarrat Maisha Reza et al.   Nature Communications

Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

(2016) Baosheng Guo et al.   CALCIFIED TISSUE INTERNATIONAL

Association of Irisin and CRP Levels with the Radiographic Severity of Knee Osteoarthritis

(2016) Yongtao Mao et al.   Genetic Testing and Molecular Biomarkers

Explore the variation of MMP3, JNK, p38 MAPKs, and autophagy at the early stage of osteoarthritis

(2016) Jie Shi et al.   IUBMB LIFE

Economic and Humanistic Burden of Osteoarthritis: A Systematic Review of Large Sample Studies

(2016) Feng Xie et al.   PHARMACOECONOMICS

Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways

(2016) Xiaoyong Qiao et al.   Scientific Reports

Longitudinal Change in Thigh Muscle Strength Prior to and Concurrent With Minimum Clinically Important Worsening or Improvement in Knee Function: Data From the Osteoarthritis Initiative

(2016) Anja Ruhdorfer et al.   Arthritis & Rheumatology

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Fndc5overexpression facilitated neural differentiation of mouse embryonic stem cells

(2015) Mahboobeh Forouzanfar et al.   CELL BIOLOGY INTERNATIONAL

Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

(2015) Andrea Palermo et al.   CLINICAL ENDOCRINOLOGY

Irisin, an exercise-induced myokine as a metabolic regulator: an updated narrative review

(2015) Ning Chen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

(2015) Magdalena Richter et al.   INTERNATIONAL ORTHOPAEDICS

Serum Irisin Levels Are Regulated by Acute Strenuous Exercise

(2015) Dennis Löffler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Resistance exercise induces a greater irisin response than endurance exercise

(2015) Yoshifumi Tsuchiya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Function of the chondrocyte PI-3 kinase-Akt signaling pathway is stimulus dependent

(2015) M.A. Greene et al.   OSTEOARTHRITIS AND CARTILAGE

The myokine irisin increases cortical bone mass

(2015) Graziana Colaianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Exercise Training and Circulating Irisin in Adults: A Meta-Analysis

(2015) Shanhu Qiu et al.   SPORTS MEDICINE

Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway

(2015) Fei Wu et al.   PLoS One

Irisin ERKs the Fat

(2014) J. Wu et al.   DIABETES

Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects

(2014) Stella S Daskalopoulou et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis

(2014) Haibo Song et al.   PLoS One

Irisin Enhances Osteoblast DifferentiationIn Vitro

(2014) Graziana Colaianni et al.   International Journal of Endocrinology

The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis

(2014) Johannah Sanchez-Adams et al.   Current Rheumatology Reports

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

A current review of molecular mechanisms regarding osteoarthritis and pain

(2013) Andrew S. Lee et al.   GENE

Resistance Exercise Training does not Affect Plasma Irisin Levels of Hemodialysis Patients

(2013) C. Moraes et al.   HORMONE AND METABOLIC RESEARCH

Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes

(2012) Silvia Díaz-Prado et al.   BMC MUSCULOSKELETAL DISORDERS

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Akt regulates skeletal development through GSK3, mTOR, and FoxOs

(2009) Satoshi Rokutanda et al.   DEVELOPMENTAL BIOLOGY

Akt-1 mediates survival of chondrocytes from endoplasmic reticulum-induced stress

(2009) Jeremy Price et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Low-intensity pulsed ultrasound activates the PI3K/Akt pathway and stimulates the growth of chondrocytes in 3D-cultures: a basic science study

(2008) Ryohei Takeuchi et al.   ARTHRITIS RESEARCH & THERAPY