Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain

Y-632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activityin vitroandin vivo

(2016) Wenqian Wang et al.   CANCER SCIENCE

A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain

(2016) Eugene R. Viscusi et al.   PAIN

Pharmacological induction of the 70-kDa heat shock protein protects against brain injury

(2015) N. Kim et al.   NEUROSCIENCE

Gp120 in the pathogenesis of human immunodeficiency virus-associated pain

(2014) Su-Bo Yuan et al.   ANNALS OF NEUROLOGY

Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions

(2014) Komal Jhaveri et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers

(2014) David G. Soergel et al.   PAIN

Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets

(2013) Jeanette R. McConnell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

(2013) Xiao-Tao Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure, Function and Regulation of the Hsp90 Machinery

(2013) Johannes Buchner et al.   Biomedical Journal

Hsp70 Protein Complexes as Drug Targets

(2012) Victoria A. Assimon et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular chaperone heat shock protein 70 participates in the labile phase of the development of behavioural sensitization induced by a single morphine exposure in mice

(2012) Wang-Jun Qin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

14-Alkoxy- and 14-Acyloxypyridomorphinans: μ Agonist/δ Antagonist Opioid Analgesics with Diminished Tolerance and Dependence Side Effects

(2012) Subramaniam Ananthan et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Economic Costs of Pain in the United States

(2012) Darrell J. Gaskin et al.   JOURNAL OF PAIN

Resveratrol Engages AMPK to Attenuate ERK and mTOR Signaling in Sensory Neurons and Inhibits Incision-Induced Acute and Chronic Pain

(2012) Dipti V Tillu et al.   Molecular Pain

Involvement of PKA, CaMKII, PKC, MAPK/ERK and PI3K in the acute antidepressant-like effect of ferulic acid in the tail suspension test

(2012) Ana Lúcia Bertarello Zeni et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Biphasic Activation of Extracellular Signal-regulated Kinase in Anterior Cingulate Cortex Distinctly Regulates the Development of Pain-related Anxiety and Mechanical Hypersensitivity in Rats after Incision

(2011) Ru-Ping Dai et al.   ANESTHESIOLOGY

μ-Opioid receptors and regulators of G protein signaling (RGS) proteins: From a symposium on new concepts in mu-opioid pharmacology

(2011) John Traynor   DRUG AND ALCOHOL DEPENDENCE

Chronic Morphine Alters the Presynaptic Protein Profile: Identification of Novel Molecular Targets Using Proteomics and Network Analysis

(2011) Noura S. Abul-Husn et al.   PLoS One

Inhibiting Heat-Shock Protein 90 Reverses Sensory Hypoalgesia in Diabetic Mice

(2010) Michael J Urban et al.   ASN Neuro

Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment

(2010) Taka-aki Koshimizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Specific Regulation of Noncanonical p38α Activation by Hsp90-Cdc37 Chaperone Complex in Cardiomyocyte

(2010) Asuka Ota et al.   CIRCULATION RESEARCH

Serotonin, But Not N-Methyltryptamines, Activates the Serotonin 2A Receptor Via a  -Arrestin2/Src/Akt Signaling Complex In Vivo

(2010) C. L. Schmid et al.   JOURNAL OF NEUROSCIENCE

In Vivo Characterization of MMP-2200, a Mixed  /  Opioid Agonist, in Mice

(2010) J. J. Lowery et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics

(2010) Kirsten M. Raehal et al.   NEUROPHARMACOLOGY

Tamoxifen Enhances the Hsp90 Molecular Chaperone ATPase Activity

(2010) Rongmin Zhao et al.   PLoS One

Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes

(2009) H. Breivik et al.   ANNALS OF ONCOLOGY

Extracellular Signal-Regulated Kinase 1/2 Activation Counteracts Morphine Tolerance in the Periaqueductal Gray of the Rat

(2009) T. A. Macey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats

(2009) M.R. Hutchinson et al.   NEUROSCIENCE

Novel d-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral κ-opioid receptors,

(2008) Todd W. Vanderah et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of TRPV1 Contributes to Morphine Tolerance: Involvement of the Mitogen-Activated Protein Kinase Signaling Pathway

(2008) Y. Chen et al.   JOURNAL OF NEUROSCIENCE