Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Chagas disease

(2018) José A Pérez-Molina et al.   LANCET

Recent Development of Visceral Leishmaniasis Treatments: Successes, Pitfalls, and Perspectives

(2018) Fabiana Alves et al.   CLINICAL MICROBIOLOGY REVIEWS

The kinetochore–microtubule interface at a glance

(2018) Julie K. Monda et al.   JOURNAL OF CELL SCIENCE

Leishmaniasis

(2018) Sakib Burza et al.   LANCET

Challenges and recent progress in drug discovery for tropical diseases

(2018) Manu De Rycker et al.   NATURE

Human African trypanosomiasis

(2017) Philippe Büscher et al.   LANCET

A dynamic hydrophobic core orchestrates allostery in protein kinases

(2017) Jonggul Kim et al.   Science Advances

The unconventional kinetoplastid kinetochore: from discovery toward functional understanding

(2016) Bungo Akiyoshi   BIOCHEMICAL SOCIETY TRANSACTIONS

Divergent polo box domains underpin the unique kinetoplastid kinetochore

(2016) Olga O. Nerusheva et al.   Open Biology

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases

(2015) Lun Zhang et al.   Scientific Reports

Discovery of Unconventional Kinetochores in Kinetoplastids

(2014) Bungo Akiyoshi et al.   CELL

Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

(2014) Lucy Glover et al.   Nature Protocols

The Kinetochore

(2014) I. M. Cheeseman   Cold Spring Harbor Perspectives in Biology

Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen

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From On-Target to Off-Target Activity: Identification and Optimisation ofTrypanosoma bruceiGSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma bruceiDrug Discovery Lead Molecules

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Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

(2013) Mari Nishino et al.   eLife

High-Throughput Analysis of an RNAi Library Identifies Novel Kinase Targets in Trypanosoma brucei

(2011) Zachary B. Mackey et al.   Chemical Biology & Drug Design

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

(2011) Laura A. T. Cleghorn et al.   ChemMedChem

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

(2011) S. Alsford et al.   GENOME RESEARCH

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

(2009) Fabio Zuccotto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation

(2009) Alex N. Bullock et al.   STRUCTURE

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

(2007) Ruth Brenk et al.   ChemMedChem