Article
Cell Biology
Huimin Jiang, Huimin Wei, Hang Wang, Zhaoyang Wang, Jianjun Li, Yang Ou, Xuechun Xiao, Wenhao Wang, Antao Chang, Wei Sun, Li Zhao, Shuang Yang
Summary: This study identifies a Zeb1-dependent mechanism that drives breast cancer progression by stimulating tumor-macrophage interplay, which could be a potential therapeutic target for the treatment of advanced cancers.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Huiting Xu, Runzhi Chen, Qian Shen, Dongmei Yang, Hui Peng, Jin Tong, Qiang Fu
Summary: The study demonstrated that the down-regulation of circ_0013587 contributes to acquired resistance to erlotinib in pancreatic cancer cells by mediating the miR-1227/E-cadherin pathway, suggesting circ_0013587 as a potential target to overcome erlotinib resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jenna Kitz, Cory Lefebvre, Joselia Carlos, Lori E. Lowes, Alison L. Allan
Summary: This study revealed that inducible knockdown of Zeb1 can lead to an aggressive p-EMT phenotype in prostate cancer cells, which can be mitigated by treatment with the 5-azacytidine drug. DNA methylation chip analysis also identified potential targets for identifying and targeting aggressive p-EMT prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Qing Li, Zhi-Wei Zhou, Wei Duan, Cheng-Yuan Qian, Shu-Nan Wang, Meng-Sheng Deng, Dan Zi, Jian-Min Wang, Cheng-Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover, Cheng-Xiong Xu
Summary: High APE1 expression is associated with lymph node metastasis in cervical cancer and linked to epithelial to mesenchymal transition (EMT). APE1 promotes invasion and metastasis of cervical cancer cells, while inhibiting APE1 may suppress EMT. Targeting APE1 redox function could be a novel strategy for inhibiting cervical cancer metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Huichen Zhao, Huihui Hu, Beibei Chen, Weifeng Xu, Jing Zhao, Chen Huang, Yishu Xing, Huifang Lv, Caiyun Nie, Jianzheng Wang, Yunduan He, Sai-Qi Wang, Xiao-Bing Chen
Summary: Gastric cancer ranks fifth in global cancer incidence and third in cancer mortality. E-cadherin is crucial in tumorigenesis, tumor progression, metastasis, with soluble E-cadherin playing a role in promoting invasion and metastasis in gastric cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Oncology
Lara Buecker, Ulrich Lehmann
Summary: This article summarizes the research on DNA methylation of the CDH1 gene in human breast cancer and explains the diversity of results. Proper understanding of the methodological basis is crucial for the correct interpretation of the clinical relevance of aberrant DNA methylation in cancer specimens.
Article
Multidisciplinary Sciences
Yaman Alghamian, Chadi Soukkarieh, Abdul Qader Abbady, Hossam Murad
Summary: Ovarian cancer cells undergo EMT-like changes during the development of chemoresistance, and these changes are regulated by DNA methylation. Specifically, the EMT genes CDH1 and EPCAM show increased DNA methylation and down-regulated gene expression in the cisplatin-resistant A2780cis cells, while the mesenchymal marker TWIST2 exhibits decreased DNA methylation and up-regulated gene expression. These findings contribute to a better understanding of the molecular alterations associated with chemoresistance and may provide potential therapeutic targets for improving chemotherapy sensitivity and efficacy.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Dahua Xu, Shun Ding, Meng Cao, Xiaorong Yu, Hong Wang, Dongqin Qiu, Zhengyang Xu, Xiaoman Bi, Zhonglin Mu, Kongning Li
Summary: The study reveals the dual functions of CST6 in different types of cancer, regulated by DNA methylation. CST6 expression is correlated with epithelial cell infiltration, proliferation, and plays a protective role in melanoma metastasis.
FRONTIERS IN GENETICS
(2021)
Article
Chemistry, Multidisciplinary
Miaomiao Zhang, Juan Qin, Xinyue Guo, Zongjia Li, Christian Rankl, Bailin Zhang, Jilin Tang
Summary: During tumor-associated epithelial-mesenchymal transition (EMT), the expression of the EMT marker E-cadherin is challenging to detect on cancer cell surfaces in the middle and late stages of EMT. This study investigated the changes in trace E-cadherin on the living bladder cancer T24 cell surface during EMT using force-distance curve-based atomic force microscopy. The results showed that T24 cells remain in an intermediate state and can be transformed into the mesenchymal phenotype through long-term TGF-β1 induction.
Article
Oncology
Xiaohui Yang, Fei Sun, Yueying Gao, Mengyongwei Li, Mian Liu, Yunjian Wei, Qiuling Jie, Yibing Wang, Jiaoqi Mei, Jingjing Mei, Linna Ma, Yuechuan Shi, Manling Chen, Yongsheng Li, Qi Li, Mingyao Liu, Yanlin Ma
Summary: This study reveals that the histone acetyltransferase CSRP2BP plays a crucial role in epithelial-mesenchymal transition (EMT) and metastasis of cervical cancer. The overexpression of CSRP2BP promotes cell proliferation, metastasis and resistance to cisplatin chemotherapy in cervical cancer. Mechanistically, CSRP2BP upregulates the transcription of N-cadherin by mediating histone acetylation and cooperating with the transcription factor SMAD4. This study suggests that CSRP2BP could be a prognostic marker and a potential therapeutic target for cervical cancer metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G. Doench, Lynda Bennett, Beth Levine
Summary: The study revealed previously unrecognized cooperation between Beclin 1 and E-cadherin in mediating tumor suppression in breast cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Kevin Bevant, Matthis Desoteux, Abdel Hady A. Abdel Wahab, Sabrin A. Abdel Wahab, Ayman Mohamed Metwally, Cedric Coulouarn
Summary: The study found that DNA methylation may affect the activity of TGF beta in liver cancer, promoting EMT and tumor progression. By using decitabine, the transcriptional response of HCC cells to TGF beta was impaired, inducing the expression of EMT-related transcription factors, and hypomethylation of the SNAI1 promoter associated with poor prognosis in human HCC was identified.
Article
Cell Biology
Shuangyue Liu, Liping Chu, Mingzhu Xie, Lisha Ma, Hongmei An, Wen Zhang, Jihong Deng
Summary: miR-92a-3p is upregulated in cervical cancer tissues and promotes proliferation, invasion and cell cycle transition. LATS1 acts as a tumor suppressor by inhibiting TAZ, E-cadherin, vimentin and cyclin E, and can partly reverse the effects of miR-92a-3p on cancer cell behaviors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anuka Sharma, Harmandeep Kaur, Renaissa De, Radhika Srinivasan, Arnab Pal, Shalmoli Bhattacharyya
Summary: The study revealed that cancer stem cells play a crucial role in regulating chemotherapy resistance in cervical cancer cells. Knockdown of E-cadherin induces EMT in cancer cells, imparting stem-cell like characteristics, drug resistance, and invasiveness. This research provides a novel CSC model for cervical cancer cells, which could aid in developing anti-cancer therapies.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Dapeng Sun, Chenguang Li, Fengxiang Zhang
Summary: This study aimed to investigate the effect of miR-206 on the growth and metastasis of breast cancer stem cells and clarify the precise mechanism of miR-206 on EVI-1-mediated CALR expression in driving malignant phenotype. The results showed that miR-206 mimics suppressed CALR expression, inhibited the proliferation and metastasis ability of breast cancer stem cells, and induced cellular apoptosis. Over-expression of CALR could effectively attenuate the cytotoxic effect of miR-206. Further studies demonstrated that EVI-1 could be served as a key regulator of miR206-mediated CALR expression.