DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications
出版年份 2020 全文链接
标题
DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications
作者
关键词
-
出版物
CELLULAR ONCOLOGY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-06-05
DOI
10.1007/s13402-020-00526-4
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis
- (2019) Zefang Tang et al. NUCLEIC ACIDS RESEARCH
- DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma
- (2018) Suet Kee Loo et al. PATHOLOGY RESEARCH AND PRACTICE
- A novel epigenetic modulating agent sensitizes pancreatic cells to a chemotherapy agent
- (2018) Manjusha Thakar et al. PLoS One
- Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells
- (2018) Luc Gailhouste et al. Cell Death & Disease
- Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
- (2018) Gwen Lomberk et al. Nature Communications
- DNMT1 ablation suppresses tumorigenesis by inhibiting the selfrenewal of esophageal cancer stem cells
- (2018) Ying Teng et al. Oncotarget
- Identification of potent inhibitors of DNA methyltransferase 1 (DNMT1) through a pharmacophore-based virtual screening approach
- (2017) Shagun Krishna et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- A DNA methylation map of human cancer at single base-pair resolution
- (2017) E Vidal et al. ONCOGENE
- DNMT1 is predictive of survival and associated with Ki-67 expression in R-CHOP-treated diffuse large B-cell lymphomas
- (2017) Suet Kee Loo et al. PATHOLOGY
- In silico design of the first DNA-independent mechanism-based inhibitor of mammalian DNA methyltransferase Dnmt1
- (2017) Vedran Miletić et al. PLoS One
- DNMT1 regulates human endometrial carcinoma cell proliferation
- (2017) Xinjing Wang et al. OncoTargets and Therapy
- MiR-377 reverses cancerous phenotypes of pancreatic cells via suppressing DNMT1 and demethylating tumor suppressor genes
- (2017) Masoumeh Azizi et al. Epigenomics
- Methylation of BNIP3 in pancreatic cancer inhibits the induction of mitochondrial-mediated tumor cell apoptosis
- (2017) Ye Li et al. Oncotarget
- Will a mAb-Based Immunotherapy Directed against Cancer Stem Cells Be Feasible?
- (2017) Silvia Santamaria et al. Frontiers in Immunology
- MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A
- (2016) Haizhou Yu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cancer statistics in China, 2015
- (2016) Wanqing Chen et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Interplay between menin and Dnmt1 reversibly regulates pancreatic cancer cell growth downstream of the Hedgehog signaling pathway
- (2016) Peng Cheng et al. CANCER LETTERS
- DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop
- (2016) Dipta Sengupta et al. EXPERIMENTAL CELL RESEARCH
- Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis
- (2016) Li Huang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK
- (2016) FENG-PING PAN et al. ONCOLOGY REPORTS
- TIP60 inhibits metastasis by ablating DNMT1−SNAIL2-driven epithelial-mesenchymal transition program
- (2016) Yanzhou Zhang et al. Journal of Molecular Cell Biology
- miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer
- (2016) Xiao Wang et al. Cell Death & Disease
- Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells
- (2016) Cristina Florean et al. Oncotarget
- Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia
- (2015) B. J. Wouters et al. BLOOD
- Immunomodulatory action of the DNA methyltransferase inhibitor SGI-110 in epithelial ovarian cancer cells and xenografts
- (2015) Pragya Srivastava et al. Epigenetics
- miR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNA (cytosine-5)-methyltransferase 1(DNMT1) expression
- (2015) Chengguang Sui et al. Journal of Translational Medicine
- Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma
- (2015) Richard A Moffitt et al. NATURE GENETICS
- The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
- (2015) et al. SCIENCE
- Genetic alterations of DNA methylation machinery in human diseases
- (2015) Tewfik Hamidi et al. Epigenomics
- Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation
- (2015) Jingdong Cheng et al. Nature Communications
- DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis
- (2015) Rajneesh Pathania et al. Nature Communications
- miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1
- (2015) Zhiheng Chen et al. Oncotarget
- A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor
- (2015) Odile Gayet et al. Oncotarget
- MicroRNA-148b and microRNA-152 reactivate tumor suppressor genes through suppression of DNA methyltransferase-1 gene in pancreatic cancer cell lines
- (2014) Masoumeh Azizi et al. CANCER BIOLOGY & THERAPY
- Antroquinonol D, Isolated from Antrodia camphorata, with DNA Demethylation and Anticancer Potential
- (2014) Sheng-Chao Wang et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Chloroquine Eliminates Cancer Stem Cells Through Deregulation of Jak2 and DNMT1
- (2014) Dong Soon Choi et al. STEM CELLS
- 5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies
- (2014) A O Gang et al. Blood Cancer Journal
- δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells
- (2014) Akihiko Fukagawa et al. Cancer Medicine
- Low-Dose Decitabine-Based Chemoimmunotherapy for Patients with Refractory Advanced Solid Tumors: A Phase I/II Report
- (2014) Hui Fan et al. Journal of Immunology Research
- Aberrant DNA methyltransferase expression in pancreatic ductal adenocarcinoma development and progression
- (2013) Jun Gao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Essential Role for Dnmt1 in the Prevention and Maintenance of MYC-Induced T-Cell Lymphomas
- (2013) S. L. Peters et al. MOLECULAR AND CELLULAR BIOLOGY
- MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine
- (2013) Y Xiang et al. ONCOGENE
- Synergistic Re-Activation of Epigenetically Silenced Genes by Combinatorial Inhibition of DNMTs and LSD1 in Cancer Cells
- (2013) Han Han et al. PLoS One
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- Immunomodulatory activity of SGI-110, a 5-aza-2′-deoxycytidine-containing demethylating dinucleotide
- (2012) Sandra Coral et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer
- (2012) Yi Li et al. CARCINOGENESIS
- Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma
- (2012) Jing-Jing Zhang et al. Clinical & Translational Oncology
- Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells
- (2012) Viviana Barra et al. Cell Division
- KLF4 is a Novel Candidate Tumor Suppressor Gene in Pancreatic Ductal Carcinoma
- (2011) Francesca Zammarchi et al. AMERICAN JOURNAL OF PATHOLOGY
- Regulation of mammalian DNA methyltransferases: a route to new mechanisms
- (2011) Hélène Denis et al. EMBO REPORTS
- The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
- (2011) Max Felle et al. NUCLEIC ACIDS RESEARCH
- Regulation of DNA methyltransferase 1 by interactions and modifications
- (2011) Weihua Qin et al. Nucleus
- Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia
- (2010) O. Goodyear et al. BLOOD
- Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1
- (2010) Weihua Qin et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing
- (2010) Chung-Fan Lee et al. JOURNAL OF CLINICAL INVESTIGATION
- Phenotype and Genotype of Pancreatic Cancer Cell Lines
- (2010) Emily L. Deer et al. PANCREAS
- Preclinical evaluation of the antineoplastic action of 5-aza-2'-deoxycytidine and different histone deacetylase inhibitors on human Ewing's sarcoma cells
- (2008) Annie Hurtubise et al. Cancer Cell International
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now