Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

(2019) Lei Liu et al.   JOURNAL OF CELL BIOLOGY

Recognition of the amyloid precursor protein by human γ-secretase

(2019) Rui Zhou et al.   SCIENCE

Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion

(2019) Alex J. B. Kreutzberger et al.   SCIENCE

Uncovering the Binding Mode of γ -Secretase Inhibitors

(2019) Manuel Hitzenberger et al.   ACS Chemical Neuroscience

Structure and Function of the γ-Secretase Complex

(2019) Michael S. Wolfe   BIOCHEMISTRY

Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines

(2019) Pranesh Padmanabhan et al.   eLife

Simulating the γ-secretase enzyme: Recent advances and future directions

(2018) Rodrigo Aguayo-Ortiz et al.   BIOCHIMIE

Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer’s Disease

(2018) Iryna Voytyuk et al.   BIOLOGICAL PSYCHIATRY

Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement

(2018) Spencer A. Freeman et al.   CELL

Mapping molecular assemblies with fluorescence microscopy and object-based spatial statistics

(2018) Thibault Lagache et al.   Nature Communications

Steric exclusion and protein conformation determine the localization of plasma membrane transporters

(2018) Frans Bianchi et al.   Nature Communications

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function

(2018) Laura Martínez-Muñoz et al.   MOLECULAR CELL

Beta-secretase/BACE1 promotes APP endocytosis and processing in the endosomes and on cell membrane

(2018) Mingguang Wang et al.   NEUROSCIENCE LETTERS

Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2

(2018) Steven J. Tobin et al.   Scientific Reports

Structural basis of Notch recognition by human γ-secretase

(2018) Guanghui Yang et al.   NATURE

Super-resolution microscopy demystified

(2018) Lothar Schermelleh et al.   NATURE CELL BIOLOGY

Turning single-molecule localization microscopy into a quantitative bioanalytical tool

(2017) Philip R Nicovich et al.   Nature Protocols

Time-resolved molecule counting by photon statistics across the visible spectrum

(2017) K. S. Grußmayer et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

(2017) Adekunle T. Bademosi et al.   Nature Communications

PhotoGate microscopy to track single molecules in crowded environments

(2017) Vladislav Belyy et al.   Nature Communications

A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency

(2017) Arun Kumar Tharkeshwar et al.   Scientific Reports

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Inhomogeneity Based Characterization of Distribution Patterns on the Plasma Membrane

(2016) Laura Paparelli et al.   PLoS Computational Biology

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

(2015) Allen C. Chen et al.   JOURNAL OF CELL BIOLOGY

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

SR-Tesseler: a method to segment and quantify localization-based super-resolution microscopy data

(2015) Florian Levet et al.   NATURE METHODS

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway

(2015) Utpal Das et al.   NATURE NEUROSCIENCE

Glutamate-Induced AMPA Receptor Desensitization Increases Their Mobility and Modulates Short-Term Plasticity through Unbinding from Stargazin

(2015) Audrey Constals et al.   NEURON

Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1

(2015) Ljiljana Milenkovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of progress in single particle tracking: from methods to biophysical insights

(2015) Carlo Manzo et al.   REPORTS ON PROGRESS IN PHYSICS

Mapping molecules in scanning far-field fluorescence nanoscopy

(2015) Haisen Ta et al.   Nature Communications

The tetraspanin web revisited by super-resolution microscopy

(2015) Malou Zuidscherwoude et al.   Scientific Reports

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis

(2015) Jin Cui et al.   Cell Discovery

ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging

(2014) Martin Ovesný et al.   BIOINFORMATICS

Deciphering the Subunit Composition of Multimeric Proteins by Counting Photobleaching Steps

(2014) Ryan J. Arant et al.   CHEMPHYSCHEM

High-density single-particle tracking: quantifying molecule organization and dynamics at the nanoscale

(2014) Jean-Baptiste Sibarita   HISTOCHEMISTRY AND CELL BIOLOGY

The dynamic conformational landscape of  -secretase

(2014) N. Elad et al.   JOURNAL OF CELL SCIENCE

A fast growing spectrum of biological functions of γ-secretase in development and disease

(2013) Nathalie Jurisch-Yaksi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interactome Analyses of Mature γ-Secretase Complexes Reveal Distinct Molecular Environments of Presenilin (PS) Paralogs and Preferential Binding of Signal Peptide Peptidase to PS2

(2013) Amy Hye Won Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Super-Resolution Imaging Reveals That AMPA Receptors Inside Synapses Are Dynamically Organized in Nanodomains Regulated by PSD95

(2013) D. Nair et al.   JOURNAL OF NEUROSCIENCE

Real-Time Analysis and Visualization for Single-Molecule Based Super-Resolution Microscopy

(2013) Adel Kechkar et al.   PLoS One

AMPA receptor/TARP stoichiometry visualized by single-molecule subunit counting

(2013) P. Hastie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localizer: fast, accurate, open-source, and modular software package for superresolution microscopy

(2012) Peter Dedecker et al.   JOURNAL OF BIOMEDICAL OPTICS

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

Transient GPI-anchored protein homodimers are units for raft organization and function

(2012) Kenichi G N Suzuki et al.   Nature Chemical Biology

Synchronization of secretory protein traffic in populations of cells

(2012) Gaelle Boncompain et al.   NATURE METHODS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Wavelet analysis for single molecule localization microscopy

(2012) I. Izeddin et al.   OPTICS EXPRESS

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization

(2012) D. Calebiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Resting State Orai1 Diffuses as Homotetramer in the Plasma Membrane of Live Mammalian Cells

(2010) Josef Madl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stoichiometry of the KCNQ1 - KCNE1 ion channel complex

(2010) K. Nakajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

(2009) Tomoko Wakabayashi et al.   NATURE CELL BIOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Active γ-secretase is localized to detergent-resistant membranes in human brain

(2008) Ji-Yeun Hur et al.   FEBS Journal

Glu332in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity

(2008) Lucía Chávez-Gutiérrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-density mapping of single-molecule trajectories with photoactivated localization microscopy

(2008) Suliana Manley et al.   NATURE METHODS