Hsp90 interacts with Cdc37, is phosphorylated by PKA/PKC, and regulates Src phosphorylation in human sperm capacitation

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

(2018) Ting Li et al.   Journal of Hematology & Oncology

Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain

(2017) Wei Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoform-Specific Phosphorylation in Human Hsp90β Affects Interaction with Clients and the Cochaperone Cdc37

(2017) Minh T.N. Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Mechanism of Protein Kinase Recognition and Sorting by the Hsp90 Kinome-Specific Cochaperone Cdc37

(2016) Dimitra Keramisanou et al.   MOLECULAR CELL

Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites

(2015) Julia M. Eckl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Src Kinase Is the Connecting Player between Protein Kinase A (PKA) Activation and Hyperpolarization through SLO3 Potassium Channel Regulation in Mouse Sperm

(2015) Cintia Stival et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biphasic Role of Calcium in Mouse Sperm Capacitation Signaling Pathways

(2015) Felipe A. Navarrete et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Evidence for the involvement of proline-rich tyrosine kinase 2 in tyrosine phosphorylation downstream of protein kinase A activation during human sperm capacitation

(2014) M. A. Battistone et al.   MOLECULAR HUMAN REPRODUCTION

Heat Shock Protein 90 Has Roles in Intracellular Calcium Homeostasis, Protein Tyrosine Phosphorylation Regulation, and Progesterone-Responsive Sperm Function in Human Sperm

(2014) Kun Li et al.   PLoS One

The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation

(2013) Xin-an Lu et al.   BIOCHEMICAL JOURNAL

Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases

(2013) M. A. Battistone et al.   MOLECULAR HUMAN REPRODUCTION

Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src

(2013) Sevgi Irtegun et al.   PLoS One

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Kinases, phosphatases and proteases during sperm capacitation

(2012) Janetti Signorelli et al.   CELL AND TISSUE RESEARCH

cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit

(2012) Dario Krapf et al.   DEVELOPMENTAL BIOLOGY

Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans

(2012) Kun Li et al.   HUMAN REPRODUCTION

Secretory Phospholipase A2 Group IID Is Involved in Progesterone-Induced Acrosomal Exocytosis of Human Spermatozoa

(2012) K. Li et al.   JOURNAL OF ANDROLOGY

Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

(2012) Joanna Soroka et al.   MOLECULAR CELL

Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

(2012) Wanping Xu et al.   MOLECULAR CELL

Ion channels, phosphorylation and mammalian sperm capacitation

(2011) Pablo E Visconti et al.   ASIAN JOURNAL OF ANDROLOGY

Thr90phosphorylation of Hsp90α by protein kinase A regulates its chaperone machinery

(2011) Xiaofeng Wang et al.   BIOCHEMICAL JOURNAL

Inhibition of Ser/Thr Phosphatases Induces Capacitation-associated Signaling in the Presence of Src Kinase Inhibitors

(2010) Dario Krapf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEK Inhibition Potentiates the Activity of Hsp90 Inhibitor 17-AAG against Pancreatic Cancer Cells

(2010) Tao Zhang et al.   MOLECULAR PHARMACEUTICS

Participation of the Human Sperm Proteasome in the Capacitation Process and Its Regulation by Protein Kinase A and Tyrosine Kinase1

(2009) Milene Kong et al.   BIOLOGY OF REPRODUCTION

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

High Cholesterol Content and Decreased Membrane Fluidity in Human Spermatozoa Are Associated With Protein Tyrosine Phosphorylation and Functional Deficiencies

(2009) M. G. Buffone et al.   JOURNAL OF ANDROLOGY

Involvement of the PKC family in regulation of early development

(2009) Madhavi Kalive et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy

(2009) Xiaofeng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the molecular basis of sperm capacitation through kinase design: Fig. 1.

(2009) Pablo E. Visconti   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Src activation triggers capacitation and acrosome reaction but not motility in human spermatozoa

(2008) G. Varano et al.   HUMAN REPRODUCTION

Investigation of the role of SRC in capacitation-associated tyrosine phosphorylation of human spermatozoa

(2008) Lisa A. Mitchell et al.   MOLECULAR HUMAN REPRODUCTION

Changes of PKA and PDK1 in the principal piece of boar spermatozoa treated with a cell-permeable cAMP analog to induce flagellar hyperactivation

(2008) Hiroshi Harayama et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

(2008) J R Smith et al.   ONCOGENE