Article
Chemistry, Multidisciplinary
Yang Liu, Linyu Long, Fanjun Zhang, Xuefeng Hu, Jieyu Zhang, Cheng Hu, Yunbing Wang, Jianguo Xu
Summary: The study introduced a GelMA microneedle platform for sustained and controlled local delivery of AAV-VEGF, which achieved homogeneous distribution and high transfection efficiency in ischemic brains. Results showed that MNs loaded with AAV-VEGF increased VEGF expression in the brain cortex and enhanced functional angiogenesis and neurogenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Il-doo Kim, John W. Cave, Sunghee Cho
Summary: Obese mice with acute stroke showed increased mortality, infarct volume, swelling, and blood-brain barrier disruption, along with elevated VEGF-A and VEGFR2 expression. Aflibercept could reduce brain edema and vascular permeability, improving stroke outcomes in obese subjects.
Article
Medicine, Research & Experimental
Yu-Hang Liu, Lorenz M. Brunner, Johannes Rebling, Maya Ben-Yehuda Greenwald, Sabine Werner, Michael Detmar, Daniel Razansky
Summary: This study used non-invasive imaging technology to observe and monitor the process of skin repair in mice, and found that overexpression of vascular endothelial growth factor A (VEGF-A) can promote vascularization in the skin, which was further validated by detailed histological staining results.
Article
Chemistry, Multidisciplinary
Prashant Jain, Chethan D. Shanthamurthy, Shani Leviatan Ben-Arye, Sharon Yehuda, Sharvani S. Nandikol, Hirekodathakallu Thulasiram, Vered Padler-Karavani, Raghavendra Kikkeri
Summary: A potential heparan sulfate (HS) ligand was discovered to target several growth factors using specific HS tetrasaccharide ligands. One tetrasaccharide ligand showed strong binding with the VEGF(165) growth factor, and in vitro experiments demonstrated the therapeutic potential of these synthetic HS ligands by inhibiting vascular endothelial cell proliferation, migration, and angiogenesis in the presence of VEGF(165) and the specific tetrasaccharides.
CHEMICAL COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Biochemistry & Molecular Biology
Mengqi Zhang, Qian Wu, Mimi Tang, Zhuohui Chen, Haiyue Wu
Summary: In this study, it was found that inhibition of miR-3613-3p can enhance the function of BMECs and reduce neuronal apoptosis under oxygen-glucose deprivation conditions. Additionally, interfering with miR-3613-3p expression in BMSCs can reduce its enrichment in exosomes and promote M2 polarization of microglia, thereby decreasing neuronal apoptosis.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Mannon Geindreau, Francois Ghiringhelli, Melanie Bruchard
Summary: VEGF plays a crucial role in tumor growth by promoting angiogenesis and modulating the immune response. Clinical approval has been given to therapies targeting VEGF for the treatment of various cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yasir Abdul, Sarah Jamil, Weiguo Li, Adviye Ergul
Summary: Diabetes exacerbates hemorrhagic transformation (HT) after stroke and worsens clinical outcomes, especially in female patients. Activation of MMP3 in hyperglycemic settings is shown to mediate HT in male rats. This study aims to test the hypotheses that cerebral microvascular MMP3 activation contributes to poor functional outcomes and increased HT after ischemic stroke, and MMP3 inhibition can improve functional outcomes in female diabetic rats.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Mechanics
Jyotsana Priyadarshani, Prasoon Awasthi, Pratyaksh Karan, Soumen Das, Suman Chakraborty
Summary: This study presents a simulation mimicking tumor angiogenesis microenvironment on-chip, aiming to establish favorable conditions for gradients of vascular endothelial growth factor. The model platform explores different responses of endothelial cells in a micro-confined fluidic environment, showing potential significance for organ-on-a-chip assays, disease modeling, and optimizing anti-angiogenic therapies.
Article
Gastroenterology & Hepatology
Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: There are currently no effective treatments for liver fibrosis, a disease that involves angiogenesis. The role of different microvessels in the liver during fibrogenesis is unclear, and it is difficult to treat liver fibrosis through vascular targeting. This study proposes a combined regulation of multiple different endothelial cell regulatory signaling pathways as a new strategy for liver fibrosis therapy.
Article
Biology
Yiting Zhang, Jianping Hu, Xiaoying Qu, Ke Hu
Summary: The circular RNA circRSU1 is upregulated in diabetic retinopathy patients and its interaction with miR-345-3p leads to increased TAZ levels, which contribute to the development of vascular dysfunction. Diabetic retinopathy is a major cause of visual impairment and blindness in adults with diabetes mellitus. Although circRNAs have been implicated in vascular progression, the exact role of circRNAs in diabetes-induced vascular complications remains largely unknown. The authors found that circRSU1 was significantly upregulated in diabetic retinopathy patients. Further experiments showed that knockdown of circRSU1 alleviated diabetes-induced retinal vascular dysfunction, including decreased levels of vascular endothelial growth factor, reduced inflammatory responses, and diminished oxidative stress. The study also revealed that circRSU1 interacts with miR-345-3p to upregulate TAZ expression, and downregulation of TAZ reversed the vascular dysfunction caused by increased circRSU1 expression under high glucose conditions. In conclusion, the overexpression of circRSU1 promotes vascular dysfunction through its interaction with miR-345-3p to increase TAZ levels in diabetic conditions. The findings suggest that circRSU1 may serve as a potential therapeutic target for treating vascular dysfunction in diabetes mellitus.
COMMUNICATIONS BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Rick H. G. J. van Lanen, Stan Melchers, Govert Hoogland, Olaf E. M. G. Schijns, Marc A. M. J. van Zandvoort, Roel H. L. Haeren, Kim Rijkers
Summary: The blood-brain barrier is dysfunctional in temporal lobe epilepsy, likely due to microvascular changes. Vascular endothelial growth factor (VEGF) plays a pivotal role in this process.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Nanoscience & Nanotechnology
Xiao-yu Dai, Li-jun Ren, Lang Yan, Ji-qian-zhu Zhang, Yi-fan Dong, Tao-lin Qing, Wen-jing Shi, Jin-feng Li, Fang-yuan Gao, Xiao-fang Zhang, Yi-jun Tian, Yu-ping Zhu, Jiang-bo Zhu, Ji-kuai Chen
Summary: This study demonstrated that MWCNTs can affect endothelial cell activity, disrupt tube formation and cell migration ability, subsequently affecting angiogenesis. Furthermore, the VEGF-Akt-eNOS axis plays a crucial role in MWCNT-induced endothelial cell injury.
Review
Biochemistry & Molecular Biology
Gladys Y-P Ko, Fei Yu, Kayla J. Bayless, Michael L. Ko
Summary: Diabetic retinopathy is a diabetic eye disease that affects both neural retina and retinal vasculature, leading to vision impairment. Chronic inflammation, apoptosis, and pathological angiogenesis play crucial roles in the pathogenesis of this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Tian-Hui An, Quan-Wei He, Yuan-Peng Xia, Sheng-Cai Chen, Suraj Baral, Ling Mao, Hui-Juan Jin, Ya-Nan Li, Meng-Die Wang, Jian-Guo Chen, Ling-Qiang Zhu, Bo Hu
MOLECULAR NEUROBIOLOGY
(2017)
Article
Neurosciences
Sheng-Cai Chen, Ming Huang, Quan-Wei He, Yan Zhang, Elvis Nana Opoku, Hang Yang, Hui-Juan Jin, Yuan-Peng Xia, Bo Hu
Article
Biochemistry & Molecular Biology
Yan Wan, Hui-Juan Jin, Yi-Yi Zhu, Zhi Fang, Ling Mao, Quanwei He, Yuan-Peng Xia, Man Li, Yanan Li, Xiaoqian Chen, Bo Hu
Article
Cell Biology
An-Qi Chen, Zhi Fang, Xiao-Lu Chen, Shuai Yang, Yi-Fan Zhou, Ling Mao, Yuan-Peng Xia, Hui-Juan Jin, Ya-Nan Li, Ming-Feng You, Xu-Xia Wang, Hao Lei, Quan-Wei He, Bo Hu
CELL DEATH & DISEASE
(2019)
Article
Oncology
Tong Liu, Xiang Wang, Wenquan Hu, Zhi Fang, Ying Jin, Xuedong Fang, Qing Robert Miao
Article
Cell Biology
Shulan Pi, Ling Mao, Jiefang Chen, Hanqing Shi, Yuxiao Liu, Xiaoqing Guo, Yuanyuan Li, Lian Zhou, Hui He, Cheng Yu, Jianyong Liu, Yiping Dang, Yuanpeng Xia, Quanwei He, Huijuan Jin, Yanan Li, Yu Hu, Yiliang Miao, Zhenyu Yue, Bo Hu
Summary: The P2RY12 receptor plays a crucial role in regulating macrophagy and VSMC-derived foam cell formation in advanced atherosclerosis, by inhibiting cholesterol efflux and blocking autophagy pathways. Inhibition of the P2RY12 receptor may be a potential therapeutic target for treating atherosclerosis.
Article
Clinical Neurology
Ling Mao, Huijuan Jin, Mengdie Wang, Yu Hu, Shengcai Chen, Quanwei He, Jiang Chang, Candong Hong, Yifan Zhou, David Wang, Xiaoping Miao, Yanan Li, Bo Hu
Review
Clinical Neurology
Zhifang Li, Mingfeng You, Chunnan Long, Rentang Bi, Haoqiang Xu, Quanwei He, Bo Hu
FRONTIERS IN NEUROLOGY
(2020)
Article
Medicine, Research & Experimental
Wenquan Hu, Zhong Liu, Valerie Salato, Paula E. North, Joyce Bischoff, Suresh N. Kumar, Zhi Fang, Sujith Rajan, M. Mahmood Hussain, Qing R. Miao
Summary: Infantile hemangioma is characterized by rapid growth and slow involution of disorganized blood vessels. NGBR was found to be highly expressed in the proliferating phase of hemangioma but decreased in the involuting phase. Knockdown of NGBR in HemSCs attenuated RAS activation and inhibited cell migration and proliferation, suggesting its role in controlling growth and differentiation of hemangioma stem cells.
Review
Cell Biology
Zhi Fang, Xiang Wang, Xiaoran Sun, Wenquan Hu, Qing R. Miao
Summary: Endothelial cells, the innermost cellular layer of vessels, play crucial roles in controlling vascular tone, immune responses, coagulation balance, and angiogenesis. Dysfunctions in endothelial cells are associated with various diseases, highlighting the importance of understanding the role of histone acetylation in regulating endothelial functions for potential epigenetic interventions in disease prevention and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Rentang Bi, Zhi Fang, Mingfeng You, Quanwei He, Bo Hu
Summary: Small glial cells play a crucial role in both tissue damage and repair processes after ICH, with the proportion of glial cell phenotypes determining the progression of brain tissue damage or repair.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li
Summary: This article reviews the regulation of NMDAR and its possible mechanisms in epilepsy, discussing the role of NMDAR in onset, development, and treatment, and providing more evidence for future studies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Zhi Fang, Xiaoran Sun, Xiang Wang, Ji Ma, Thomas Palaia, Ujala Rana, Benjamin Miao, Louis Ragolia, Wenquan Hu, Qing Robert Miao
Summary: The loss of cerebral cavernous malformation (CCM) genes leads to vascular lesions in the brain. This study reveals that genetic depletion of the NOGOB receptor (NGBR) in endothelial cells (ECs) results in CCM1/2 expression deficiency and cerebrovascular lesions. Mechanistically, NGBR is required for maintaining the expression of CCM1/2 in ECs through HBO1-mediated histone acetylation.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Materials Science, Biomaterials
Abdul K. Parchur, Zhi Fang, Jaidip M. Jagtap, Gayatri Sharma, Christopher Hansen, Shayan Shafiee, Wenquan Hu, Qing R. Miao, Amit Joshi
BIOMATERIALS SCIENCE
(2020)