期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.01509
关键词
cancer stem cells; therapeutic antibodies; immunotherapy; effective cancer therapies; cancer genetics
类别
资金
- CSIC [PIE-201420E109]
- ISCIII [PN2014-A]
- FEDER from the EU [PI14/00703]
- Spanish Ministry of Economy, Industry and Competitiveness [RTC-2015-3786-1, RTC-2015-3846-1]
- FEDER from the EU
The cancer stem cell (CSC) hypothesis suggests that within a tumor, there is a small subpopulation of cells with stem cell properties responsible for tumor maintenance and metastasis generation. This hypothesis also implies that new antitumor drugs, rather than targeting the bulk of the tumor mass, would be more effective if they directly targeted the CSC subpopulation. The CSCs from several types of tumors have been identified with mAbs recognizing surface antigens in these cells; however, antigens specifically or exclusively expressed in the CSC population have not yet been identified. Thus, questioning the possibility of using therapeutic antibodies directed against the CSCs. Here, we review the possibilities of using antibodies directly targeting the CSCs as therapeutic agents in the form of naked antibodies, antibodies conjugated to nanoparticles, or antibody cocktails.
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