Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation

Impaired autophagic and mitochondrial functions are partially restored by ERT in Gaucher and Fabry diseases

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Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy

(2019) Sijie Tan et al.   Scientific Reports

Synergistic Effect of Mitochondrial and Lysosomal Dysfunction in Parkinson’s Disease

(2019) Guerra et al.   Cells

Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

(2019) Julianna Kobolák et al.   EXPERIMENTAL CELL RESEARCH

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

(2019) Helle Bogetofte et al.   Frontiers in Cellular Neuroscience

Perturbations in RhoA signalling cause altered migration and impaired neuritogenesis in human iPSC-derived neural cells with PARK2 mutation

(2019) Helle Bogetofte et al.   NEUROBIOLOGY OF DISEASE

Current mechanistic insights into the CCCP-induced cell survival response

(2018) Mariame Selma Kane et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondria, lysosomes and dysfunction: their meaning in neurodegeneration

(2018) Matteo Audano et al.   JOURNAL OF NEUROCHEMISTRY

Parkin function in Parkinson's disease

(2018) Connor Arkinson et al.   SCIENCE

The Association between E326K of GBA and the Risk of Parkinson’s Disease

(2018) Yongpan Huang et al.   Parkinsons Disease

Parkinson disease: Lysosome storage disorder risk genes linked to PD

(2017) Charlotte Ridler   Nature Reviews Neurology

Mitophagy in neurodegeneration and aging

(2017) Elayne M. Fivenson et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of Antioxidant Supplements on the Survival and Differentiation of Stem Cells

(2017) Sara Shaban et al.   Oxidative Medicine and Cellular Longevity

Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis

(2017) Lorena Fernández-Mosquera et al.   Scientific Reports

Glucocerebrosidase Mutations in Parkinson Disease

(2017) Grace O’Regan et al.   Journal of Parkinsons Disease

Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease

(2017) Natalia Jiménez-Moreno et al.   Cells

Assessment of Autophagy in Neurons and Brain Tissue

(2017) Irene Benito-Cuesta et al.   Cells

Brain Disorders Due to Lysosomal Dysfunction

(2016) Alessandro Fraldi et al.   Annual Review of Neuroscience

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

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(2016) Daniel J Klionsky et al.   Autophagy

Mechanisms of communication between mitochondria and lysosomes

(2016) Nuno Raimundo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Loss of Mitochondrial Function Impairs Lysosomes

(2016) Julie Demers-Lamarche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

(2016) Pingping Song et al.   JOURNAL OF NEUROSCIENCE

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

(2016) Dorien A. Roosen et al.   Molecular Neurodegeneration

Mitochondrial dysfunction associated with glucocerebrosidase deficiency

(2016) Matthew E. Gegg et al.   NEUROBIOLOGY OF DISEASE

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

(2016) Hugo J.R. Fernandes et al.   Stem Cell Reports

N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data

(2016) Daniel A. Monti et al.   PLoS One

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

(2015) Ziv Gan-Or et al.   Autophagy

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

(2015) Francesc Baixauli et al.   Cell Metabolism

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

(2015) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines

(2015) Atossa Shaltouki et al.   Stem Cell Reports

Secondary biochemical and morphological consequences in lysosomal storage diseases

(2014) J. Alroy et al.   BIOCHEMISTRY-MOSCOW

Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria

(2014) Carina Hönscher et al.   DEVELOPMENTAL CELL

Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTS

(2014) Inna Bendikov-Bar et al.   Orphanet Journal of Rare Diseases

The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells

(2013) Benjamin S Padman et al.   Autophagy

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(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Pathophysiology of Parkinson's disease behavior – a view from the network

(2013) John N. Caviness   PARKINSONISM & RELATED DISORDERS

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

TiSH — a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

(2012) Kasper Engholm-Keller et al.   Journal of Proteomics

Mitochondria regulate autophagy by conserved signalling pathways

(2011) Martin Graef et al.   EMBO JOURNAL

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

(2011) Aaron M. Gusdon et al.   NEUROBIOLOGY OF DISEASE

Possible Existence of Lysosome-Like Organella within Mitochondria and Its Role in Mitochondrial Quality Control

(2011) Yuji Miyamoto et al.   PLoS One

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Genetic Analysis of Pathways to Parkinson Disease

(2010) John Hardy   NEURON

The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

(2010) Angela C. Poole et al.   PLoS One

Molecular pathogenesis of Parkinson disease: insights from genetic studies

(2009) Thomas Gasser   EXPERT REVIEWS IN MOLECULAR MEDICINE

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(2009) Anthony H.V. Schapira   NEUROLOGIC CLINICS

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY